[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100627963":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":27,"responsibleParty":44,"collaborators":20,"id":46,"slug":47,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":55,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":20,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":20,"overallStatus":30,"whyStopped":20,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":77},{"fullName":5,"class":6},"Universite du Littoral Cote d'Opale","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Motor learning","EXPERIMENTAL","Subjects follow a de novo motor learning protocol",[13],"Behavioral: De novo motor learning",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"BEHAVIORAL","De novo motor learning","Subjects will follow 3 sessions of de-novo motor learning (days 1, 2, 8)",[9],null,[22],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"Pierre D Morel, Dr","CONTACT","0033781692692","pierre.morel@univ-littoral.fr",[28],{"facility":29,"status":30,"city":31,"state":20,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"Eurasport","RECRUITING","Loos","59120","France","FR",{"type":36,"coordinates":37},"Point",[38,39],3.01874,50.60982,{"lat":39,"lon":38},[42],{"name":43,"role":24,"phone":25,"phoneExt":20,"email":26},"Pierre D Morel, Doctor",{"type":45,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100627963","cortical-excitability-during-de-novo-motor-learning-100627963",false,"NCT07455461","Cortical Excitability During de Novo Motor Learning","Cortical Excitability During de Novo Motor Learning in Healthy Subjects : an Exploratory Longitudinal Study","StimNovoLearn","Inclusion Criteria:\n\n* right-handed\n* healthy\n* having signed an informed consent form\n\nExclusion Criteria:\n\n* counter-indication to transcranial magnetic stimulation\n* pregnancy",true,"ALL","18 Years","35 Years",{"count":59,"type":60},40,"ESTIMATED","INTERVENTIONAL",[63],"NA","De novo motor learning is a specific learning paradigm that allows investigation of how a new motor skill is learned from scratch. Motor task learning can induce increased corticospinal excitability and reorganization of connectivity observed within the motor cortex (M1). Several studies have investigated the plasticity mechanisms underlying motor learning using simple paradigms. The results obtained have been variable, with a major trend toward increased corticospinal excitability, while other results show no increase. We expect to observe a significant increase in excitability and enhanced intracortical reorganization mechanisms within M1 in our subjects during our de novo motor learning sessions.\n\nThe primary objective of this study is to measure changes in corticospinal excitability of the motor system across 3 de novo motor learning sessions separated by different time intervals.\n\nThe secondary objectives will be: 1) to measure learning across the three practice sessions, 2) to measure changes in inhibition and facilitation across the 3 learning sessions, and 3) to measure correlations between subjects' motor performance and corticospinal and intracortical changes.",[66,67],"Motor Learning","Corticospinal Excitability","2026-03-02",{"date":70,"type":71},"2026-03-06","ACTUAL",{"date":73,"type":60},"2026-02-25",{"date":75,"type":60},"2027-06",{"name":5,"class":6},1]