[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100519957":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":27,"centralContacts":32,"locations":40,"responsibleParty":64,"collaborators":66,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":72,"sex":78,"minAge":79,"maxAge":21,"enrollmentInfo":80,"targetDuration":21,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":89,"overallStatus":43,"whyStopped":21,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Assistance Publique - Hôpitaux de Paris","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Crack-cocaine Use Disorder users","EXPERIMENTAL","Observation of behaviour in ecological conditions in patients with crack-cocaine dependence",[13,14],"Behavioral: Observation of behavior and search of biomarkers with 3 blood tests.3 weeks wearing an actimeter","Biological: 3 blood tests",[16,22],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":21},"BEHAVIORAL","Observation of behavior and search of biomarkers with 3 blood tests.3 weeks wearing an actimeter","In the form of a small watch, which collects the level of motor activity throughout the day and night. Patients will be asked to indicate each moment of crack-cocaine use by pressing the button in the center of the watch. We want to know if certain uses lead to more behavioral problems (especially after periods of cessation).",[9],null,{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":21},"BIOLOGICAL","3 blood tests","We will try to identify biomarkers of BS: blood proteins, genetic markers passed on by your parents, or the expression of proteins in particular situations",[9],[28],{"name":29,"affiliation":30,"role":31},"Florence VORSPAN","Hôpital Fernand Widal","PRINCIPAL_INVESTIGATOR",[33,38],{"name":34,"role":35,"phone":36,"phoneExt":21,"email":37},"Florence Vorspan, MD, PhD","CONTACT","01 40 05 44 17","Florence.vorspan@aphp.fr",{"name":34,"role":35,"phone":39,"phoneExt":21,"email":37},"0140054417",[41,54],{"facility":42,"status":43,"city":44,"state":21,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":21},"Centre 001_Hôpital Fernand Widal","RECRUITING","Paris","75010","France","FR",{"type":49,"coordinates":50},"Point",[51,52],2.3488,48.85341,{"lat":52,"lon":51},{"facility":30,"status":43,"city":44,"state":21,"zip":55,"country":46,"countryCode":47,"cosmosGeoPoint":56,"geoPoint":58,"contacts":59},"F75010",{"type":49,"coordinates":57},[51,52],{"lat":52,"lon":51},[60],{"name":61,"role":35,"phone":62,"phoneExt":21,"email":63},"Nora Keltoumi","33 1 40 05 44 17","Nora.keltoumi@aphp.fr",{"type":65,"investigatorFullName":21,"investigatorTitle":21,"investigatorAffiliation":21,"oldNameTitle":21,"oldOrganization":21},"SPONSOR",[67],{"name":68,"class":69},"Institut National de la Santé Et de la Recherche Médicale, France","OTHER_GOV","100519957","crack-target-1-descriptive-study-of-observed-behavioral-sensitization-and-expectations-100519957",false,"NCT06050304","CRACK-TARGET 1: Descriptive Study of Observed Behavioral Sensitization and Expectations","Descriptive Study of Observed Behavioural Awareness and Patients Expectations of Treatment","CRACK-TARGET","Inclusion Criteria:\n\n* \\> 18 years\n* Have a current crack-cocaine use disorder defined as Severe Intensity Use Disorder (6 or more DSM5 criteria), AND preferential use of rapid administration route (intravenous or smoked)\n* Self-identified male or female (n=10 males, n=10 females)\n* Negative pregnancy test for females and use of effective contraception\n* Be affiliated with a social security plan (or PUMA or CSS or AME)\n* Sign an informed consent and commit to a 3-week follow-up in the study\n* Have a weight greater than 40 kg\n\nExclusion Criteria:\n\n* • Patient with a psychiatric disorder or symptoms that are not currently stabilized\n\n  * Patient who is a minor or under protective supervision (curatorship or guardianship)\n  * Patient in care at the request of a judicial authority (therapeutic injunction, classification with orientation)\n  * Pregnant or breastfeeding women\n  * Patients who do not speak French or English sufficiently\n  * Patients weighing less than 40 kg","ALL","18 Years",{"count":81,"type":82},20,"ESTIMATED","INTERVENTIONAL",[85],"NA","This research focuses on behavioral sensitization (BS) a specific behavioural disturbance in crack-cocaine addiction. The primary objective is to observe whether BS can be demonstrated in an ecological setting in crack dependent users by continuous actimetry for 3 weeks.\n\nIt is planned to include 20 persons with a current crack-cocaine addiction with a preferential use of rapid administration route (intravenous or smoke), in a care institution: Fernand Widal Hospital.\n\nIn the proposed research, the investigators will assess the movements of crack-cocaine dependent users in relation to consumption. They will have to wear continuously for 3 weeks an actimeter. They will also have 3 blood tests trying to identify biomarkers of BS.",[88],"Cocaine Use Disorder",[90,91],"Crack-cocaine","Behavioral Sensitization","2026-01-13",{"date":94,"type":95},"2026-01-15","ACTUAL",{"date":97,"type":95},"2025-03-04",{"date":99,"type":82},"2026-03-04",{"name":5,"class":6},2]