[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100534655":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":53,"collaborators":56,"id":83,"slug":84,"hasResults":85,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":89,"eligibilityCriteria":90,"healthyVolunteers":85,"sex":91,"minAge":92,"maxAge":93,"enrollmentInfo":94,"targetDuration":26,"studyType":97,"phases":98,"briefSummary":100,"conditions":101,"keywords":26,"overallStatus":39,"whyStopped":26,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":116},{"fullName":5,"class":6},"The First Affiliated Hospital with Nanjing Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"CSP group","EXPERIMENTAL","In this group, CSP lead is attempted to be placed, including LBBP and HBP.",[13],"Device: Conduction system pacing",{"label":15,"type":16,"description":17,"interventionNames":18},"BiVP group","ACTIVE_COMPARATOR","In this group, traditional RA lead , RV lead and LV lead are attempted to be placed.",[19],"Device: Biventricular pacing",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Conduction system pacing","Firstly, we will attempt LBBP if the patient is allocated to the experimental group. If we can not achieve LBBP successfully, then we will turn to attempt HBP.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Biventricular pacing","Implantation of RA lead, RV lead and LV lead are attempted using the standard-of-care technique.",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Jiangang Zou","CONTACT","86-13605191407","jgzou@njmu.edu.cn",[38],{"facility":5,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"RECRUITING","Nanjing","Jiangsu","210029","China","CN",{"type":46,"coordinates":47},"Point",[48,49],118.77778,32.06167,{"lat":49,"lon":48},[52],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},{"type":54,"investigatorFullName":33,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Head of Internal Medicine",[57,59,61,63,65,67,69,71,73,75,77,79,81],{"name":58,"class":6},"Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University",{"name":60,"class":6},"The First Affiliated Hospital of Soochow University",{"name":62,"class":6},"The Affiliated Hospital of Xuzhou Medical University",{"name":64,"class":6},"The Third Affiliated Hospital of Soochow University",{"name":66,"class":6},"Rugao People's Hospital",{"name":68,"class":6},"Nanfang Hospital, Southern Medical University",{"name":70,"class":6},"First Affiliated Hospital, Sun Yat-Sen University",{"name":72,"class":6},"Third Affiliated Hospital, Sun Yat-Sen University",{"name":74,"class":6},"Shantou Central Hospital",{"name":76,"class":6},"Meizhou People's Hospital",{"name":78,"class":6},"Changzhou Second People's Hospital affiliated with Nanjing Medical University",{"name":80,"class":6},"Zhangjiagang First People's Hospital",{"name":82,"class":6},"Huizhou Third People's Hospital, Guangzhou Medical University","100534655","csp-versus-bivp-for-heart-failure-patients-with-rvp-upgraded-to-cardiac-resynchronization-therapy-100534655",false,"NCT06241651","CSP Versus BiVP for Heart Failure Patients With RVP Upgraded to Cardiac Resynchronization Therapy","Conduction System Pacing Versus Biventricular Pacing for Heart Failure Patients With Right Ventricular Pacing Upgraded to Cardiac Resynchronization Therapy: a Prospective Multicenter Non-inferiority Randomized Controlled Study","CSP-UPGRADE","Inclusion Criteria:\n\n1. Patients with symptomatic heart failure (LVEF \\\u003C50%) after right ventricular pacing for at least 3 months;\n2. NYHA class II-IV;\n3. NT-proBNP \\>125pg\u002FmL in patients with sinus rhythm, NT-proBNP \\>250pg\u002FmL in patients with atrial fibrillation;\n4. Right ventricular pacing percentage \\>40%;\n5. Adult patients aged 18-80;\n6. With informed consent signed.\n\nExclusion Criteria:\n\n1. History of acute myocardial infarction within 3 months before enrollment;\n2. Frequent premature ventricular contraction (\\>15%) or malignant ventricular arrhythmia which is difficult to control;\n3. History of valvular heart disease intervention within 3 months before enrollment;\n4. After mechanical tricuspid valve replacement;\n5. Ventricular septal hypertrophy (≥15mm during diastole);\n6. Complex congenital heart disease;\n7. History of heart transplantation;\n8. Enrollment in any other study;\n9. Pregnant or with child-bearing plan;\n10. A life expectancy of less than 12 months.","ALL","18 Years","80 Years",{"count":95,"type":96},66,"ESTIMATED","INTERVENTIONAL",[99],"NA","The present study is a prospective, multicenter, non-inferiority, randomized controlled trail. It aims to investigate whether the efficacy of conduction system pacing (CSP) is non-inferior to biventricular pacing (BiVP) in patients with heart failure and right ventricular pacing (RVP) requiring upgrading to cardiac resynchronization therapy (CRT).",[102,103,104,105,106],"Conduction System Pacing","Biventricular Pacing","Cardiac Resynchronization Therapy","Right Ventricular Pacing","Heart Failure","2026-05-11",{"date":109,"type":110},"2026-05-14","ACTUAL",{"date":112,"type":110},"2024-01-01",{"date":114,"type":96},"2027-03",{"name":5,"class":6},1]