[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100625958":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":22,"locations":31,"responsibleParty":62,"collaborators":64,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":10,"eligibilityCriteria":77,"healthyVolunteers":74,"sex":78,"minAge":79,"maxAge":10,"enrollmentInfo":80,"targetDuration":10,"studyType":83,"phases":10,"briefSummary":84,"conditions":85,"keywords":89,"overallStatus":99,"whyStopped":10,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},{"fullName":5,"class":6},"Instituto Politécnico de Leiria","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Observational HFpEF Cohort",null,"Single observational cohort including all adults with an established diagnosis of heart failure with preserved ejection fraction (LVEF ≥50%) who received care at the Local Health Unit of the Leiria Region (ULS RL) since September 2018.\n\nClinical, biochemical, imaging, functional, and therapeutic information recorded during previous hospitalizations will be extracted for retrospective analysis.\n\nA subset of participants will later be invited to complete a single cardiopulmonary exercise test (CPET) according to the study protocol.\n\nPhenotypes (clusters) will be identified post-hoc using unsupervised machine-learning methods and are not predefined at the time of enrollment.",[13,17,19],{"name":14,"affiliation":15,"role":16},"Rui M Fonseca-Pinto, PhD","ciTechCare - Center for Innovative Care and Health Technology, Polytechnic of Leiria","STUDY_DIRECTOR",{"name":18,"affiliation":15,"role":16},"João C A Morais, PhD",{"name":20,"affiliation":21,"role":16},"Vera L P Geraldes, PhD","Faculty of Medicine, University of Lisbon",[23,28],{"name":24,"role":25,"phone":26,"phoneExt":10,"email":27},"Sónia C Santos, MSc","CONTACT","+351910724415","sonia.c.santos@ipleiria.pt",{"name":14,"role":25,"phone":29,"phoneExt":10,"email":30},"+351965632378","rui.pinto@ipleiria.pt",[32,50],{"facility":33,"status":10,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Local Health Unit of the Leiria Region","Leiria","Leiria District","2410-197","Portugal","PT",{"type":40,"coordinates":41},"Point",[42,43],-8.80705,39.74362,{"lat":43,"lon":42},[46],{"name":47,"role":25,"phone":48,"phoneExt":10,"email":49},"Cristiana Fernandes","+351244817000","cristiana.fernandes@chleiria.min-saude.pt",{"facility":51,"status":10,"city":34,"state":10,"zip":52,"country":37,"countryCode":38,"cosmosGeoPoint":53,"geoPoint":55,"contacts":56},"ciTechCare - Center for Innovative Care and Health Technology","2414-016",{"type":40,"coordinates":54},[42,43],{"lat":43,"lon":42},[57,61],{"name":58,"role":25,"phone":59,"phoneExt":10,"email":60},"Maria P S Guarino, PhD","+351914816037","maria.guarino@ipleiria.pt",{"name":14,"role":25,"phone":29,"phoneExt":10,"email":30},{"type":63,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[65,68,70],{"name":66,"class":67},"Faculty of Medicine of Universidade de Lisboa (FMUL)","UNKNOWN",{"name":69,"class":67},"Hospital Santo André - Centro Hospitalar de Leiria",{"name":71,"class":67},"Fundação para a Ciência e a Tecnologia (FCT)","100625958","data-driven-phenotyping-in-heart-failure-with-preserved-ejection-fraction-100625958",false,"NCT07429396","Data-Driven Phenotyping in Heart Failure With Preserved Ejection Fraction","Inclusion Criteria\n\n1. Retropective observational phase (Phase I):\n\n   * Age ≥18 years;\n   * Established diagnosis of heart failure with preserved ejection fraction (LVEF ≥50%);\n   * Patients receiving care (outpatient or inpatient) at the Local Health Unit of the Leiria Region (ULS RL) since September 2018.\n2. Cross-sectional observational phase (Phase II - CPET):\n\n   * Age ≥18 years;\n   * Established diagnosis of HFpEF;\n   * Selection as a volunteer representative of phenotypes identified in the retrospective clustering analysis;\n   * Provision of written informed consent prior to any study-specific procedures.\n\nExclusion Criteria:\n\n1. Retropective observational phase (Phase I):\n\n   * Incomplete or inadequate medical records preventing full data extraction.\n2. Cross-sectional observational phase (Phase II - CPET):\n\n   * Medical contraindication or physical inability to perform cardiopulmonary exercise testing (CPET);\n   * Inability to provide informed consent.","ALL","18 Years",{"count":81,"type":82},200,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to learn how people with Heart Failure with Preserved Ejection Fraction (HFpEF) can be grouped into different \"phenotypes\" based on their clinical information. The researchers want to understand whether these groups have different health profiles and different responses during a cardiopulmonary exercise test (CPET).\n\nThe main questions this study aims to answer are:\n\n* Can clinical data be used to identify meaningful HFpEF phenotypes?\n* Do these phenotypes match well-known HFpEF scores, such as the H2FPEF and Heart Failure Association Pre-test Assessment, Echocardiography and Natriuretic Peptide (HFA-PEFF) scores?\n* Do people in different phenotypes show different results on a CPET?\n\nParticipants will:\n\n* Have their past clinical records reviewed if they were diagnosed with HFpEF at the Local Health Unit of the Leiria Region (ULS RL);\n* A smaller group will attend one visit to complete a CPET, which measures how the heart, lungs and muscles respond during exercise.\n\nThis study includes adults aged 18 years or older who have HFpEF. The study does not involve any new treatments or experimental drugs.",[86,87,88],"Heart Failure","Heart Failure, Diastolic","Heart Failure With Preserved Ejection Fraction (HFPEF)",[86,90,91,92,93,94,95,96,97,98],"HFpEF","Preserved Ejection Fraction","Phenotyping","Machine Learning","Data-driven clustering","Cardiopulmonary Exercise Testing","H2FPEF score","HFA-PEFF score","Exercise tolerance","NOT_YET_RECRUITING","2026-02-20",{"date":102,"type":103},"2026-02-24","ACTUAL",{"date":105,"type":82},"2026-12-01",{"date":107,"type":82},"2028-05-31",{"name":5,"class":6},2]