[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100626318":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":10,"centralContacts":27,"locations":10,"responsibleParty":33,"collaborators":10,"id":35,"slug":36,"hasResults":37,"nctId":38,"briefTitle":39,"officialTitle":39,"acronym":10,"eligibilityCriteria":40,"healthyVolunteers":41,"sex":42,"minAge":43,"maxAge":44,"enrollmentInfo":45,"targetDuration":48,"studyType":49,"phases":10,"briefSummary":50,"conditions":51,"keywords":10,"overallStatus":54,"whyStopped":10,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":56,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":10},{"fullName":5,"class":6},"Shanghai Yueyang Integrated Medicine Hospital","OTHER",[8,13,16,19],{"label":9,"type":10,"description":10,"interventionNames":11},"Psoriasis subjects",null,[12],"Other: Questionnaire collection",{"label":14,"type":10,"description":10,"interventionNames":15},"Atopic dermatitis subjects",[12],{"label":17,"type":10,"description":10,"interventionNames":18},"Urticaria subjects",[12],{"label":20,"type":10,"description":10,"interventionNames":21},"Healthy controls",[12],[23],{"type":6,"name":24,"description":25,"armGroupLabels":26,"otherNames":10},"Questionnaire collection","During the study visit investigators will conduct face-to-face interviews and collect the questionnaire data, with confirmation from family members where appropriate.",[14,20,9,17],[28],{"name":29,"role":30,"phone":31,"phoneExt":10,"email":32},"Xin Li, PhD","CONTACT","13661956326","13661956326@163.com",{"type":34,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100626318","cross-sectional-study-for-an-ocular-imaging-based-predictive-model-of-inflammatory-skin-diseases-grounded-in-traditional-chinese-medicine-100626318",false,"NCT07434076","Cross-Sectional Study for an Ocular Imaging-Based Predictive Model of Inflammatory Skin Diseases Grounded in Traditional Chinese Medicine","Inclusion Criteria:\n\nFor patients with inflammatory skin disease:\n\nClinical diagnosis of one of the three target inflammatory skin diseases (psoriasis, atopic dermatitis, or urticaria).\n\nAge ≥ 18 and ≤ 65 years, any sex.\n\nUnderstands and signs informed consent.\n\nFor healthy controls:\n\nDo not meet diagnostic criteria for any of the three inflammatory skin diseases above.\n\nAge ≥ 18 and ≤ 65 years, any sex.\n\nUnderstands and signs informed consent.\n\nExclusion Criteria:\n\nFor patients with inflammatory skin disease:\n\nExclude any subject meeting any of the following:\n\nRefusal to undergo examinations.\n\nPresence of acute\u002Factive infectious ocular disease (e.g., viral keratoconjunctivitis).\n\nCorneal perforation or high-risk perforation where contact procedures cause severe photophobia, eye pain, inability to keep eyes open or fixate.\n\nNystagmus or other conditions that prevent fixation.\n\nPupillary non-dilation (e.g., posterior synechiae) that precludes fundus imaging.\n\nSevere eyelid lesions (e.g., marked swelling, ectropion, entropion) that prevent globe exposure.\n\nParticipation in other clinical trials within the previous 3 months or concurrent participation in other interventional studies.\n\n* Healthy control - exclusion criteria\n\nExclude any subject meeting any of the following:\n\nPresence of other skin diseases that could affect study assessments (e.g., atopic dermatitis, urticaria, scabies).\n\nRefusal to undergo examinations.\n\nAcute\u002Factive infectious ocular disease (e.g., viral keratoconjunctivitis).\n\nCorneal perforation or high-risk perforation that causes severe photophobia, eye pain, inability to keep eyes open or fixate during contact procedures.\n\nNystagmus or other reasons preventing fixation.\n\nPupillary non-dilation (e.g., posterior synechiae) that prevents fundus imaging.\n\nParticipation in other clinical studies within the previous 3 months or currently participating in other clinical trials.",true,"ALL","18 Years","65 Years",{"count":46,"type":47},950,"ESTIMATED","1 Day","OBSERVATIONAL","This study is a cross-sectional, observational investigation designed to develop and validate a noninvasive ocular imaging-based predictive model for major inflammatory skin diseases, including psoriasis, atopic dermatitis, and urticaria. Grounded in Traditional Chinese Medicine (TCM) ocular diagnostic theory and integrated with advanced computer vision techniques, the study aims to establish objective, quantifiable biomarkers derived from scleral and bulbar conjunctival images.\n\nApproximately 950 participants (patients with psoriasis, atopic dermatitis, urticaria, and healthy controls) will be recruited from a tertiary academic hospital. Standardized high-resolution ocular images will be collected alongside comprehensive clinical, demographic, and comorbidity data. Disease severity will be assessed using validated clinical scoring systems (e.g., PASI, EASI, UAS7, DLQI).\n\nImage analysis will combine traditional radiomics feature extraction with deep learning architectures, including a Vision State-Space (VMamba) module for global-local feature representation and a Multi-Gate Mixture-of-Experts (MMoE) framework for multi-task learning. The model is designed to simultaneously perform disease classification and predict comorbidity risks (such as metabolic syndrome, hepatic insulin resistance, and recurrence risk).\n\nPrimary outcomes include characterization of ocular feature patterns associated with inflammatory skin diseases. Secondary outcomes include correlations between ocular image-derived features and clinical severity indices. Model performance will be evaluated using ROC curves, AUC, calibration analysis, and decision curve analysis.\n\nThis study aims to provide an objective, digitalized, and clinically applicable ocular biomarker framework to support early diagnosis, risk stratification, and comorbidity screening in inflammatory skin diseases.",[52,53],"Psoriasis","Atopic Dermatitis","NOT_YET_RECRUITING","2026-02-19",{"date":57,"type":58},"2026-02-25","ACTUAL",{"date":60,"type":47},"2026-03-05",{"date":62,"type":47},"2028-05-25",{"name":5,"class":6}]