[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100512363":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":13,"locations":18,"responsibleParty":326,"collaborators":7,"id":328,"slug":329,"hasResults":330,"nctId":331,"briefTitle":332,"officialTitle":333,"acronym":334,"eligibilityCriteria":335,"healthyVolunteers":330,"sex":336,"minAge":7,"maxAge":7,"enrollmentInfo":337,"targetDuration":7,"studyType":340,"phases":7,"briefSummary":341,"conditions":342,"keywords":7,"overallStatus":66,"whyStopped":7,"lastUpdateSubmitDate":344,"lastUpdatePostDateStruct":345,"startDateStruct":348,"completionDateStruct":350,"leadSponsor":352,"locationsCount":353},{"fullName":5,"class":6},"Institut National de la Santé Et de la Recherche Médicale, France","OTHER_GOV",null,[9],{"name":10,"affiliation":11,"role":12},"Bernard MAITRE","INSERM UMR 955","PRINCIPAL_INVESTIGATOR",[14],{"name":10,"role":15,"phone":16,"phoneExt":7,"email":17},"CONTACT","+33 1 57 02 20 82","bernard.maitre@chicreteil.fr",[19,34,45,56,64,75,82,89,97,108,119,130,141,149,160,168,179,186,197,208,215,223,231,239,247,255,266,277,288,296,307,315],{"facility":20,"status":21,"city":22,"state":7,"zip":7,"country":23,"countryCode":24,"cosmosGeoPoint":25,"geoPoint":30,"contacts":31},"Hôpital Jean Minjoz","NOT_YET_RECRUITING","Besançon","France","FR",{"type":26,"coordinates":27},"Point",[28,29],6.01815,47.24878,{"lat":29,"lon":28},[32],{"name":33,"role":15,"phone":7,"phoneExt":7,"email":7},"Marie-Laure DALPHIN",{"facility":35,"status":21,"city":36,"state":7,"zip":7,"country":23,"countryCode":24,"cosmosGeoPoint":37,"geoPoint":41,"contacts":42},"Hôpital Pellegrin-Enfants","Bordeaux",{"type":26,"coordinates":38},[39,40],-0.58046,44.84124,{"lat":40,"lon":39},[43],{"name":44,"role":15,"phone":7,"phoneExt":7,"email":7},"Michael FAYON",{"facility":46,"status":21,"city":47,"state":7,"zip":7,"country":23,"countryCode":24,"cosmosGeoPoint":48,"geoPoint":52,"contacts":53},"CHU de Caen","Caen",{"type":26,"coordinates":49},[50,51],-0.35912,49.18585,{"lat":51,"lon":50},[54],{"name":55,"role":15,"phone":7,"phoneExt":7,"email":7},"Emmanuel BERGOT",{"facility":57,"status":21,"city":47,"state":7,"zip":7,"country":23,"countryCode":24,"cosmosGeoPoint":58,"geoPoint":60,"contacts":61},"Hôpital Clémenceau",{"type":26,"coordinates":59},[50,51],{"lat":51,"lon":50},[62],{"name":63,"role":15,"phone":7,"phoneExt":7,"email":7},"Jacques BROUARD",{"facility":65,"status":66,"city":67,"state":7,"zip":7,"country":23,"countryCode":24,"cosmosGeoPoint":68,"geoPoint":72,"contacts":73},"Centre Hospitalier Intercommunal de Créteil","RECRUITING","Créteil",{"type":26,"coordinates":69},[70,71],2.46569,48.79266,{"lat":71,"lon":70},[74],{"name":10,"role":15,"phone":7,"phoneExt":7,"email":7},{"facility":65,"status":21,"city":67,"state":7,"zip":7,"country":23,"countryCode":24,"cosmosGeoPoint":76,"geoPoint":78,"contacts":79},{"type":26,"coordinates":77},[70,71],{"lat":71,"lon":70},[80],{"name":81,"role":15,"phone":7,"phoneExt":7,"email":7},"André COSTE",{"facility":65,"status":66,"city":67,"state":7,"zip":7,"country":23,"countryCode":24,"cosmosGeoPoint":83,"geoPoint":85,"contacts":86},{"type":26,"coordinates":84},[70,71],{"lat":71,"lon":70},[87],{"name":88,"role":15,"phone":7,"phoneExt":7,"email":7},"Ralph EPAUD",{"facility":90,"status":66,"city":67,"state":7,"zip":7,"country":23,"countryCode":24,"cosmosGeoPoint":91,"geoPoint":93,"contacts":94},"Hôpital Henri Mondor",{"type":26,"coordinates":92},[70,71],{"lat":71,"lon":70},[95],{"name":96,"role":15,"phone":7,"phoneExt":7,"email":7},"Emilie