[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100054285":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":39,"locations":49,"responsibleParty":69,"collaborators":72,"id":75,"slug":76,"hasResults":77,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":77,"sex":83,"minAge":84,"maxAge":52,"enrollmentInfo":85,"targetDuration":52,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":96,"overallStatus":106,"whyStopped":52,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":116},{"fullName":5,"class":6},"Unity Health Toronto","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Cyanoacrylate Glue + Lipiodol + Coil","ACTIVE_COMPARATOR","Participants randomized to this arm will undergo endoscopic ultrasound-guided treatment of the target gastric varix using coil deployment followed by injection of cyanoacrylate glue mixed with Lipiodol. Repeat coil and\u002For glue injection may be performed at the discretion of the treating endoscopist. Doppler assessment will be performed to assess eradication of flow in the treated gastric varix.",[13],"Procedure: EUS-Guided Coil Embolization With Cyanoacrylate Glue and Lipiodol",{"label":15,"type":16,"description":17,"interventionNames":18},"Absorbable Gelatin Sponge + Coil","EXPERIMENTAL","Participants randomized to this arm will undergo endoscopic ultrasound-guided treatment of the target gastric varix using coil deployment followed by injection of absorbable gelatin sponge slurry. Repeat coil and\u002For absorbable gelatin sponge injection may be performed at the discretion of the treating endoscopist. Doppler assessment will be performed to assess eradication of flow in the treated gastric varix.",[19],"Procedure: EUS-Guided Coil Embolization With Absorbable Gelatin Sponge",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","EUS-Guided Coil Embolization With Cyanoacrylate Glue and Lipiodol","Endoscopic ultrasound-guided treatment of a gastric varix using coil deployment followed by injection of cyanoacrylate glue mixed with Lipiodol under direct visualization. The injection is flushed with sterile water. Repeat coil and\u002For glue injection may be performed at the discretion of the treating endoscopist. Doppler assessment is performed to assess eradication of flow in the treated gastric varix.",[9],[27],"Glue + Lipiodol + Coil; Cyanoacrylate Glue; Glubran2",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"EUS-Guided Coil Embolization With Absorbable Gelatin Sponge","Endoscopic ultrasound-guided treatment of a gastric varix using coil deployment followed by injection of absorbable gelatin sponge slurry under direct visualization. The slurry is flushed with sterile water. Repeat coil and\u002For absorbable gelatin sponge injection may be performed at the discretion of the treating endoscopist. Doppler assessment is performed to assess eradication of flow in the treated gastric varix.",[15],[33],"Gelfoam + Coil; Absorbable Gelatin Sponge; Gelfoam Slurry",[35],{"name":36,"affiliation":37,"role":38},"Sunil Gupta, MD, PhD","Division of Gastroenterology, St. Michael's Hospital, Unity Health Toronto, University of Toronto, Toronto, Ontario, Canada","PRINCIPAL_INVESTIGATOR",[40,46],{"name":41,"role":42,"phone":43,"phoneExt":44,"email":45},"Kareem Khalaf, MD","CONTACT","+1-416-360-4000","77537","kareem.khalaf@unityhealth.to",{"name":47,"role":42,"phone":43,"phoneExt":44,"email":48},"Katina Zheng, MD","Katina.Zheng2@unityhealth.to",[50],{"facility":51,"status":52,"city":53,"state":54,"zip":55,"country":56,"countryCode":57,"cosmosGeoPoint":58,"geoPoint":63,"contacts":64},"St. Michael's Hospital - Unity Health Toronto",null,"Toronto","Ontario","M5B 1W8","Canada","CA",{"type":59,"coordinates":60},"Point",[61,62],-79.39864,43.70643,{"lat":62,"lon":61},[65,66,68],{"name":41,"role":42,"phone":43,"phoneExt":44,"email":45},{"name":47,"role":42,"phone":43,"phoneExt":44,"email":67},"katina.zheng2@unityhealth.to",{"name":36,"role":38,"phone":52,"phoneExt":52,"email":52},{"type":38,"investigatorFullName":70,"investigatorTitle":71,"investigatorAffiliation":5,"oldNameTitle":52,"oldOrganization":52},"Sunil Gupta","Assistant Professor",[73],{"name":74,"class":6},"University of Toronto","100054285","cyanoacrylate-glue-versus-absorbable-gelatin-sponge-for-gastric-varices-100054285",false,"NCT07699354","Cyanoacrylate Glue Versus Absorbable Gelatin Sponge for Gastric Varices","Cyanoacrylate Glue Versus Absorbable Gelatin Sponge for Endoscopic Treatment of Gastric Varices (CoAGS-GV): A Randomized, Patient- and Assessor-Blinded, Non-Inferiority Trial","CoAGS-GV","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Gastric varices deemed suitable for EUS-guided endoscopic treatment.\n* History of suspected gastric variceal bleeding or active gastric variceal bleeding, with treatment intended for secondary prophylaxis.\n* Ability to provide informed consent directly or through a substitute decision maker.\n* Willingness and ability to undergo clinical follow-up, EUS assessment, and CT imaging.\n\nExclusion Criteria:\n\n* Inability or unwillingness to provide informed consent directly or through a substitute decision maker.\n* No gastric varix present, or gastric varix too small or not amenable to combination therapy.\n* Contraindication to therapeutic EUS or endoscopy.\n* Contraindication to any study material used in the assigned treatment arm.\n* Contraindication to contrast-enhanced CT, if not clinically manageable.\n* Inability to complete planned follow-up.\n* Pregnancy.\n* Any clinical situation in which the treating endoscopist determines that randomization would be unsafe or inappropriate.","ALL","18 Years",{"count":86,"type":87},64,"ESTIMATED","INTERVENTIONAL",[90],"NA","This study compares two endoscopic ultrasound-guided treatments for gastric varices, which are enlarged veins in the stomach that can bleed. Both treatments use small coils placed into the varix. One group will receive coils with cyanoacrylate medical glue, and the other group will receive coils with absorbable gelatin sponge.\n\nThe purpose of the study is to determine whether absorbable gelatin sponge with coils is not worse than cyanoacrylate glue with coils for closing off gastric varices, and to compare safety outcomes. Participants will be randomly assigned to one of the two treatment groups. Participants and outcome assessors will not know which treatment was used, but the doctor performing the procedure will know.\n\nAfter the procedure, participants will be followed for up to 12 months. Follow-up may include clinical assessments, questionnaires about health and quality of life, CT imaging shortly after the procedure, and repeat endoscopic ultrasound assessments to evaluate whether the gastric varix has been successfully treated.",[93,94,95],"Gastric Varices Bleeding","Gastric Varices","Portal Hypertension",[97,98,99,100,101,102,103,104,105],"Endoscopic ultrasound","EUS-guided therapy","Portal hypertension","Cyanoacrylate glue","Absorbable gelatin sponge","Gelfoam","Coil embolization","Variceal obliteration","Secondary prophylaxis","NOT_YET_RECRUITING","2026-07-09",{"date":109,"type":110},"2026-07-13","ACTUAL",{"date":112,"type":87},"2026-08-01",{"date":114,"type":87},"2029-08-01",{"name":5,"class":6},1]