[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100600352":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":36,"centralContacts":37,"locations":36,"responsibleParty":41,"collaborators":36,"id":43,"slug":44,"hasResults":45,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":36,"eligibilityCriteria":49,"healthyVolunteers":45,"sex":50,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":36,"studyType":56,"phases":57,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":65,"whyStopped":36,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":36},{"fullName":5,"class":6},"Ain Shams University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Adductor canal block (ACB) + IPACK block","ACTIVE_COMPARATOR","Group A: 25 patients will receive adductor canal block under ultrasound using 20 ml bupivacaine 0.25% and IPACK block under direct visualization of ultrasound using 15 ml bupivacaine 0.25% at the start of surgery.\n\nIPACK Block which the patient will be placed in a supine position and knee will be placed in position of 90° flexion. A low-frequency ultrasound probe will be positioned in the popliteal crease, and a spinal needle will be inserted from the medial aspect of the knee from anteromedial to posterolateral direction in a plane between the popliteal artery and the femur. The tip of the needle will be placed 1-2 cm beyond the lateral edge of the artery, and 15 ml of bupivacaine 0.25% will be injected after negative aspiration.",[13],"Procedure: Adductor Canal Block (ACB) + iPACK Block",{"label":15,"type":16,"description":17,"interventionNames":18},"Adductor Canal Block (ACB) + IPACK (sham injection)","SHAM_COMPARATOR","Group B : 25 patients will receive Adductor canal block only under ultrasound guide using 20ml bupivacaine 0.25% and IPACK block under direct visualization of ultrasound using 15 ml of saline (sham injection) at the start of the surgery. The patients in Group B will receive ACB and IPACK block (sham injection) as described above.",[19],"Procedure: Adductor Canal Block (ACB) + iPACK Block (sham injection)",[21,29],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Adductor Canal Block (ACB) + iPACK Block","Adductor Canal Block (ACB) in the immediate preoperative period under a high-frequency ultrasound guidance in which the adductor canal is identified beneath the sartorius muscle and 20 ml of bupivacaine 0.25% will be injected in the canal using a 22-gaugusing a 22-gauge 100-mm short-bevelled regional block needle.\n\nIPACK Block which the patient will be placed in a supine position and knee will be placed in position of 90° flexion. A low-frequency ultrasound probe will be positioned in the popliteal crease, and a spinal needle will be inserted from the medial aspect of the knee from anteromedial to posterolateral direction in a plane between the popliteal artery and the femur. The tip of the needle will be placed 1-2 cm beyond the lateral edge of the artery, and 15 ml of bupivacaine 0.25% will be injected after negative aspiration.",[9],[27,28],"Adductor Canal Block (ACB)","IPACK block",{"type":22,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"Adductor Canal Block (ACB) + iPACK Block (sham injection)","All patients will receive Adductor Canal Block in the immediate preoperative period under a high-frequency ultrasound guidance in which the adductor canal is identified beneath the sartorius muscle and 20 ml of bupivacaine 0.25% will be injected in the canal using a 22-gauge 100-mm short-bevelled regional block needle IPACK block which the patient will be placed in a supine position and knee will be placed in position of 90° flexion. A low-frequency ultrasound probe will be positioned in the popliteal crease, and a spinal needle will be inserted from the medial aspect of the knee from anteromedial to posterolateral direction in a plane between the popliteal artery and the femur. The tip of the needle will be placed 1-2 cm beyond the lateral edge of the artery, and 15 ml of normal saline will be injected after negative aspiration.",[15],[34,35],"Adductor Canal Block","IPACK Block (sham injection)",null,[38],{"name":39,"role":40,"phone":36,"phoneExt":36,"email":36},"Rana Magdy, Master","CONTACT",{"type":42,"investigatorFullName":36,"investigatorTitle":36,"investigatorAffiliation":36,"oldNameTitle":36,"oldOrganization":36},"SPONSOR","100600352","coupling-of-ipack-block-with-adductor-canal-block-versus-adductor-canal-block-alone-on-pain-functional-recovery-and-inflammatory-response-after-knee-replacement-100600352",false,"NCT07096375","Coupling of IPACK Block With Adductor Canal Block Versus Adductor Canal Block Alone on Pain, Functional Recovery and Inflammatory Response After Knee Replacement","Competency of Coupling of IPACK Block With Adductor Canal Block Versus Adductor Canal Block Alone on Postoperative Pain, Functional Recovery and Inflammatory Response After Total Knee Replacement","Inclusion Criteria:\n\n* Patients undergoing total knee replacement.\n* ASA physical status I to III\n* Sex (males and females).\n* Age 20 - 70 years.\n\nExclusion Criteria:\n\n* Patients undergoing bilateral or revision total knee replacement.\n* ASA physical status more than III\n* Age less than 20 or older than 70\n* severe renal insufficiency ( Estimated Glomerular filtration rate eGFR \\\u003C 15 mL\u002Fmin\u002F1.73 m2 ).\n* history of arrhythmia or seizures.\n* Hypersensitivity to local anesthetics.\n* Preexisting peripheral neuropathy and prior vascular surgery on femoral vessels on operated site.\n* Infection near site of injection e.g. osteomyelitis, septic knee joint, etc.\n* Patient refusal or with difficulties in comprehending numeric pain rating scale (NRS) pain scores\n* Any contraindications for spinal anesthesia. (eg.: refusal of patients, coagulopathy, use of anticoagulants or antiplatelets...)","ALL","20 Years","70 Years",{"count":54,"type":55},50,"ESTIMATED","INTERVENTIONAL",[58],"NA","The aim of this study is to compare the Competency of coupling of IPACK Block with Adductor Canal Block versus Adductor Canal Block Alone on Postoperative Pain after total knee replacement as well as Functional Recovery and Inflammatory Response and range of motion postoperatively.",[34,61,62],"Total Knee Replacement Surgery","Functional Recovery",[28,34,64],"Inflammatory Response","NOT_YET_RECRUITING","2025-07-24",{"date":68,"type":69},"2025-07-31","ACTUAL",{"date":71,"type":55},"2025-09-20",{"date":73,"type":55},"2026-09-28",{"name":5,"class":6}]