[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100448963":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":12,"centralContacts":17,"locations":24,"responsibleParty":43,"collaborators":7,"id":46,"slug":47,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":48,"sex":54,"minAge":55,"maxAge":7,"enrollmentInfo":56,"targetDuration":59,"studyType":60,"phases":7,"briefSummary":61,"conditions":62,"keywords":66,"overallStatus":27,"whyStopped":7,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"Abramson Cancer Center at Penn Medicine","OTHER",null,[9],{"type":6,"name":10,"description":11,"armGroupLabels":7,"otherNames":7},"Collection of personal and family history from CAFÉ Study participants","Personal medical and genetic history, as well as relevant information about family history, will be collected from participants in the CAFÉ Study through an online data entry system",[13],{"name":14,"affiliation":15,"role":16},"Bryson W Katona, MD, PhD","University of Pennsylvania","PRINCIPAL_INVESTIGATOR",[18,22],{"name":14,"role":19,"phone":20,"phoneExt":7,"email":21},"CONTACT","215-349-8222","cafestudy@pennmedicine.upenn.edu",{"name":23,"role":19,"phone":7,"phoneExt":7,"email":21},"Dana Farengo Clark, MS, LCGC",[25],{"facility":26,"status":27,"city":28,"state":29,"zip":30,"country":31,"countryCode":32,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"Abramson Cancer Center of the University of Pennsylvania","RECRUITING","Philadelphia","Pennsylvania","19104","United States","US",{"type":34,"coordinates":35},"Point",[36,37],-75.16362,39.95238,{"lat":37,"lon":36},[40,42],{"name":41,"role":19,"phone":20,"phoneExt":7,"email":21},"Bryson Katona, MD, PhD",{"name":41,"role":16,"phone":7,"phoneExt":7,"email":7},{"type":16,"investigatorFullName":44,"investigatorTitle":45,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"Bryson Katona","Assistant Professor of Medicine, Director - Gastrointestinal Cancer Genetics Program","100448963","ctnna1-familial-expansion-study-100448963",false,"NCT05126290","CTNNA1 Familial Expansion Study","CTNNA1 Familial Expansion (CAFÉ) Study","CAFÉ","Inclusion Criteria:\n\n* 18 years of age and older\n* Participants must be carrier, or a first degree relative of a carrier, of a CTNNA1 loss-of-function variant defined as: a variant predicted to lead to protein truncation (nonsense and frameshift variants), a large deletion of one or more exons, or a consensus splice site variant predicted to disrupt splicing in CTNNA1. CTNNA1 loss-of-function variants do not need to be classified as pathogenic or likely pathogenic to be included.\n* Participants must be able to understand and read English\n* Participants must be able to provide informed verbal or written consent\n\nExclusion Criteria:\n\n* Less than 18 years of age\n* Individuals who do not carry a CTNNA1 loss-of-function variant and are not a first degree relative of a CTNNA1 loss-of-function variant carrier.\n* Individuals who cannot speak and read English\n* Major psychiatric illness or cognitive impairment that in the judgement of the study investigators or study staff would preclude study participation\n* Unable to comply with the study procedures as determined by the study investigators or study staff","ALL","18 Years",{"count":57,"type":58},100,"ESTIMATED","1 Year","OBSERVATIONAL","The goal of the CAFÉ Study is to determine the cancer risks associated with germline CTNNA1 loss-of-function variants.",[63,64,65],"Cancer Gene Mutation","Gastric Cancer","Breast Cancer",[67,68,69,70],"CTNNA1","Hereditary diffuse gastric cancer","Gastric cancer","Breast cancer","2026-02-03",{"date":73,"type":74},"2026-02-05","ACTUAL",{"date":76,"type":74},"2021-03-16",{"date":78,"type":58},"2028-01-01",{"name":5,"class":6},1]