[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100562215":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":18,"locations":25,"responsibleParty":45,"collaborators":18,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":18,"eligibilityCriteria":55,"healthyVolunteers":51,"sex":56,"minAge":57,"maxAge":18,"enrollmentInfo":58,"targetDuration":18,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":67,"overallStatus":27,"whyStopped":18,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"Chang Gung University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"SCA training group","EXPERIMENTAL","Long-term training",[13],"Procedure: Cycling Training",{"label":15,"type":16,"description":17,"interventionNames":18},"SCA Control group","NO_INTERVENTION","Control group",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"PROCEDURE","Cycling Training","Cycling combined with priming strategies to enhance motor learning tasks. Each session will last for 15 minutes, conducted three times per week, over a period of two weeks.",[9],[26],{"facility":5,"status":27,"city":28,"state":18,"zip":29,"country":30,"countryCode":31,"cosmosGeoPoint":32,"geoPoint":37,"contacts":38},"RECRUITING","Taoyuan","333","Taiwan","TW",{"type":33,"coordinates":34},"Point",[35,36],121.29696,24.99368,{"lat":36,"lon":35},[39],{"name":40,"role":41,"phone":42,"phoneExt":43,"email":44},"Ya-Ju Chang, PhD","CONTACT","88632118800","5515","yjchang@mail.cgu.edu.tw",{"type":46,"investigatorFullName":47,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"PRINCIPAL_INVESTIGATOR","Ya-Ju Chang","Professor","100562215","cycling-based-priming-coordination-training-for-enhancing-ataxia-recovery-and-brain-plasticity-100562215",false,"NCT06600269","Cycling-Based Priming Coordination Training for Enhancing Ataxia Recovery and Brain Plasticity","The Effect of Cycling Priming Coordination Training on Ataxia and Brain Plasticity","Inclusion Criteria:\n\n\\- Clinical diagnosis of SCA.\n\nExclusion Criteria:\n\n* Musculoskeletal injuries on legs\n* Osteoporosis.\n* Any peripheral or central nervous system injury or disease patients.","ALL","18 Years",{"count":59,"type":60},40,"ESTIMATED","INTERVENTIONAL",[63],"NA","Effective walking and balance require not only lower limb muscle strength but also coordinated movement. For individuals with Spinocerebellar Ataxia (SCA), rehabilitation strategies targeting coordination are essential to improving mobility and reducing the burden on caregivers. However, evidence-based rehabilitation approaches for ataxia remain limited.\n\nRecent studies suggest that improvements in motor learning are often accompanied by changes in cortical excitability. Abnormal cortical excitability in SCA patients may hinder rehabilitation efforts, yet priming strategies-such as exercise or specific stimuli-have been shown to enhance motor learning by modulating cortical excitability. Cycling exercise, in particular, has demonstrated the potential to improve coordination and influence cortical plasticity in individuals with SCA, making it a promising priming strategy for coordination training.\n\nThis clinical trial aims to:\n\n1. Investigate the priming effect and neural mechanisms of acute cycling exercise on coordination training in patients with SCA.\n2. Explore the long-term impact of priming cycling training on cortical plasticity and functional mobility in individuals with SCA.\n\nThis study seeks to provide insights into optimized rehabilitation interventions that could enhance the quality of life and independence for people with SCA.",[66],"Spinocerebellar Ataxias",[68,69,70,71],"Transcranial Magnetic Stimulation (TMS)","Gait","Motor Control","Motor Learning","2024-10-04",{"date":74,"type":75},"2024-10-08","ACTUAL",{"date":72,"type":75},{"date":78,"type":60},"2026-08",{"name":5,"class":6},1]