[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100583803":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":45,"responsibleParty":76,"collaborators":26,"id":79,"slug":80,"hasResults":81,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":26,"eligibilityCriteria":85,"healthyVolunteers":81,"sex":86,"minAge":87,"maxAge":26,"enrollmentInfo":88,"targetDuration":26,"studyType":91,"phases":92,"briefSummary":94,"conditions":95,"keywords":97,"overallStatus":48,"whyStopped":26,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},{"fullName":5,"class":6},"Tanta University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"cross-section band ligation","EXPERIMENTAL","160 cirrhotic patients with endoscopic evidence of medium\u002Flarge-sized esophageal varices undergoing endoscopic prophylaxis using the cross-section band ligation technique.",[13],"Procedure: endoscopic band ligation with cross-section technique",{"label":15,"type":16,"description":17,"interventionNames":18},"stepladder band ligation","ACTIVE_COMPARATOR","160 cirrhotic patients with endoscopic evidence of medium\u002Flarge-sized esophageal varices undergoing endoscopic prophylaxis using the step ladder band ligation technique.",[19],"Procedure: Endoscopic band ligation using stepladder technique",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","endoscopic band ligation with cross-section technique","Endoscopic band ligation (EBL) of medium\u002Flarge-sized esophageal varices using the cross-section banding technique. EBL will be repeated every two to four weeks until eradication. After eradication of varices, endoscopy will be repeated after 3- 6 months to check for variceal recurrence, evaluation of treatment-related side effects, bleeding rates, and mortality from EBL treatment.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Endoscopic band ligation using stepladder technique","Endoscopic band ligation (EBL) of medium\u002Flarge-sized esophageal varices using the stepladder banding technique. EBL will be repeated every two to four weeks until eradication. After eradication of varices, endoscopy will be repeated after 3- 6 months to check for variceal recurrence, evaluation of treatment-related side effects, bleeding rates, and mortality from EBL treatment",[15],[32],{"name":33,"affiliation":34,"role":35},"Nabila A Elgazzar, MD","Tropical medicine and infectious diseases Department, Faculty of Medicine, Tanta University","PRINCIPAL_INVESTIGATOR",[37,42],{"name":38,"role":39,"phone":40,"phoneExt":26,"email":41},"Rania M Elkafoury, MD","CONTACT","+201004672358","rania.elkafoury@med.tanta.edu.eg",{"name":33,"role":39,"phone":43,"phoneExt":26,"email":44},"00201288585733","nabilaelgazzar@med.tanta.edu.eg",[46],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"Tanta University Hospitals","RECRUITING","Tanta","Gharbyea","31516","Egypt","EG",{"type":55,"coordinates":56},"Point",[57,58],31.00192,30.78847,{"lat":58,"lon":57},[61,65,67,68,70,72,74],{"name":62,"role":39,"phone":63,"phoneExt":26,"email":64},"Dina H Ziada, MD","00201117109990","dina.ziada@med.tanta.edu.eg",{"name":26,"role":39,"phone":26,"phoneExt":26,"email":66},"dr_ranon3000@yahoo.com",{"name":33,"role":35,"phone":26,"phoneExt":26,"email":26},{"name":38,"role":69,"phone":26,"phoneExt":26,"email":26},"SUB_INVESTIGATOR",{"name":71,"role":69,"phone":26,"phoneExt":26,"email":26},"Amal M Dwidar, MD",{"name":73,"role":69,"phone":26,"phoneExt":26,"email":26},"Eslam S Ismaiel, MD",{"name":75,"role":35,"phone":26,"phoneExt":26,"email":26},"Assem A Elfert, MD",{"type":35,"investigatorFullName":77,"investigatorTitle":78,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Rania Mamdouh Elkafoury","Lecturer of Tropical Medicine","100583803","cross-section-band-ligation-versus-stepladder-band-ligation-of-esophageal-varices-100583803",false,"NCT06881082","Cross-section Band Ligation Versus Stepladder Band Ligation of Esophageal Varices","Cross-section Band Ligation Versus Stepladder Band Ligation Techniques in Prophylaxis of Esophageal Varices in Cirrhotic Liver Disease. A Randomized Controlled Trial.","Inclusion Criteria:\n\n* Aged \\>18 years.\n* Cirrhotic patients.\n* Endoscopic evidence of medium\u002Flarge-sized esophageal varices.\n\nExclusion Criteria:\n\n* History of variceal bleeding or previous primary prevention of varices.\n* Portal vein thrombosis or previous porto-systemic shunts as TIPS.\n* Patients on drugs affecting portal pressure (beta blockers, nitrates).\n* Advanced cardiovascular disease including acute myocardial infarction, atrio-ventricular block, congestive heart failure, chronic peripheral ischemia, and severe bradycardia.\n* Patients with severe respiratory diseases (COPD, bronchial asthma).\n* Uncontrolled diabetes mellitus.\n* Renal impairment.\n* Hepatocellular carcinoma.\n* Allergy to carvedilol.\n* Pregnancy or lactation.","ALL","18 Years",{"count":89,"type":90},320,"ESTIMATED","INTERVENTIONAL",[93],"NA","The goal of this randomized controlled trial is to evaluate the cross-section band ligation technique versus the stepladder band ligation technique in esophageal varices prophylaxis.\n\nResearchers will compare cross-section and step ladder band ligation techniques for esophageal varices prophylaxis regarding efficacy, side effects, variceal recurrence, and survival.\n\nParticipants will undergo history-taking, clinical examination, laboratory investigations, and upper endoscopy. Index upper endoscopy will be performed to evaluate the presence, size, and grade of esophageal varices. Patients will be randomly assigned to endoscopic band ligation (EBL) either by cross-section or stepladder techniques every two to four weeks until eradication. After eradication of varices, endoscopy will be repeated after 3-6 months to check for variceal recurrence. For a period of 6 months, all patients in the treatment groups will be followed up every 3 months with clinic visits, including laboratory testing, evaluation of treatment-related side effects, bleeding rates, and mortality from EBL treatment.",[96],"Esophageal Varices",[98,99],"Band ligation","esophageal varices prophylaxis","2025-03-11",{"date":102,"type":103},"2025-03-18","ACTUAL",{"date":105,"type":103},"2024-12-01",{"date":107,"type":90},"2025-12-30",{"name":5,"class":6},1]