[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100639174":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":34,"locations":25,"responsibleParty":43,"collaborators":47,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":55,"sex":61,"minAge":62,"maxAge":25,"enrollmentInfo":63,"targetDuration":25,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":74,"overallStatus":79,"whyStopped":25,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":25},{"fullName":5,"class":6},"Pavol Jozef Safarik University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Standard Multimodal Opioid-Based Analgesia","ACTIVE_COMPARATOR","Participants will receive standard multimodal opioid-based perioperative analgesia according to institutional cardiac surgery pain management protocols.",[13],"Procedure: Standard Multimodal Opioid-Based Analgesia",{"label":15,"type":16,"description":17,"interventionNames":18},"Regional Anesthesia-Based Analgesia","EXPERIMENTAL","Participants will receive regional anesthesia-based perioperative analgesia including chest wall plane block techniques in combination with multimodal analgesia during cardiac surgery.",[19],"Procedure: Regional Anesthesia-Based Analgesia",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Standard perioperative pain management including opioid-based multimodal analgesia administered according to institutional cardiac surgery protocols.",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"Regional anesthesia-based perioperative analgesia including chest wall plane block techniques such as erector spinae plane block, PECS block, or paravertebral block in combination with multimodal analgesia during cardiac surgery.",[15],[30],{"name":31,"affiliation":32,"role":33},"Peter Kostic, MD, PhD","Department of Heart and Lung Diseases, Unit for Cardiothoracic Surgery, Anesthesia and Intensive Care, Uppsala University Hospital, 751 85 Uppsala, Sweden","STUDY_CHAIR",[35,40],{"name":36,"role":37,"phone":38,"phoneExt":25,"email":39},"Ladislav Kočan, assoc. prof, MD, PhD","CONTACT","+421557891110","lkocan@vusch.sk",{"name":41,"role":37,"phone":25,"phoneExt":25,"email":42},"Peter Kostič, MD PhD","peter.kostic@uu.se",{"type":44,"investigatorFullName":45,"investigatorTitle":46,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"SPONSOR_INVESTIGATOR","Kočan Ladislav","Principal Investigator and Study Chair",[48,51],{"name":49,"class":50},"East Slovakia Institute of Cardiovascular Diseases in Košice, Slovakia","UNKNOWN",{"name":52,"class":6},"Uppsala University Hospital","100639174","crops-study-chronification-of-post-surgical-pain-and-risk-assessment-100639174",false,"NCT07629453","CROPS Study: Chronification of Post-Surgical Pain and Risk Assessment","Chronification of Post-Surgical Pain and Validation of a Novel Risk Assessment Tool: A Prospective Multicenter Randomized Controlled Trial","CROPS","Inclusion Criteria:\n\n* Age ≥18 years\n* Elective cardiac surgery requiring median sternotomy, including:\n* coronary artery bypass grafting (CABG)\n* aortic valve replacement or repair\n* mitral valve replacement or repair\n* ascending aorta surgery\n* Ability to understand study information\n* Ability to provide written informed consent\n* Expected postoperative hospital stay longer than 3 days\n* Availability for follow-up at 1 week and 3 months after surgery\n\nExclusion Criteria:\n\n* Emergency surgery\n* Cognitive impairment preventing study participation\n* Serious psychiatric illness interfering with study participation\n* Language barrier preventing questionnaire completion\n* Participation in another interventional study affecting pain outcomes\n* Reoperation for postoperative bleeding\n* Severe chronic renal failure\n* Allergy or contraindication to study medication or regional anesthesia techniques\n* Pregnancy or breastfeeding\n* Chronic opioid therapy exceeding 60 mg morphine equivalents daily\n* Extensive emergency aortic surgery (e.g., Thoraflex implantation for acute aortic dissection)","ALL","18 Years",{"count":64,"type":65},180,"ESTIMATED","INTERVENTIONAL",[68],"NA","Chronic post-surgical pain (CPSP) represents a major clinical problem associated with impaired functional recovery, reduced quality of life, prolonged opioid use, and increased healthcare utilization. The mechanisms underlying pain chronification are multifactorial and involve complex interactions among surgical trauma, inflammatory responses, central sensitization, neuroimmune activation, and psychosocial risk factors.\n\nThe CROPS study (Chronification of Post-Surgical Pain and Risk Assessment) is a prospective multicenter randomized controlled trial designed to evaluate the impact of perioperative analgesic strategies on the development of chronic post-surgical pain and to validate a novel questionnaire-based pain chronification risk assessment tool in adult patients undergoing cardiac surgery.\n\nParticipants will be randomized to receive either standard multimodal opioid-based perioperative analgesia or regional anesthesia-based perioperative analgesia incorporating chest wall plane block techniques, including erector spinae plane block, paravertebral block, or PECS block, according to institutional practice.\n\nThe study will compare postoperative pain intensity, opioid consumption, postoperative recovery, postoperative complications, health-related quality of life, and the incidence of chronic post-surgical pain at 3 months after surgery. In parallel, the predictive performance of the pain chronification risk assessment questionnaire will be evaluated using discrimination and calibration analyses.\n\nThe study is conducted as an investigator-initiated academic collaboration between the East Slovakia Institute of Cardiovascular Diseases, Košice, Slovakia, and Uppsala University Hospital, Uppsala, Sweden.",[71,72,73],"Chronic Post-surgical Pain","Acute Postoperative Pain","Cardiac Surgery",[75,76,77,78],"chronic post-surgical pain","cardiac surgery","regional anesthesia","postoperative analgesia","NOT_YET_RECRUITING","2026-06-04",{"date":82,"type":83},"2026-06-05","ACTUAL",{"date":85,"type":65},"2026-09-01",{"date":87,"type":65},"2029-06-01",{"name":45,"class":6}]