[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100480446":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":32,"locations":40,"responsibleParty":58,"collaborators":60,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":10,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":10,"enrollmentInfo":72,"targetDuration":75,"studyType":76,"phases":10,"briefSummary":77,"conditions":78,"keywords":80,"overallStatus":43,"whyStopped":10,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Singlera Genomics Inc.","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"ctDNA positive",null,"Postoperative ctDNA positive",[13],"Diagnostic Test: a multi-locus blood-based assay",{"label":15,"type":10,"description":16,"interventionNames":17},"ctDNA negative","Postoperative ctDNA negative",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"DIAGNOSTIC_TEST","a multi-locus blood-based assay","Colorectal tumor-specific plasma ctDNA methylation markers detection",[15,9],[25,29],{"name":26,"affiliation":27,"role":28},"KeFeng Ding, Ph.D","Second Affiliated Hospital, School of Medicine, Zhejiang University","STUDY_DIRECTOR",{"name":30,"affiliation":5,"role":31},"Rui Liu, Ph.D","PRINCIPAL_INVESTIGATOR",[33,38],{"name":34,"role":35,"phone":36,"phoneExt":10,"email":37},"HongFeng cao, Ph.D","CONTACT","13957117804","hongfengcao@zju.edu.cn",{"name":30,"role":35,"phone":10,"phoneExt":10,"email":39},"rliu@singleragenomics.com",[41],{"facility":42,"status":43,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Second Affiliated Hospital","RECRUITING","Hangzhou","Zhejiang","310009","China","CN",{"type":50,"coordinates":51},"Point",[52,53],120.16142,30.29365,{"lat":53,"lon":52},[56],{"name":57,"role":35,"phone":36,"phoneExt":10,"email":37},"HongFeng Cao, Ph.D",{"type":59,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[61],{"name":27,"class":62},"OTHER","100480446","ctdna-methylation-application-in-postoperative-relapse-and-adjuvant-chemotherapy-efficacy-evaluation-100480446",false,"NCT05536089","ctDNA Methylation Application in Postoperative Relapse and Adjuvant Chemotherapy Efficacy Evaluation","ctDNA Methylation Used to Monitor Postoperative Relapse and Evaluate Adjuvant Chemotherapy Efficacy in Resected Stage I and Stage II (Without High Risk) Colorectal Cancer After Radical Resection","Inclusion Criteria:\n\n* Patients must have histologically confirmed stage I\u002FII (without high risk) colorectal cancer.\n* Male or female ≥ 18 years of age on the day of signing informed consent.\n* Patients need to receive surgical resection, and with ctDNA positive prior to resection of colorectal cancer (CRC).\n* Patients must have a performance status of ≤1 on the Eastern Cooperative Oncology Group (ECOG) Performance Scale.\n* Written informed consent must be obtained from patient or patient's legal representative and ability for patient to comply with the requirements of the study.\n\nExclusion Criteria:\n\n* Personal history of colorectal cancer, colorectal adenoma or aerodigestive tract cancer.\n* Induction of neoadjuvant systemic therapy prior to resection of CRC.\n* Patient is pregnant or lactating.\n* Patients with a history or current evidence of any condition or abnormality that might confound the results of the study, interfere with the patient's participation for the full duration of the study, or is not in the best interest of the patient to participate, in the opinion of the Investigator.\n* Inadequate tumor material (either quality and quantity) to support circulating tumor DNA (ctDNA) analysis.","ALL","18 Years",{"count":73,"type":74},2000,"ESTIMATED","5 Years","OBSERVATIONAL","In this study, the investigators aimed to apply their previously developed multi-locus blood-based assay targeting circulating tumor DNA methylation to monitor postoperative relapse and evaluate adjuvant chemotherapy efficacy in resected stage I and stage II (without high risk) colorectal cancer after radical resection.",[79],"Cancer Colorectal",[81],"early detection","2024-05-21",{"date":84,"type":85},"2024-05-22","ACTUAL",{"date":87,"type":85},"2022-09-05",{"date":89,"type":74},"2028-12",{"name":5,"class":6},1]