[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100627214":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":26,"locations":26,"responsibleParty":31,"collaborators":26,"id":35,"slug":36,"hasResults":37,"nctId":38,"briefTitle":39,"officialTitle":40,"acronym":26,"eligibilityCriteria":41,"healthyVolunteers":37,"sex":42,"minAge":43,"maxAge":26,"enrollmentInfo":44,"targetDuration":26,"studyType":47,"phases":48,"briefSummary":50,"conditions":51,"keywords":53,"overallStatus":64,"whyStopped":26,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":26},{"fullName":5,"class":6},"University of Medicine and Pharmacy at Ho Chi Minh City","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Cyanoacrylate Tissue Adhesive","EXPERIMENTAL","Participants undergoing surgical removal of impacted mandibular third molars receive wound closure using cyanoacrylate tissue adhesive applied to the surgical site according to the manufacturer's instructions. Postoperative care and follow-up procedures are standardized across both study conditions.",[13],"Procedure: cyanoacrylate tissue adhesive",{"label":15,"type":16,"description":17,"interventionNames":18},"Conventional Silk Sutures","ACTIVE_COMPARATOR","Participants undergoing surgical removal of impacted mandibular third molars receive conventional wound closure using interrupted silk sutures. Postoperative care and follow-up procedures are identical to those in the cyanoacrylate condition.",[19],"Procedure: Silk Sutures",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","cyanoacrylate tissue adhesive","Following surgical removal of the impacted mandibular third molar, wound closure is achieved by applying cyanoacrylate tissue adhesive along the mucosal margins to approximate the soft tissues without suturing. The adhesive is allowed to polymerize according to the manufacturer's instructions. No sutures are placed at the surgical site. Postoperative care is standardized across study conditions.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Silk Sutures","After surgical removal of the impacted mandibular third molar, wound closure is performed using interrupted non-resorbable silk sutures to approximate the mucosal margins. Sutures are removed at the routine postoperative follow-up visit. Postoperative care is identical to that provided in the cyanoacrylate condition.",[15],{"type":32,"investigatorFullName":33,"investigatorTitle":34,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Bui Nguyen Phuong Thao","Oral Surgeon, Department of Oral Surgery, Faculty of Dentistry","100627214","cyanoacrylate-adhesive-in-impacted-mandibular-third-molars-surgery-100627214",false,"NCT07445724","Cyanoacrylate Adhesive in Impacted Mandibular Third Molars Surgery","Evaluation of Soft Tissue Healing and Microbiological Status in Patients Undergoing Surgical Extraction of Impacted Mandibular Third Molars Using Cyanoacrylate Adhesive","Inclusion Criteria:\n\n* Patients aged 18 years or older.\n* Patients presenting with bilateral mandibular third molars indicated for extraction, with the same level of surgical difficulty according to the Pell-Gregory classification, and an angulation difference between the two teeth not exceeding 15° according to the Winter classification on panoramic radiographs.\n* No use of local or systemic antibiotics within 2 weeks prior to surgery.\n* Absence of serious systemic diseases such as coagulation disorders or uncontrolled diabetes, and no acute infection at the extraction site.\n* Patients who agree to participate in the study after receiving clear explanation and counseling.\n\nExclusion Criteria:\n\n* Patients who are uncooperative in providing necessary information or who decline to continue participation in the study.\n* A difference in surgical duration between the two sides exceeding 12 minutes, or the occurrence of intraoperative complications.\n* Patients with known hypersensitivity or allergy to any materials used in the study, such as lidocaine local anesthetic, cyanoacrylate adhesive, or suture materials.","ALL","18 Years",{"count":45,"type":46},23,"ESTIMATED","INTERVENTIONAL",[49],"NA","The goal of this randomized clinical trial is to evaluate whether cyanoacrylate tissue adhesive can improve postoperative outcomes compared with conventional silk sutures in patients undergoing surgical removal of impacted mandibular third molars.\n\nThe main questions it aims to answer is: Is there a difference in wound healing support, soft-tissue conditions, and microbiological outcomes at the surgical site of impacted mandibular third molar extraction between closure with conventional sutures and cyanoacrylate tissue adhesive? Researchers will compare cyanoacrylate tissue adhesive with conventional silk sutures to determine whether the adhesive provides superior postoperative recovery and periodontal outcomes.\n\nParticipants will:\n\n* Undergo surgical extraction of an impacted mandibular third molar.\n* Receive wound closure using either cyanoacrylate tissue adhesive or conventional silk sutures.\n* Be followed postoperatively for assessment of pain, swelling, trismus, soft-tissue healing, and periodontal measurements at specified time points.",[52],"Impacted Mandibular Third Molar",[54,55,56,57,58,59,60,61,62,63],"impacted mandibular third molar","Cyanoacrylate tissue adhesive","Silk suture","Wound closure","Postoperative pain","Soft-tissue healing","Periodontal healing","Oral microbiota","Randomized controlled trial","Oral surgery","NOT_YET_RECRUITING","2026-02-25",{"date":67,"type":68},"2026-03-03","ACTUAL",{"date":70,"type":46},"2026-03",{"date":72,"type":46},"2026-12",{"name":5,"class":6}]