[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100502135":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":31,"centralContacts":39,"locations":44,"responsibleParty":62,"collaborators":10,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":68,"acronym":10,"eligibilityCriteria":69,"healthyVolunteers":66,"sex":70,"minAge":71,"maxAge":10,"enrollmentInfo":72,"targetDuration":10,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":10,"overallStatus":47,"whyStopped":10,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"University of Aarhus","OTHER",[8,13,17],{"label":9,"type":6,"description":10,"interventionNames":11},"12 hours ETI pause",null,[12],"Other: 12 hours ETI pause",{"label":14,"type":6,"description":10,"interventionNames":15},"36 hours ETI pause",[16],"Other: 36 hours ETI pause",{"label":18,"type":6,"description":10,"interventionNames":19},"60 hours ETI pause",[20],"Other: 60 hours ETI pause",[22,25,28],{"type":6,"name":9,"description":23,"armGroupLabels":24,"otherNames":10},"Patients with CF are randomly allocated to ETI pause lasting 12 hours.",[9],{"type":6,"name":14,"description":26,"armGroupLabels":27,"otherNames":10},"Patients with CF are randomly allocated to ETI pause lasting either 36 hours.",[14],{"type":6,"name":18,"description":29,"armGroupLabels":30,"otherNames":10},"Patients with CF are randomly allocated to ETI pause lasting either 60 hours.",[18],[32,36],{"name":33,"affiliation":34,"role":35},"Jens G. Leipziger","Department of Biomedicine, Aarhus University, Denmark","PRINCIPAL_INVESTIGATOR",{"name":37,"affiliation":38,"role":35},"Majbritt Jeppesen","Department of Infectious Diseases, Aarhus University Hospital, Denmark",[40],{"name":41,"role":42,"phone":10,"phoneExt":10,"email":43},"Amalie Q. Rousing, BM","CONTACT","arousing@biomed.au.dk",[45],{"facility":46,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Department of Infectious Diseases, Aarhus University Hospital","RECRUITING","Aarhus C","Central Jutland","8000","Denmark","DK",{"type":54,"coordinates":55},"Point",[56,57],10.21231,56.16558,{"lat":57,"lon":56},[60],{"name":61,"role":42,"phone":10,"phoneExt":10,"email":10},"Amalie Rousing",{"type":63,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100502135","cystic-fibrosis-in-the-kidney-monitoring-the-effectiveness-of-elexacaftortezacaftorivacaftor-in-urine-after-a-short-pause-of-therapy-100502135",false,"NCT05818319","Cystic Fibrosis in the Kidney: Monitoring the Effectiveness of Elexacaftor\u002Ftezacaftor\u002Fivacaftor in Urine After a Short Pause of Therapy","Inclusion Criteria:\n\n* Adult (age \\>17 years) CF patients.\n* Normal kidney function estimated by eGFR\\>90.\n* Adults capable of understanding and voluntarily consenting.\n\nExclusion Criteria:\n\n* Critical acute illness.\n* Severe lung disease (ppFEV1\\\u003C40%).\n* Adults not capable of understanding and voluntarily consenting.","ALL","18 Years",{"count":73,"type":74},30,"ESTIMATED","INTERVENTIONAL",[77],"NA","In cystic fibrosis (CF) renal base excretion is impaired, due to mutations in the Cystic Fibrosis Transmembrane Regulator (CFTR) gene, since CFTR function is crucial in regulation of the kidney's HCO3- excretion.\n\nThe investigators suggest that challenged urine HCO3- excretion is a biomarker of CFTR function, which can be used to evaluate the extent of CFTR dysfunction and the possible correcting effects of CFTR modulating therapy.\n\nThis study aims to evaluate changes in challenged urine HCO3- excretion in CF patients, who are currently in treatment with the triple CFTR modulator combination therapy, Elexacaftor\u002Ftezacaftor\u002Fivacaftor (ETI), before, during, and after a short treatment pause.",[80,81],"Cystic Fibrosis (CF)","CFTR Gene Mutation","2025-02-17",{"date":84,"type":85},"2025-02-19","ACTUAL",{"date":87,"type":85},"2023-06-01",{"date":89,"type":74},"2025-12",{"name":5,"class":6},1]