[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100610544":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":19,"locations":10,"responsibleParty":26,"collaborators":28,"id":33,"slug":34,"hasResults":35,"nctId":36,"briefTitle":37,"officialTitle":38,"acronym":39,"eligibilityCriteria":40,"healthyVolunteers":41,"sex":42,"minAge":43,"maxAge":44,"enrollmentInfo":45,"targetDuration":10,"studyType":48,"phases":10,"briefSummary":49,"conditions":50,"keywords":54,"overallStatus":61,"whyStopped":10,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":10},{"fullName":5,"class":6},"King's College London","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Healthy babies",null,"Babies up to 6 months old without eczema",{"label":13,"type":10,"description":14,"interventionNames":10},"Babies with Eczema","Babies up to 6 months old with eczema",[16],{"name":17,"affiliation":5,"role":18},"Carsten Flohr","PRINCIPAL_INVESTIGATOR",[20],{"name":21,"role":22,"phone":23,"phoneExt":24,"email":25},"Preeti Khurana","CONTACT","020 7188 7188","57716","gstt.carestudy@nhs.net",{"type":27,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[29,31],{"name":30,"class":6},"Guy's and St Thomas' NHS Foundation Trust",{"name":32,"class":6},"Engineering and Physical Sciences Research Council, UK","100610544","cutaneous-biomarkers-in-atopic-eczema-using-a-non-invasive-micro-suction-device-in-babies-100610544",false,"NCT07228962","Cutaneous Biomarkers in Atopic Eczema Using a Non-Invasive Micro-Suction Device in Babies","Using a Non-invasive Micro-suction Biomarker Extraction Device to Understand Atopic Eczema in Babies","CARE","Inclusion Criteria:\n\n1. Healthy babies and babies with atopic dermatitis up to 6 months old.\n2. Ability of parents\u002Fguardians\u002Fcaregivers to provide written informed consent for study participation.\n3. Willingness of parents\u002Fguardians\u002Fcaregivers to comply with all study requirements.\n4. Parents\u002Fguardians\u002Fcaregivers competent use of English language.\n\nExclusion Criteria:\n\n1. Parents\u002Fguardians\u002Fcaregivers unable to give informed consent.\n2. Preterm birth (defined as birth before 37 completed weeks gestation).\n3. Significant inflammatory skin disease at birth.\n4. Baby has any other serious health issue.",true,"ALL","0 Months","6 Months",{"count":46,"type":47},30,"ESTIMATED","OBSERVATIONAL","This project aims to establish whether an adapted extraction device is tolerable and will be able to measure chemical signals in baby's ISF. Insight into the chemical profiles found in the skin interstitial fluid (ISF) of healthy and diseased babies will identify signals that can be used to investigate the causes of eczema and propose new preventative strategies and effective treatments.\n\nSpecifically, it aims to:\n\n1. Demonstrate that the developed ISF device can be used to extract biomarkers from the skin of babies non-invasively and is tolerable (not causing significant discomfort, bruising, or blister formation).\n2. Compare the profile of chemical markers present in the ISF of healthy babies with babies that have developed eczema.\n3. Compare the biomarker levels extracted from babies with eczema in lesional and non-lesional skin using the developed ISF device.\n4. Compare the microbiome and metabolome profiles from swabs taken from babies with healthy skin and with eczema in lesional and non-lesional skin (exploratory outcome).",[51,52,53],"Eczema","Atopic Dermatitis","Atopic Eczema",[51,52,55,56,57,58,59,60],"Immune System","Skin Barrier","Dermatology","Interstitial Skin Fluid","Microbiome","Early life","NOT_YET_RECRUITING","2026-02-09",{"date":64,"type":65},"2026-02-11","ACTUAL",{"date":67,"type":47},"2026-03-31",{"date":69,"type":47},"2027-06-30",{"name":5,"class":6}]