[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100631297":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":26,"centralContacts":31,"locations":40,"responsibleParty":64,"collaborators":23,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":70,"acronym":71,"eligibilityCriteria":72,"healthyVolunteers":68,"sex":73,"minAge":74,"maxAge":23,"enrollmentInfo":75,"targetDuration":23,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":84,"overallStatus":43,"whyStopped":23,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Royal Brompton & Harefield NHS Foundation Trust","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Standard prednisolone taper","ACTIVE_COMPARATOR","If initial dose of prednisolone \\> 5mg\u002Fday then dose will be reduced by 2.5mg\u002Fday (round to nearest feasible dose) every 4 weeks until reaching 5mg\u002Fday. From 5mg\u002Fday to reduce by 1mg\u002Fday every 6 weeks until 3mg\u002Fday. At 3mg\u002Fday a serum cortisol will be measured after 2 weeks. If cortisol \\> 25nmol\u002FL, then continue with the Meeran prednisolone taper protocol which is reducing by 1mg every 7 days.",[13],"Drug: Standard prednisolone taper",{"label":15,"type":10,"description":16,"interventionNames":17},"Fast prednisolone taper","If initial prednisolone dose \\> 5mg\u002Fday then reduce by 2.5mg\u002Fday (round to nearest feasible dose) every 4 weeks until reaching 5mg\u002Fday. From 5mg\u002Fday to reduce by 1mg every 2 weeks until 3mg\u002Fday. At 3mg\u002Fday then measure serum cortisol after 2 weeks. If cortisol \\> 25nmol\u002FL then continue to taper by 1mg every 2 weeks. In this arm, patients will contacted over the phone every 2 weeks to provide support with the tapering regimen.",[18],"Drug: Fast prednisolone taper",[20,24],{"type":21,"name":9,"description":11,"armGroupLabels":22,"otherNames":23},"DRUG",[9],null,{"type":21,"name":15,"description":16,"armGroupLabels":25,"otherNames":23},[15],[27],{"name":28,"affiliation":29,"role":30},"Vasileios Kouranos","Interstitial Lung Disease Department, Royal Brompton Hospital","PRINCIPAL_INVESTIGATOR",[32,37],{"name":28,"role":33,"phone":34,"phoneExt":35,"email":36},"CONTACT","+44(0) 207 352 8121","84405","vasileios.kouranos@nhs.net",{"name":38,"role":33,"phone":23,"phoneExt":23,"email":39},"Jessica Raja","jessica.raja2@nhs.net",[41],{"facility":42,"status":43,"city":44,"state":23,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Royal Brompton Hospital","RECRUITING","London","SW36NP","United Kingdom","UK",{"type":49,"coordinates":50},"Point",[51,52],-0.12574,51.50853,{"lat":52,"lon":51},[55,57,58,60,62],{"name":28,"role":33,"phone":56,"phoneExt":23,"email":36},"020 7352 8121",{"name":28,"role":30,"phone":23,"phoneExt":23,"email":23},{"name":38,"role":59,"phone":23,"phoneExt":23,"email":23},"SUB_INVESTIGATOR",{"name":61,"role":59,"phone":23,"phoneExt":23,"email":23},"Elisabetta Renzoni",{"name":63,"role":59,"phone":23,"phoneExt":23,"email":23},"Athol Wells",{"type":65,"investigatorFullName":23,"investigatorTitle":23,"investigatorAffiliation":23,"oldNameTitle":23,"oldOrganization":23},"SPONSOR","100631297","corticosteroid-tapering-in-sarcoidosis-100631297",false,"NCT07498842","Corticosteroid Tapering in Sarcoidosis","SARC-Taper","Inclusion Criteria:\n\n* Confirmed sarcoidosis by: (a) Histological diagnosis and\u002For (b) Multidisciplinary Team (MDT) diagnosis\n* Prednisolone 5-10mg\u002Fday for \\> 6 months\n* Clinically stable disease for \\> 6 months (no flares or dose escalation)\n* On or off second-line agent\n* \\> 18 years old\n* Written informed consent provided\n\nExclusion Criteria:\n\n* Cardiac or neurosarcoidosis\n* Advanced pulmonary sarcoidosis defined as either: (a) composite physiological index (CPI) \\> 40 (b) pulmonary hypertension\n* Active sarcoidosis flare or dose escalation in the past 6 months\n* Known adrenal insufficiency\n* Pregnancy or breastfeeding\n* Previous or current infliximab use","ALL","18 Years",{"count":76,"type":77},100,"ESTIMATED","INTERVENTIONAL",[80],"NA","Sarcoidosis is an inflammatory condition affecting many different parts of the body but most commonly the lungs. It is not known what causes sarcoidosis. In some patients no treatment is needed but in other patients long term treatment may be required.\n\nOne of the main medications used to manage this condition is corticosteroids. This medication has been shown to be very effective at reducing inflammation in this condition and many patients often remain on it for months to years.\n\nUnfortunately, there are many negative long-term side effects of corticosteroid use. This includes an increased risk of developing diabetes, reduced bone density, weight gain, high blood pressure and low muscle mass. Currently there are no guidelines for how steroids should be weaned in patients who have stable sarcoidosis.\n\nThe investigators aim to undertake a study at the Royal Brompton Hospital which will be assessing two different steroid tapering regimens which will be allocated to participants in a randomised manner. This will be the first study to directly evaluate different steroid weaning regimens in sarcoidosis patients.\n\nThe main aim of this study is to determine how many participants can reduce their prednisolone dose to less than 50% from their baseline dose. Additionally, the investigators will be recording how many participants require an increase in dose or an additional medication whilst on the prednisolone weaning regimen. The investigators will also see the tolerability of steroid withdrawal and assess for any symptoms of steroid withdrawal. In a small subset of participants the investigators will assess for any changes in body composition and muscle strength using bioelectrical impedance analysis and isometric muscle testing.",[83],"Sarcoidosis",[85],"corticosteroid tapering","2026-03-23",{"date":88,"type":89},"2026-03-27","ACTUAL",{"date":91,"type":89},"2026-03-19",{"date":93,"type":77},"2027-10-18",{"name":5,"class":6},1]