BEQUIGNON",{"facility":98,"status":21,"city":99,"state":7,"zip":7,"country":23,"countryCode":24,"cosmosGeoPoint":100,"geoPoint":104,"contacts":105},"Hôpital Le Bocage","Dijon",{"type":26,"coordinates":101},[102,103],5.01391,47.31344,{"lat":103,"lon":102},[106],{"name":107,"role":15,"phone":7,"phoneExt":7,"email":7},"Anne HOUZEL",{"facility":109,"status":66,"city":110,"state":7,"zip":7,"country":23,"countryCode":24,"cosmosGeoPoint":111,"geoPoint":115,"contacts":116},"Hôpital Bicêtre","Le Kremlin-Bicêtre",{"type":26,"coordinates":112},[113,114],2.36073,48.81471,{"lat":114,"lon":113},[117],{"name":118,"role":15,"phone":7,"phoneExt":7,"email":7},"Jean-François PAPON",{"facility":120,"status":66,"city":121,"state":7,"zip":7,"country":23,"countryCode":24,"cosmosGeoPoint":122,"geoPoint":126,"contacts":127},"Hôpital Jeanne de Flandre","Lille",{"type":26,"coordinates":123},[124,125],3.05512,50.63391,{"lat":125,"lon":124},[128],{"name":129,"role":15,"phone":7,"phoneExt":7,"email":7},"Caroline THUMERELLE",{"facility":131,"status":66,"city":132,"state":7,"zip":7,"country":23,"countryCode":24,"cosmosGeoPoint":133,"geoPoint":137,"contacts":138},"Hôpital Femme-Mère-Enfant","Lyon",{"type":26,"coordinates":134},[135,136],4.84789,45.74906,{"lat":136,"lon":135},[139],{"name":140,"role":15,"phone":7,"phoneExt":7,"email":7},"Philippe REIX",{"facility":142,"status":66,"city":132,"state":7,"zip":7,"country":23,"countryCode":24,"cosmosGeoPoint":143,"geoPoint":145,"contacts":146},"Hôpital Louis Pradel",{"type":26,"coordinates":144},[135,136],{"lat":136,"lon":135},[147],{"name":148,"role":15,"phone":7,"phoneExt":7,"email":7},"Vincent COTTIN",{"facility":150,"status":21,"city":151,"state":7,"zip":7,"country":23,"countryCode":24,"cosmosGeoPoint":152,"geoPoint":156,"contacts":157},"Hôpital de la Timone","Marseille",{"type":26,"coordinates":153},[154,155],5.38107,43.29695,{"lat":155,"lon":154},[158],{"name":159,"role":15,"phone":7,"phoneExt":7,"email":7},"Jean-Christophe DUBUS",{"facility":161,"status":66,"city":151,"state":7,"zip":7,"country":23,"countryCode":24,"cosmosGeoPoint":162,"geoPoint":164,"contacts":165},"Hôpital Nord",{"type":26,"coordinates":163},[154,155],{"lat":155,"lon":154},[166],{"name":167,"role":15,"phone":7,"phoneExt":7,"email":7},"Martine REYNAUD-GAUBERT",{"facility":169,"status":66,"city":170,"state":7,"zip":7,"country":23,"countryCode":24,"cosmosGeoPoint":171,"geoPoint":175,"contacts":176},"Hôpital Arnaud de Villeneuve","Montpellier",{"type":26,"coordinates":172},[173,174],3.87635,43.61093,{"lat":174,"lon":173},[177],{"name":178,"role":15,"phone":7,"phoneExt":7,"email":7},"Marie-Catherine RENOUX",{"facility":169,"status":21,"city":170,"state":7,"zip":7,"country":23,"countryCode":24,"cosmosGeoPoint":180,"geoPoint":182,"contacts":183},{"type":26,"coordinates":181},[173,174],{"lat":174,"lon":173},[184],{"name":185,"role":15,"phone":7,"phoneExt":7,"email":7},"Raphaël CHIRON",{"facility":187,"status":21,"city":188,"state":7,"zip":7,"country":23,"countryCode":24,"cosmosGeoPoint":189,"geoPoint":193,"contacts":194},"Hôpital Lenval","Nice",{"type":26,"coordinates":190},[191,192],7.26608,43.70313,{"lat":192,"lon":191},[195],{"name":196,"role":15,"phone":7,"phoneExt":7,"email":7},"Marc ALBERTINI",{"facility":198,"status":66,"city":199,"state":7,"zip":7,"country":23,"countryCode":24,"cosmosGeoPoint":200,"geoPoint":204,"contacts":205},"Hôpital Armand Trousseau","Paris",{"type":26,"coordinates":201},[202,203],2.3488,48.85341,{"lat":203,"lon":202},[206],{"name":207,"role":15,"phone":7,"phoneExt":7,"email":7},"Marie