[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100606623":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":29,"centralContacts":33,"locations":39,"responsibleParty":70,"collaborators":25,"id":74,"slug":75,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":76,"sex":82,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":25,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":94,"overallStatus":100,"whyStopped":25,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":110},{"fullName":5,"class":6},"Peking University Third Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"HIIT group","EXPERIMENTAL","Home-based HIIT performed on electric resistance bikes.",[13],"Behavioral: HIIT",{"label":15,"type":6,"description":16,"interventionNames":17},"Control Group","No specific exercise intervention.",[18],"Behavioral: No specific exercise intervention.",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","HIIT","Exercise sessions were conducted as telemedically supervised, home-based HIIT performed on electric resistance bikes, with protocols individually tailored. Each HIIT session comprised 8 cycles of alternating 30-second high-intensity intervals (HIT at 80% peakVO₂) and 60-second low-intensity recovery intervals (LIT at 50% peakVO₂). Warm-up and cool-down phases were performed with the bike's resistance set to 0 watts (unloaded pedaling). The total intervention duration was 8 weeks. Received health lifestyle education based on the Prevention and Treatment Guidelines for Metabolic (Non-Alcoholic) Fatty Liver Disease (2024 Edition) and the Dietary Guidelines for Adults with Hyperlipidemia (2023 Edition).Wear smart bracelets 24\u002F7 to monitor daily activity levels, with participants prohibited from engaging in any other systematic exercise training during the intervention period.",[9],null,{"type":21,"name":16,"description":27,"armGroupLabels":28,"otherNames":25},"The control group will not receive any exercise intervention, and they will be instructed to not take any structured exercise regimens.Received health lifestyle education based on the Prevention and Treatment Guidelines for Metabolic (Non-Alcoholic) Fatty Liver Disease (2024 Edition) and the Dietary Guidelines for Adults with Hyperlipidemia (2023 Edition).Wear smart bracelets 24\u002F7 to monitor daily activity levels, with participants prohibited from engaging in any other systematic exercise training during the intervention period.",[15],[30],{"name":31,"affiliation":5,"role":32},"Yida Tang","STUDY_CHAIR",[34],{"name":35,"role":36,"phone":37,"phoneExt":25,"email":38},"Yida Tang, MD,PhD","CONTACT","010-82265996","tangyida@bjmu.edu.cn",[40,51,56,61,65],{"facility":41,"status":25,"city":42,"state":25,"zip":25,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":25},"Beijing Ditan Hospital, Capital Medical University","Beijing","China","CN",{"type":46,"coordinates":47},"Point",[48,49],116.39723,39.9075,{"lat":49,"lon":48},{"facility":52,"status":25,"city":42,"state":25,"zip":25,"country":43,"countryCode":44,"cosmosGeoPoint":53,"geoPoint":55,"contacts":25},"Beijing Friendship Hospital, Capital Medical University",{"type":46,"coordinates":54},[48,49],{"lat":49,"lon":48},{"facility":57,"status":25,"city":42,"state":25,"zip":25,"country":43,"countryCode":44,"cosmosGeoPoint":58,"geoPoint":60,"contacts":25},"Beijing Youan Hospital, Capital Medical University",{"type":46,"coordinates":59},[48,49],{"lat":49,"lon":48},{"facility":5,"status":25,"city":42,"state":25,"zip":25,"country":43,"countryCode":44,"cosmosGeoPoint":62,"geoPoint":64,"contacts":25},{"type":46,"coordinates":63},[48,49],{"lat":49,"lon":48},{"facility":66,"status":25,"city":42,"state":25,"zip":25,"country":43,"countryCode":44,"cosmosGeoPoint":67,"geoPoint":69,"contacts":25},"The Fifth Medical Center, Chinese PLA General Hospital",{"type":46,"coordinates":68},[48,49],{"lat":49,"lon":48},{"type":71,"investigatorFullName":72,"investigatorTitle":73,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"SPONSOR_INVESTIGATOR","Tang Yida","Professor, Vice President of Peking University Third Hospital; Director of Institute of Vascular Medicine, Peking University Third Hospital; Deputy Director, State Key Laboratory of Vascular Homeostasis and Remodeling;","100606623","cpet-based-hiit-for-mafld-100606623",false,"NCT07177963","CPET-based HIIT for MAFLD","Cardiopulmonary Exercise Testing-based High-intensity Interval Training For Improving MAFLD","CEPHIT","Inclusion Criteria:\n\nAdults age 35\\~65 years Nonalcoholic fatty liver diagnosed by abdominal ultrasonography\n\nIn conjunction with at least one cardiometabolic risk factor:\n\n* Overweight or Obesity: ≥ 24kg\u002Fm2，or waist circumference ≥ 90 cm in men and \\> 85 cm in women, or excessive body fat mass\n* Prediabetes or type 2 diabetes mellitus: HbA1c ≥ 5.7%, or fasting plasma glucose ≥ 6.1mmol\u002FL, or 2-h plasma glucose during OGTT ≥ 7.8mmol\u002FL\n* Plasma triglycerides ≥ 1.7 mmol\u002FL (\\>-150 mg\u002Fdl) or lipid-lowering treatment\n* HDL-cholesterol ≤ -1.0 mmol\u002FL in men and ≤ -1.3 mmol\u002FL in women or lipid-lowering treatment\n* Blood pressure ≥ 130\u002F85 mmHg or treatment for hypertension\n\nExclusion Criteria:\n\n* Contraindications for Cardiopulmonary Exercise Testing\n* The electrocardiogram (ECG) results during cardiopulmonary exercise testing (CPET) showed positive findings\n* Receiving GLP-1 receptor agonists, SGLT-2i, or taking \\>2 antihypertensive\u002Fhypoglycemic\u002Flipid-lowering\u002F antiarrhythmic drugs\n* Taking dietary supplements (e.g., fish oil products, over-the-counter diet pills, meal replacements)\n* Mental illness\n* Other liver diseases\n* Movement disorder related diseases and lower limb motor injury in the past 6 months\n* Pregnant, lactating or planning to become pregnant in the near future","ALL","35 Years","65 Years",{"count":86,"type":87},54,"ESTIMATED","INTERVENTIONAL",[90],"NA","High-intensity interval training (HIIT), as an individualized exercise training mode based on cardiopulmonary exercise testing (CPET), is characterized by high-intensity training sessions interspersed with short rest periods. The findings from recent trials suggest that in the management of metabolic dysfunction-associated fatty liver disease (MAFLD), compared with traditional aerobic exercise modes such as moderate-intensity continuous training, HIIT may achieve similar or even better effects in reducing liver fat content, increasing peak oxygen uptake, improving insulin resistance, and lowering blood pressure, despite requiring less time commitment and lower energy expenditure. However, there is currently no consensus regarding the formulation of HIIT exercise protocols.\n\nBased on the lower limits of the current mainstream HIIT intensity, sets, and interval time parameters, this study aims to assess the effectiveness, safety, and feasibility of the current exercise prescription in improving MAFLD.",[93],"Metabolic Dysfunction-Associated Fatty Liver Disease",[95,96,97,98,99],"CPET","Exercise","HITT","Peak VO2","MAFLD","NOT_YET_RECRUITING","2025-09-10",{"date":103,"type":104},"2025-09-17","ACTUAL",{"date":106,"type":87},"2025-09-08",{"date":108,"type":87},"2026-04-30",{"name":72,"class":6},5]