[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100499454":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":29,"centralContacts":36,"locations":46,"responsibleParty":75,"collaborators":77,"id":85,"slug":86,"hasResults":87,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":91,"eligibilityCriteria":92,"healthyVolunteers":87,"sex":93,"minAge":94,"maxAge":95,"enrollmentInfo":96,"targetDuration":29,"studyType":99,"phases":100,"briefSummary":102,"conditions":103,"keywords":105,"overallStatus":62,"whyStopped":29,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":123},{"fullName":5,"class":6},"Hospices Civils de Lyon","OTHER",[8,13,19],{"label":9,"type":6,"description":10,"interventionNames":11},"Low-fat dairy products within a dietary handling for weight loss","3 servings\u002Fday of low-fat dairy products: 1 serving of low-fat cheese, 1 serving of low-fat yogurt and 1 serving of (semi-)skimmed milk.",[12],"Other: Low-fat dairy products",{"label":14,"type":15,"description":16,"interventionNames":17},"Whole-fat dairy products within a dietary handling for weight loss","EXPERIMENTAL","3 servings\u002Fday of whole-fat dairy products: 1 serving of whole cheese, 1 serving of whole yogurt and 1 serving of whole milk.",[18],"Other: Whole-fat dairy products",{"label":20,"type":15,"description":21,"interventionNames":22},"Whole-fat dairy products enriched with milk polar lipids within a dietary handling for weight loss","3 servings\u002Fday of whole-fat dairy products (1 milk, 1 yogurt, 1 cheese) among which 1 serving\u002Fday is enriched with milk polar lipids via butterier.",[23],"Other: Milk polar lipid enriched whole-fat dairy products",[25,30,33],{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":29},"Low-fat dairy products","3-month intervention",[9],null,{"type":6,"name":31,"description":27,"armGroupLabels":32,"otherNames":29},"Whole-fat dairy products",[14],{"type":6,"name":34,"description":27,"armGroupLabels":35,"otherNames":29},"Milk polar lipid enriched whole-fat dairy products",[20],[37,42],{"name":38,"role":39,"phone":40,"phoneExt":29,"email":41},"Emmanuel DISSE, Pr","CONTACT","+33 4 78 86 14 89","emmanuel.disse@chu-lyon.fr",{"name":43,"role":39,"phone":44,"phoneExt":29,"email":45},"MArie-Caroline MICHALSKI, Dr","+33 4 26 23 61 71","marie-caroline.michalski@inrae.fr",[47,60],{"facility":48,"status":49,"city":50,"state":29,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":29},"Centre de Recherche en Nutrition Humaine Rhône-Alpes","ACTIVE_NOT_RECRUITING","Pierre-Bénite","69310","France","FR",{"type":55,"coordinates":56},"Point",[57,58],4.82424,45.70359,{"lat":58,"lon":57},{"facility":61,"status":62,"city":50,"state":29,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":63,"geoPoint":65,"contacts":66},"Centres Hospitalier Lyon Sud, Service d'Endocrinologie-Diabète-Nutrition","RECRUITING",{"type":55,"coordinates":64},[57,58],{"lat":58,"lon":57},[67,68,71,73],{"name":38,"role":39,"phone":40,"phoneExt":29,"email":41},{"name":69,"role":70,"phone":29,"phoneExt":29,"email":29},"SEGRESTIN Bérénice, Dr","SUB_INVESTIGATOR",{"name":72,"role":70,"phone":29,"phoneExt":29,"email":29},"RAJOT Amélie, Dr",{"name":74,"role":70,"phone":29,"phoneExt":29,"email":29},"CAUSSY Cyrielle, Dr",{"type":76,"investigatorFullName":29,"investigatorTitle":29,"investigatorAffiliation":29,"oldNameTitle":29,"oldOrganization":29},"SPONSOR",[78,81,83],{"name":79,"class":80},"Laboratoire de Recherche en Cardiovasculaire, Métabolisme, Diabétologie et Nutrition","UNKNOWN",{"name":82,"class":6},"Centre de Recherche en Nutrition Humaine Rhone-Alpe",{"name":84,"class":6},"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","100499454","dairy-lipids-and-cardiometabolic-risk-100499454",false,"NCT05783466","Dairy Lipids and Cardiometabolic Risk","Bioactive Dairy Lipids to Manage Cardiometabolic Risk in Obesity","DAILICATE","Inclusion Criteria:\n\n* Men and women between 18-70 years\n* Body Mass Index (BMI) between 35 and 60 kg\u002Fm2 inclusive\n* Stable body weight (weight change +\u002F- 5 % for 3 months prior to screening)\n* Consumption of at least 1 serving\u002Fday of dairy products made from cow's milk\n* Informed consent\n\nExclusion Criteria:\n\n* History of bariatric or digestive surgery or disease interfering with main outcomes\n* Drinking more than 3 glasses of alcohol per day (\\>30g\u002Fday)\n* Pregnancy, parturiency or breastfeeding\n* Food allergies or intolerance to dairy products\n* Dietary restriction (vegetarian or lactovegetarian) or high protein diet\n* Use of dietary supplements\n* Treated with lipid lowering drugs (fibrates, statins, anti-PCSK9, ezetimibe, cholestyramine) within the last 6 weeks before study entry\n* Treated with insulin, GLP-1 analogs, acarbose, corticoids, beta-blockers.\n* Medications interfering with intestinal microbiota (beta-lactamines within 3 months before the study or laxatives)\n* Smoking ≥ 5 cigarettes\u002Fday during the past 6 months.","ALL","18 Years","70 Years",{"count":97,"type":98},75,"ESTIMATED","INTERVENTIONAL",[101],"NA","It is a randomized parallel arm intervention study in adults with severe obesity. The objective is to demonstrate that within a dietary handling for weight loss, the daily ingestion during 3 months of whole dairy products enriched with milk polar lipids or whole dairy products decreases to a greater extent fasting plasma apolipoprotein B concentrations than the daily ingestion of low-fat dairy products (control group).\n\nMetabolic parameters will be assessed before and after the 3-month intervention, both at fasting and in postprandial period after the consumption of standardized meals.",[104],"Morbid Obesity",[106,107,108,109,110,111,112,113],"Obesity","Nutrition","Dietary intervention","Weight loss","Metabolism","Dairy","Fat","Milk polar lipids","2025-06-13",{"date":116,"type":117},"2025-06-18","ACTUAL",{"date":119,"type":117},"2023-06-28",{"date":121,"type":98},"2026-10",{"name":5,"class":6},2]