[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100637384":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":25,"locations":31,"responsibleParty":48,"collaborators":18,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":18,"eligibilityCriteria":58,"healthyVolunteers":54,"sex":59,"minAge":60,"maxAge":18,"enrollmentInfo":61,"targetDuration":18,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":71,"overallStatus":77,"whyStopped":18,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Universiti Putra Malaysia","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention arm","EXPERIMENTAL","Participants in the intervention arm will receive a digital RE-AIM-informed autonomy-competence intervention over four months. The intervention will aim to improve medication adherence by enhancing patients' autonomy, motivation, self-management confidence, and treatment competence.",[13],"Behavioral: RE-AIM-informed autonomy-competence intervention",{"label":15,"type":16,"description":17,"interventionNames":18},"Control arm","NO_INTERVENTION","Participants in the control group will receive standard routine cardiology care, including physician consultation, medication prescription, and usual counselling, without additional digital adherence support",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"BEHAVIORAL","RE-AIM-informed autonomy-competence intervention","Participants in the intervention arm will receive a digital RE-AIM-informed autonomy-competence intervention over four months. The intervention will aim to improve medication adherence by enhancing patients' autonomy, motivation, self-management confidence, and treatment competence. It will include individualized medication planning, shared decision-making, motivational counselling, adherence goal setting, structured medication education, pill-management support, symptom-monitoring guidance, problem-solving for adherence barriers, WhatsApp reminders, monthly telephonic follow-up, and reinforcement counselling. Family involvement will be encouraged where appropriate. Intervention fidelity will be monitored using delivery checklists, supervision, and periodic review.",[9],[26],{"name":27,"role":28,"phone":29,"phoneExt":18,"email":30},"Muhammad Arshed, Ph.D.","CONTACT","00923337474464","drarshedchaudhary@gmail.com",[32],{"facility":33,"status":18,"city":34,"state":18,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Civil Hospital Karachi, Dr. Ruth K. M. Pfau Civil Hospital Karachi","Karachi","74600","Pakistan","PK",{"type":39,"coordinates":40},"Point",[41,42],67.0104,24.8608,{"lat":42,"lon":41},[45],{"name":46,"role":28,"phone":47,"phoneExt":18,"email":30},"Muhammad Arshed","03337474464",{"type":49,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"PRINCIPAL_INVESTIGATOR","Arshed Muhammad","Principal Investigator","100637384","cost-effectiveness-of-a-re-aim-informed-autonomy-competence-intervention-to-improve-medication-adherence-and-quality-of-life-among-patients-with-heart-failure-100637384",false,"NCT07580508","Cost-effectiveness of a RE-AIM-Informed Autonomy-Competence Intervention to Improve Medication Adherence and Quality of Life Among Patients With Heart Failure","Cost-effectiveness of a RE-AIM-Informed Autonomy-Competence Intervention to Improve Medication Adherence, Health-related Quality of Life, and Implementation Outcomes Among Patients With Heart Failure: a Hybrid Effectiveness-implementation Randomized Controlled Trial","Inclusion Criteria:\n\n* Age ≥18 years\n\n  * Diagnosed heart failure for at least 6 months\n  * Prescribed ≥2 heart failure medications\n  * Documented medication non-adherence\n  * Able to provide informed consent\n  * Access to a smartphone\n\nExclusion Criteria:\n\n* Severe psychiatric illness\n* Terminal illness\n* Severe cognitive impairment\n* End-stage renal disease\n* Participation in another intervention trial","ALL","18 Years",{"count":62,"type":63},870,"ESTIMATED","INTERVENTIONAL",[66],"NA","Medication non-adherence leads to recurrent admissions, worsening symptoms, poor quality of life, and increased healthcare costs in an already overburdened health system. Existing adherence interventions in Pakistan are limited, mostly educational, and rarely guided by behavioural theory, implementation science, or economic evaluation.\n\nTherefore, a culturally appropriate, RE-AIM-informed autonomy-competence intervention is needed to improve medication adherence and quality of life among heart failure patients in Pakistan, while also assessing implementation feasibility and cost-effectiveness for future scale-up.",[69,70],"Heart Failure","Chronic Heart Failure (CHF)",[72,73,74,75,76],"Chronic Heart Failure","Medication adherence","Cost-effectiveness","Randomized controlled trial","RE-AIM","NOT_YET_RECRUITING","2026-05-06",{"date":80,"type":81},"2026-05-12","ACTUAL",{"date":83,"type":63},"2026-05-15",{"date":85,"type":63},"2026-09-15",{"name":5,"class":6},1]