LEGENDRE",{"facility":198,"status":66,"city":199,"state":7,"zip":7,"country":23,"countryCode":24,"cosmosGeoPoint":209,"geoPoint":211,"contacts":212},{"type":26,"coordinates":210},[202,203],{"lat":203,"lon":202},[213],{"name":214,"role":15,"phone":7,"phoneExt":7,"email":7},"Guillaume THOUVENIN",{"facility":216,"status":66,"city":199,"state":7,"zip":7,"country":23,"countryCode":24,"cosmosGeoPoint":217,"geoPoint":219,"contacts":220},"Hôpital Bichat",{"type":26,"coordinates":218},[202,203],{"lat":203,"lon":202},[221],{"name":222,"role":15,"phone":7,"phoneExt":7,"email":7},"Camille TAILLE",{"facility":224,"status":66,"city":199,"state":7,"zip":7,"country":23,"countryCode":24,"cosmosGeoPoint":225,"geoPoint":227,"contacts":228},"Hôpital Cochin",{"type":26,"coordinates":226},[202,203],{"lat":203,"lon":202},[229],{"name":230,"role":15,"phone":7,"phoneExt":7,"email":7},"Isabelle HONORE",{"facility":232,"status":66,"city":199,"state":7,"zip":7,"country":23,"countryCode":24,"cosmosGeoPoint":233,"geoPoint":235,"contacts":236},"Hôpital Necker-Enfants Malades",{"type":26,"coordinates":234},[202,203],{"lat":203,"lon":202},[237],{"name":238,"role":15,"phone":7,"phoneExt":7,"email":7},"Rola ABOU TAAM",{"facility":240,"status":21,"city":199,"state":7,"zip":7,"country":23,"countryCode":24,"cosmosGeoPoint":241,"geoPoint":243,"contacts":244},"Hôpital Robert Debré",{"type":26,"coordinates":242},[202,203],{"lat":203,"lon":202},[245],{"name":246,"role":15,"phone":7,"phoneExt":7,"email":7},"Véronique HONDOUIN",{"facility":248,"status":66,"city":199,"state":7,"zip":7,"country":23,"countryCode":24,"cosmosGeoPoint":249,"geoPoint":251,"contacts":252},"Hôpital Tenon",{"type":26,"coordinates":250},[202,203],{"lat":203,"lon":202},[253],{"name":254,"role":15,"phone":7,"phoneExt":7,"email":7},"Jacques CADRANEL",{"facility":256,"status":66,"city":257,"state":7,"zip":7,"country":23,"countryCode":24,"cosmosGeoPoint":258,"geoPoint":262,"contacts":263},"American Memorial Hospital","Reims",{"type":26,"coordinates":259},[260,261],4.02853,49.26526,{"lat":261,"lon":260},[264],{"name":265,"role":15,"phone":7,"phoneExt":7,"email":7},"Katia BESSACI",{"facility":267,"status":21,"city":268,"state":7,"zip":7,"country":23,"countryCode":24,"cosmosGeoPoint":269,"geoPoint":273,"contacts":274},"Hôpital Charles Nicolle","Rouen",{"type":26,"coordinates":270},[271,272],1.09932,49.44313,{"lat":272,"lon":271},[275],{"name":276,"role":15,"phone":7,"phoneExt":7,"email":7},"Laure COUDERC",{"facility":278,"status":66,"city":279,"state":7,"zip":7,"country":23,"countryCode":24,"cosmosGeoPoint":280,"geoPoint":284,"contacts":285},"Hospices Civils","Strasbourg",{"type":26,"coordinates":281},[282,283],7.74553,48.58392,{"lat":283,"lon":282},[286],{"name":287,"role":15,"phone":7,"phoneExt":7,"email":7},"Sandrine HIRSCHI",{"facility":289,"status":21,"city":279,"state":7,"zip":7,"country":23,"countryCode":24,"cosmosGeoPoint":290,"geoPoint":292,"contacts":293},"Hôpital Hautepierre",{"type":26,"coordinates":291},[282,283],{"lat":283,"lon":282},[294],{"name":295,"role":15,"phone":7,"phoneExt":7,"email":7},"Laurence WEISS",{"facility":297,"status":66,"city":298,"state":7,"zip":7,"country":23,"countryCode":24,"cosmosGeoPoint":299,"geoPoint":303,"contacts":304},"Hôpital des Enfants","Toulouse",{"type":26,"coordinates":300},[301,302],1.44367,43.60426,{"lat":302,"lon":301},[305],{"name":306,"role":15,"phone":7,"phoneExt":7,"email":7},"Léa