[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100558145":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":34,"centralContacts":38,"locations":44,"responsibleParty":55,"collaborators":28,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":28,"eligibilityCriteria":63,"healthyVolunteers":64,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":28,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":77,"overallStatus":46,"whyStopped":28,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Masaryk University","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Caffeine 2 mg","ACTIVE_COMPARATOR","To compare exercise performance of 2 or 4 mg of caffeine per kilogram of body weight to placebo within subjects. Subjects will perform one exercise test (10 km cycling time trial).",[13],"Dietary Supplement: Caffeine 2 mg",{"label":15,"type":10,"description":11,"interventionNames":16},"Caffeine 4 mg",[17],"Dietary Supplement: Caffeine 4 mg",{"label":19,"type":20,"description":11,"interventionNames":21},"Placebo","PLACEBO_COMPARATOR",[22],"Dietary Supplement: Caffeine 0 mg",[24,29,31],{"type":25,"name":9,"description":26,"armGroupLabels":27,"otherNames":28},"DIETARY_SUPPLEMENT","To compare exercise performance of 2 or 4 mg of caffeine per kilogram of body weight to placebo within subjects.",[9],null,{"type":25,"name":15,"description":26,"armGroupLabels":30,"otherNames":28},[15],{"type":25,"name":32,"description":26,"armGroupLabels":33,"otherNames":28},"Caffeine 0 mg",[19],[35],{"name":36,"affiliation":5,"role":37},"Lucie Lipková","PRINCIPAL_INVESTIGATOR",[39],{"name":40,"role":41,"phone":42,"phoneExt":28,"email":43},"Dominik Puda","CONTACT","+420724587249","dominik.puda@fsps.muni.cz",[45],{"facility":5,"status":46,"city":47,"state":28,"zip":28,"country":48,"countryCode":28,"cosmosGeoPoint":49,"geoPoint":54,"contacts":28},"RECRUITING","Brno","Czechia",{"type":50,"coordinates":51},"Point",[52,53],16.60796,49.19522,{"lat":53,"lon":52},{"type":56,"investigatorFullName":28,"investigatorTitle":28,"investigatorAffiliation":28,"oldNameTitle":28,"oldOrganization":28},"SPONSOR","100558145","cyp1a2-and-adora2a-genotypes-and-endurance-performance-100558145",false,"NCT06547307","CYP1A2 and ADORA2A Genotypes and Endurance Performance.","Effects of Caffeine, CYP1A2 and ADORA2A Genotypes on Cycling Endurance Performance.","Inclusion Criteria:\n\n* healthy person\n* any training status\n* within age limits\n* without contraindications to perform the test on a bicycle trainer\n* No contraindications to caffeine intake\n\nExclusion Criteria:\n\n* Pregnancy\n* Breast feeding\n* Cardiovascular disease\n* Hypertension\n* Liver disease in the previous two months\n* Taking drugs that can affect liver function\n* Illness in the period of 14 days before the start of the research\n* Use of caffeine during research",true,"ALL","18 Years","35 Years",{"count":69,"type":70},60,"ESTIMATED","INTERVENTIONAL",[73],"NA","The aim of this randomized, double-blind, placebo-controlled experiment will be to assess the potential effect of the selected gene polymorphism (CYP1A2, ADORA2A) on performance after caffeine ingestion.",[76],"Healthy",[78,79,80,81],"endurance","genotype","caffeine","ergogenic effect","2024-08-07",{"date":84,"type":85},"2024-08-09","ACTUAL",{"date":87,"type":70},"2024-08",{"date":89,"type":70},"2025-03",{"name":5,"class":6},1]