[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100638343":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":41,"responsibleParty":56,"collaborators":58,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":64,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":26,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":96,"whyStopped":26,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"The Hospital for Sick Children","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Continuous Positive Airway Pressure (CPAP)","ACTIVE_COMPARATOR","Participants assigned to this arm will receive Continuous Positive Airway Pressure (CPAP) therapy for the treatment of obstructive sleep apnea. CPAP delivers pressurized air through a mask worn during sleep to keep the airway open. Participants will use CPAP at home each night during sleep for a three-month intervention period, with device settings optimized based on standard clinical care.",[13],"Device: Continuous Positive Airway Pressure",{"label":15,"type":16,"description":17,"interventionNames":18},"High-Flow Nasal Cannula (HFNC)","EXPERIMENTAL","Participants assigned to this arm will receive High-Flow Nasal Cannula (HFNC) therapy for the treatment of obstructive sleep apnea. HFNC delivers warmed, humidified air at high flow rates through soft nasal prongs to support airway patency during sleep. Participants will use HFNC at home each night during sleep for a three-month intervention period, with flow settings optimized based on standard clinical care.",[19],"Device: High Flow Nasal Cannula",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","High Flow Nasal Cannula","High-Flow Nasal Cannula (HFNC) therapy delivers warmed, humidified air at high flow rates through soft nasal prongs during sleep to support upper airway patency in children with obstructive sleep apnea. The therapy is used nightly at home, with flow settings optimized according to standard clinical care and overnight sleep study titration.",[15],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Continuous Positive Airway Pressure","Continuous Positive Airway Pressure (CPAP) therapy delivers pressurized air through a nasal or oronasal mask worn during sleep to maintain upper airway patency and treat obstructive sleep apnea. CPAP therapy is used nightly at home, with pressure settings optimized according to standard clinical care and overnight sleep study titration.",[9],[32],{"name":33,"affiliation":5,"role":34},"Indra Narang","PRINCIPAL_INVESTIGATOR",[36],{"name":37,"role":38,"phone":39,"phoneExt":26,"email":40},"Aditi Garg","CONTACT","(416) 813 6809","aditi.garg@sickkids.ca",[42],{"facility":5,"status":26,"city":43,"state":44,"zip":26,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Toronto","Ontario","Canada","CA",{"type":48,"coordinates":49},"Point",[50,51],-79.39864,43.70643,{"lat":51,"lon":50},[54,55],{"name":37,"role":38,"phone":39,"phoneExt":26,"email":40},{"name":33,"role":34,"phone":26,"phoneExt":26,"email":26},{"type":34,"investigatorFullName":33,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"VP, Health Equity and Inclusion",[59],{"name":60,"class":61},"Fisher and Paykel Healthcare","INDUSTRY","100638343","cpap-vs-high-flow-nasal-cannula-for-treating-sleep-apnea-in-children-100638343",false,"NCT07600333","CPAP vs High-Flow Nasal Cannula for Treating Sleep Apnea in Children","Continuous Positive Airway Pressure vs High Flow Nasal Cannula for the Treatment of OSA in Children","CHOSA","Inclusion Criteria:\n\n* Aged 2 to 18 years\n* Diagnosed with moderate to severe obstructive sleep apnea, defined as an obstructive apnea-hypopnea index (OAHI) ≥5 events\u002Fhour, confirmed by an in-laboratory polysomnography within the previous 6 months\n* Deemed to require Continuous Positive Airway Pressure (CPAP) therapy as part of usual clinical care\n* Ability of the participant and\u002For parent or legal guardian to provide informed consent (and assent when applicable)\n\nExclusion Criteria:\n\n* Predominant or pathological central sleep apnea (central apnea-hypopnea index ≥5 events\u002Fhour)\n* Chronic respiratory failure or medical conditions requiring ventilatory support with a set respiratory rate (e.g., neuromuscular disease requiring bilevel ventilation with a backup rate)\n* Hypoventilation requiring non-invasive ventilation with a set respiratory rate\n* History of pneumothorax or pneumomediastinum\n* Uncontrolled gastroesophageal reflux and\u002For recurrent vomiting\n* Uncontrolled oral secretions\n* Prior use of CPAP or High-Flow Nasal Cannula therapy for treatment of obstructive sleep apnea within the previous 12 months","ALL","2 Years","18 Years",{"count":74,"type":75},258,"ESTIMATED","INTERVENTIONAL",[78],"NA","This study is looking at two different treatments for obstructive sleep apnea (OSA) in children. OSA is a sleep condition where breathing repeatedly stops and starts during sleep, which can affect a child's health, behavior, learning, and quality of life.\n\nChildren with moderate-to-severe OSA who cannot be treated with surgery are often prescribed Continuous Positive Airway Pressure (CPAP). CPAP uses a mask worn during sleep to deliver pressurized air and keep the airway open. Although CPAP is effective, many children have difficulty using it regularly because it can feel uncomfortable or hard to tolerate.\n\nThis study compares CPAP with another treatment called High-Flow Nasal Cannula (HFNC). HFNC delivers warm, humidified air through soft nasal prongs and may be more comfortable and easier for children to use while still helping keep the airway open during sleep.\n\nChildren aged 2 to 18 years with moderate-to-severe OSA will be randomly assigned to use either CPAP or HFNC at home during sleep for 3 months. The study will measure how much each treatment is used, how well it improves sleep-related symptoms and quality of life, how comfortable it is for children, and how it affects caregivers.\n\nThe goal of this study is to find out whether HFNC is a comfortable and effective alternative to CPAP for treating obstructive sleep apnea in children.",[81],"Obstructive Sleep Apnea (OSA)",[83,84,85,86,87,88,89,90,91,92,93,94,95],"obstructive sleep apnea","pediatric obstructive sleep apnea","children","adolescents","continuous positive airway pressure","CPAP","High Flow nasal cannula","HFNC","Sleep-disordered breathing","adherence","quality of life","home sleep therapy","randomized controlled trial","NOT_YET_RECRUITING","2026-05-14",{"date":99,"type":100},"2026-05-20","ACTUAL",{"date":102,"type":75},"2026-06-01",{"date":104,"type":75},"2031-12",{"name":5,"class":6},1]