[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100616779":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":11,"centralContacts":11,"locations":11,"responsibleParty":20,"collaborators":11,"id":24,"slug":25,"hasResults":26,"nctId":27,"briefTitle":28,"officialTitle":29,"acronym":30,"eligibilityCriteria":31,"healthyVolunteers":32,"sex":33,"minAge":34,"maxAge":35,"enrollmentInfo":36,"targetDuration":11,"studyType":39,"phases":40,"briefSummary":42,"conditions":43,"keywords":46,"overallStatus":50,"whyStopped":11,"lastUpdateSubmitDate":51,"lastUpdatePostDateStruct":52,"startDateStruct":55,"completionDateStruct":57,"leadSponsor":59,"locationsCount":11},{"fullName":5,"class":6},"Massachusetts General Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Patients under creatine monohydrate intervention","EXPERIMENTAL",null,[13],"Dietary Supplement: Creatine monohydrate",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":11},"DIETARY_SUPPLEMENT","Creatine monohydrate","Participants will receive creatine supplementation before surgery",[9],{"type":21,"investigatorFullName":22,"investigatorTitle":23,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Susana Vacas, MD, PhD","Associate Professor","100616779","creatine-and-perioperative-brain-health-100616779",false,"NCT07310043","Creatine and Perioperative Brain Health","Creatine Intervention in Older Adults to Improve Perioperative Brain Health","CREATE","Inclusion Criteria:\n\n* Patients scheduled for elective surgery under general anesthesia\n\nExclusion Criteria:\n\n* History of creatine deficiency disorders\n* Severe neurologic or psychiatric diseases\n* History of stroke or head trauma\n* Obesity (BMI ≥ 30 kg.m-²), kidney or liver disease",true,"ALL","60 Years","75 Years",{"count":37,"type":38},80,"ESTIMATED","INTERVENTIONAL",[41],"NA","The goal of this study is to understand the effects of oral creatine supplementation in the perioperative period. Creatine is commonly used to enhance athletic performance, but it can also have positive effects on the brain. Since surgery can lead to alterations in thinking, memory, and attention patterns in some patients, we will assess whether creatine can be protective against these changes in older adults undergoing surgery.",[44,45],"Neurocognitive Disorders","Postoperative Delirium",[47,48,49],"Perioperative Brain Health","Creatine","Perioperative Neurocognitive Disorders","NOT_YET_RECRUITING","2026-04-19",{"date":53,"type":54},"2026-04-21","ACTUAL",{"date":56,"type":38},"2026-07-01",{"date":58,"type":38},"2028-06-30",{"name":5,"class":6}]