RODITIS",{"facility":308,"status":21,"city":298,"state":7,"zip":7,"country":23,"countryCode":24,"cosmosGeoPoint":309,"geoPoint":311,"contacts":312},"Hôpital Larrey",{"type":26,"coordinates":310},[301,302],{"lat":302,"lon":301},[313],{"name":314,"role":15,"phone":7,"phoneExt":7,"email":7},"Marlène MURRIS-ESPIN",{"facility":316,"status":21,"city":317,"state":7,"zip":7,"country":23,"countryCode":24,"cosmosGeoPoint":318,"geoPoint":322,"contacts":323},"Hôpital de Clocheville","Tours",{"type":26,"coordinates":319},[320,321],0.70398,47.39484,{"lat":321,"lon":320},[324],{"name":325,"role":15,"phone":7,"phoneExt":7,"email":7},"Isabelle GIBERTINI",{"type":327,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100512363","dcp-radico-cohort-radico-dcp-100512363",false,"NCT05951478","DCP (RaDiCo Cohort) (RaDiCo-DCP)","Primary Ciliary Dyskinesias: Identification of Specific Severity Criteria and Phenotype-genotype Correlation Study","DCP","Inclusion Criteria:\n\n* Patient fulfilling at least one of the following criteria for PCD confirmed diagnosis: Kartagener's syndrome and\u002For specific anomaly of the ciliary ultrastructure and\u002For an unambiguous mutation in a PCD gene\n* Having at least one annual follow-up visit\n\nNon-inclusion Criteria:\n\n* Patients with an unconfirmed diagnosis of PCD\n* Patients with an evolving concomitant pathology that may interfere with the assessment of PCD-related manifestations","ALL",{"count":338,"type":339},300,"ESTIMATED","OBSERVATIONAL","Primary Ciliary Dyskinesias (PCD) are rare, autosomal recessive respiratory diseases, due to a defect in mucociliary clearance linked to abnormalities in the structure and\u002For function of the cilia. The variety of ciliary abnormalities identified reflects the genetic heterogeneity of PCDs. The thirty or so genes currently implicated explain the pathology in about half of the patients. PCDs are characterized by recurrent infections of the upper (rhinosinusitis) and lower (bronchitis) airways, beginning in early childhood and progressing respectively to nasal polyposis and bronchial dilatation. In half of the cases, there is a lateralization defect of the organs (situs inversus) corresponding to Kartagener's syndrome. There is more frequent infertility in men (immobility of spermatozoa) than in women (miscarriages and tubal pregnancies). About a third of patients progress to respiratory failure. The identification of predictive factors of severity, specific to PCDs, would improve patient care. It is also important to assess the quality of life of patients with PCD, particularly at the ENT level.\n\nData from prevalent patients are currently integrated into three separate and complementary databases: the \"e-RespiRare\" database, the \"DCP Cils\" database and the \"DCP genes\" database. The first step is therefore to constitute the RaDiCo-DCP database which will include data from prevalent and incident patients whose diagnosis of PCD is certain.\n\nThe cohort aims to improve the routine care of PCD patients, in particular by highlighting predictive factors of severity, allowing early and personalized care, to assess the social impact (quality of life) and medical conditions of ENT impairment, as well as adult infertility, to finely characterize the ciliary phenotype. The study also aims to search for new DCP genes and to allow genotype\u002Fphenotype correlation studies.",[343],"Primary Ciliary Dyskinesia","2026-02-10",{"date":346,"type":347},"2026-02-12","ACTUAL",{"date":349,"type":347},"2017-05-01",{"date":351,"type":339},"2027-05-01",{"name":5,"class":6},32]