[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100526800":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":27,"centralContacts":32,"locations":42,"responsibleParty":117,"collaborators":11,"id":119,"slug":120,"hasResults":121,"nctId":122,"briefTitle":123,"officialTitle":124,"acronym":11,"eligibilityCriteria":125,"healthyVolunteers":121,"sex":126,"minAge":127,"maxAge":11,"enrollmentInfo":128,"targetDuration":11,"studyType":131,"phases":132,"briefSummary":134,"conditions":135,"keywords":11,"overallStatus":66,"whyStopped":11,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":142,"completionDateStruct":144,"leadSponsor":146,"locationsCount":147},{"fullName":5,"class":6},"Duke University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Cryotherapy","EXPERIMENTAL",null,[13],"Behavioral: Cryotherapy",{"label":15,"type":10,"description":11,"interventionNames":16},"Compression with Cryotherapy",[13,17],"Behavioral: Compression",[19,23],{"type":20,"name":9,"description":21,"armGroupLabels":22,"otherNames":11},"BEHAVIORAL","Participants will receive cryotherapy on both hands and feet",[15,9],{"type":20,"name":24,"description":25,"armGroupLabels":26,"otherNames":11},"Compression","Participants will receive compression on both hands and feet",[15],[28],{"name":29,"affiliation":30,"role":31},"Laura Havrilesky","DUHS","PRINCIPAL_INVESTIGATOR",[33,38],{"name":34,"role":35,"phone":36,"phoneExt":11,"email":37},"Amelia Scott","CONTACT","919-613-4584","amelia.lorenzo@duke.edu",{"name":39,"role":35,"phone":40,"phoneExt":11,"email":41},"Mary K Anastasio","225-603-7972","mm765@duke.edu",[43,64,81,97],{"facility":44,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Hartford Healthcare Cancer Institute","NOT_YET_RECRUITING","Hartford","Connecticut","06106","United States","US",{"type":52,"coordinates":53},"Point",[54,55],-72.68509,41.76371,{"lat":55,"lon":54},[58,62],{"name":59,"role":35,"phone":60,"phoneExt":11,"email":61},"Corey Glider","860-972-5019","Corey.Glider@hhchealth.org",{"name":63,"role":31,"phone":11,"phoneExt":11,"email":11},"Amy Brown, MD",{"facility":65,"status":66,"city":67,"state":47,"zip":68,"country":49,"countryCode":50,"cosmosGeoPoint":69,"geoPoint":73,"contacts":74},"Middlesex Health Cancer Center - Middletown","RECRUITING","Middletown","06457",{"type":52,"coordinates":70},[71,72],-72.65065,41.56232,{"lat":72,"lon":71},[75,79],{"name":76,"role":35,"phone":77,"phoneExt":11,"email":78},"Loriann MacLean, MSN","860-358-2015","loriann.maclean@midhosp.org",{"name":80,"role":31,"phone":11,"phoneExt":11,"email":11},"Karthikeyan Kandevelou, MD",{"facility":82,"status":66,"city":83,"state":84,"zip":85,"country":49,"countryCode":50,"cosmosGeoPoint":86,"geoPoint":90,"contacts":91},"Duke University Medical Center","Durham","North Carolina","27710",{"type":52,"coordinates":87},[88,89],-78.89862,35.99403,{"lat":89,"lon":88},[92,96],{"name":93,"role":35,"phone":94,"phoneExt":11,"email":95},"Laura Havrilesky, MD","919-684-0126","laura.havrilesky@duke.edu",{"name":93,"role":31,"phone":11,"phoneExt":11,"email":11},{"facility":98,"status":66,"city":99,"state":100,"zip":101,"country":49,"countryCode":50,"cosmosGeoPoint":102,"geoPoint":106,"contacts":107},"Carilion Clinic","Roanoke","Virginia","24016",{"type":52,"coordinates":103},[104,105],-79.94143,37.27097,{"lat":105,"lon":104},[108,112,116],{"name":109,"role":35,"phone":110,"phoneExt":11,"email":111},"Danielle Mitchell","540-521-1355","dmmitchell@carilionclinic.org",{"name":113,"role":35,"phone":114,"phoneExt":11,"email":115},"Erin Saks, MD","(540) 581-0160","ejsaks@carilionclinic.org",{"name":113,"role":31,"phone":11,"phoneExt":11,"email":11},{"type":118,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100526800","cryocompression-to-reduce-chemotherapy-induced-peripheral-neuropathy-in-gynecologic-cancer---cohort-2-100526800",false,"NCT06139458","Cryocompression to Reduce Chemotherapy-induced Peripheral Neuropathy in Gynecologic Cancer - COHORT 2","Use of Cryocompression to Reduce Chemotherapy-induced Peripheral Neuropathy in Gynecologic Cancer: a Randomized Controlled Trial - COHORT 2","Inclusion Criteria:\n\n* Gynecologic cancer diagnosis (ovarian, cervical, endometrial cancer; adenocarcinomas of likely primary gynecologic origin based on cytology or FNA in conjunction with radiologic impression will be eligible)\n* Plan to receive at least 6 cycles of paclitaxel administered every 3 weeks at the Duke Cancer Center or Macon Pond or at the Carilion Clinic in Roanoke, VA. Patients receiving neoadjuvant chemotherapy with a plan for interval debulking will be eligible.\n* ECOG (Eastern Cooperative Oncology Group) performance status of 0-1\n\nExclusion Criteria:\n\n* Treated with prior neurotoxic chemotherapeutic agents\n* Baseline diagnosis of peripheral neuropathy such as diabetic neuropathy, or conditions including but not limited to fibromyalgia, cryoglobulinemia and Raynaud's disease.","FEMALE","18 Years",{"count":129,"type":130},190,"ESTIMATED","INTERVENTIONAL",[133],"NA","The investigators aim to determine the effect of cryotherapy wraps plus compression therapy (henceforth referred to as cryocompression) versus cryotherapy wraps alone on the incidence and degree of chemotherapy-induced peripheral neuropathy in patients with gynecologic cancer using a noninferiority design. The investigators also aim to determine the effect of cryocompression versus cryotherapy on patient tolerability and patient and staff satisfaction.",[136,137],"Gynecologic Cancer","Chemotherapy-induced Peripheral Neuropathy","2026-06-01",{"date":140,"type":141},"2026-06-02","ACTUAL",{"date":143,"type":141},"2024-01-18",{"date":145,"type":130},"2027-05-31",{"name":5,"class":6},4]