[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100623552":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":31,"responsibleParty":80,"collaborators":84,"id":89,"slug":90,"hasResults":91,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":95,"eligibilityCriteria":96,"healthyVolunteers":91,"sex":97,"minAge":98,"maxAge":20,"enrollmentInfo":99,"targetDuration":20,"studyType":102,"phases":103,"briefSummary":105,"conditions":106,"keywords":109,"overallStatus":119,"whyStopped":20,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":129},{"fullName":5,"class":6},"St. Antonius Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Cryoablation","EXPERIMENTAL","Participants receive image-guided percutaneous cryoablation as a single primary treatment for early-stage breast cancer. Cryoablation is performed to destroy the tumour by freezing, without surgical excision of the primary tumour.",[13],"Procedure: Cryoablation \u002F Cryotherapy",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"PROCEDURE","Cryoablation \u002F Cryotherapy","Cryoablation is performed as a percutaneous, image-guided procedure in which the breast tumour is destroyed by controlled freezing. One or more cryoprobes are placed into the tumour under imaging guidance, and freezing cycles are applied to achieve complete local tumour ablation. The procedure is performed as a single intervention without surgical excision of the primary tumour.",[9],null,[22,27],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"Iza Stekelenburg, MD","CONTACT","+31657835198","i.stekelenburg@antoniusziekenhuis.nl",{"name":28,"role":24,"phone":29,"phoneExt":20,"email":30},"Annemiek Doeksen, MD, PhD","+31 616608284","a.doeksen@antoniusziekenhuis.nl",[32,50,65],{"facility":33,"status":20,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Rijnstate Hospital","Arnhem","Gelderland","6836 BH","Netherlands","NL",{"type":40,"coordinates":41},"Point",[42,43],5.91111,51.98,{"lat":43,"lon":42},[46],{"name":47,"role":24,"phone":48,"phoneExt":20,"email":49},"Ramon van Eekeren, MD, PhD","+3164824542","rvaneekeren@rijnstate.nl",{"facility":51,"status":20,"city":52,"state":53,"zip":54,"country":37,"countryCode":38,"cosmosGeoPoint":55,"geoPoint":59,"contacts":60},"Amphia Hospital","Breda","North Brabant","4818 CK",{"type":40,"coordinates":56},[57,58],4.77596,51.58656,{"lat":58,"lon":57},[61],{"name":62,"role":24,"phone":63,"phoneExt":20,"email":64},"Eliane CM Zeestraten, MD, PhD","+3123421369","EZeestraten@amphia.nl",{"facility":66,"status":20,"city":67,"state":68,"zip":69,"country":37,"countryCode":38,"cosmosGeoPoint":70,"geoPoint":74,"contacts":75},"Antoni van Leeuwenhoek - Nederlands Kanker Instituut","Amsterdam","North Holland","1066 CX",{"type":40,"coordinates":71},[72,73],4.88969,52.37403,{"lat":73,"lon":72},[76],{"name":77,"role":24,"phone":78,"phoneExt":20,"email":79},"Frederieke van Duijnhoven, MD, PhD","+31619874388","f.v.duijnhoven@nki.nl",{"type":81,"investigatorFullName":82,"investigatorTitle":83,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"PRINCIPAL_INVESTIGATOR","Iza Stekelenburg","Coordinating investigator",[85,86,87],{"name":51,"class":6},{"name":33,"class":6},{"name":88,"class":6},"Antoni van Leeuwenhoek Hospital","100623552","cryo-1-cryoablation-in-elderly-patients-with-early-stage-breast-cancer-100623552",false,"NCT07398118","CRYO-1: Cryoablation in Elderly Patients With Early-Stage Breast Cancer.","Treatment of Elderly Patients With Early Stage Breast Cancer (CRYO-1): The Efficacy of Cryoablation In The Elderly - A Phase II Multicentre, Feasibility Study.","CRYO-1","Inclusion Criteria:\n\n* Age ≥ 70 years\n* Histologically confirmed invasive breast cancer\n* Clinical stage cT1N0M0 based on mammography and ultrasound ER-positive, HER2-negative (IHC 0-1+ or 2+ with negative ISH), any PR status\n* Presence of concurrent DCIS is allowed if limited to \\\u003C25% of the pre-NST biopsy, with no radiologic suspicion of an extensive component\n* Unifocal disease \\\u003C2 cm, well visualized on ultrasound, with a minimum distance of ≥5 mm from the skin, nipple and thoracic wall\n* Ability and willingness to comply with project requirements\n* Preoperative endocrine therapy is allowed\n* Written informed consent given by the subject\n\nExclusion Criteria:\n\n* Pure DCIS lesions without invasive component\n* Extensive calcifications on imaging suggestive of widespread disease\n* Invasive lobular carcinoma (as assessed by IHC)\n* Triple-negative or HER2-positive subtype (defined as (IHC 3+ or ISH positive)\n* History of ipsilateral breast cancer or DCIS\n* Prior ipsilateral radiotherapy\n* Inability to communicate in Dutch or English language\n* Planned (e)migration or long-term stay abroad within one year after inclusion","FEMALE","70 Years",{"count":100,"type":101},61,"ESTIMATED","INTERVENTIONAL",[104],"NA","This study looks at a new way to treat early-stage breast cancer in older adults using a freezing technique called cryoablation.\n\nOlder adults with early-stage breast cancer are usually treated with surgery or primary endocrine therapy (hormone therapy). While these treatments can be effective, they may also be burdensome. Surgery can lead to pain, slow recovery, or complications, and primary endocrine therapy often requires long-term medication and may cause side effects or stop working over time. Cryoablation may offer a less invasive treatment option.\n\nThe goal of this study is to find out whether cryoablation can be safely and successfully used as the main treatment for older adults with early-stage breast cancer. Cryoablation destroys the tumour by freezing it. The procedure is performed through the skin using imaging guidance and does not involve surgical removal of the tumour.\n\nParticipants in this study are adults aged 70 years or older who have a small breast tumour that has not spread to the lymph nodes. All participants receive cryoablation as a single treatment.\n\nAfter the procedure, participants are followed closely. Researchers will collect information on side effects, recovery, whether additional treatment is needed, and how participants experience the treatment. Quality of life will also be assessed.\n\nThis study is carried out in several hospitals. All participants must give written informed consent before taking part. The results of this study may help determine whether cryoablation could be a safe and practical treatment option for older adults with early-stage breast cancer and guide future research.",[107,108],"Breast Cancer Stage I","Breast Cancer Early Stage Breast Cancer (Stage 1-3)",[9,110,111,112,113,114,115,116,117,118],"Early-stage breast cancer","Non-curative","Elderly","Minimally invasive treatment","Breast tumour","Local tumour control","Feasibility study","Cryotherapy","Non-surgical treatment","NOT_YET_RECRUITING","2026-03-20",{"date":122,"type":123},"2026-03-23","ACTUAL",{"date":125,"type":101},"2026-04-01",{"date":127,"type":101},"2028-06-30",{"name":5,"class":6},3]