[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100587079":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":25,"locations":28,"responsibleParty":49,"collaborators":52,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":25,"eligibilityCriteria":61,"healthyVolunteers":62,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":25,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":75,"overallStatus":31,"whyStopped":25,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"University of Birmingham","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"High-flavonoid grape intervention","EXPERIMENTAL","60 g freeze-dried grape powder, equivalent to 300 g fresh grapes (Total polyphenols: 437 mg\u002F100g)",[13],"Dietary Supplement: High-flavonoid grape intervention",{"label":15,"type":16,"description":17,"interventionNames":18},"Low-flavonoid grape intervention","PLACEBO_COMPARATOR","60 g powder isocaloric-matched control (Total polyphenols: \\\u003C 60 mg)",[19],"Dietary Supplement: Low-flavonoid grape intervention",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DIETARY_SUPPLEMENT","High-flavonoid grape powder: 60 g, equivalent to 300 g fresh grapes. Total polyphenols: 437 mg\u002F100g).",[9],null,{"type":22,"name":15,"description":17,"armGroupLabels":27,"otherNames":25},[15],[29],{"facility":30,"status":31,"city":32,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"School of Sport, Exercise & Rehabilitation Sciences","RECRUITING","Birmingham","West Midlands","B15 2TT","United Kingdom","UK",{"type":38,"coordinates":39},"Point",[40,41],-1.89983,52.48142,{"lat":41,"lon":40},[44],{"name":45,"role":46,"phone":47,"phoneExt":25,"email":48},"Catarina Rendeiro","CONTACT","+44 7389190669","c.rendeiro@bham.ac.uk",{"type":50,"investigatorFullName":45,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Principal Investigator, Assistant Professor in Nutritional Sciences",[53],{"name":54,"class":6},"California Table Grape Commission","100587079","de-stressing-the-brain-can-eating-grapes-during-periods-of-mental-stress-protect-brain-and-vascular-health-in-young-adults-100587079",false,"NCT06923722","De-stressing the Brain: Can Eating Grapes During Periods of Mental Stress Protect Brain and Vascular Health in Young Adults","A Placebo-controlled, Randomized, Double-masked, Cross-over Acute Intervention Study Investigating the Effects of Grape Polyphenols on Cerebral Oxygenation, Cognitive and Vascular Function in the Context of Mental Stress in Young Adults","Inclusion Criteria:\n\n* Males and females\n* 18 - 40 years old\n\nExclusion Criteria:\n\n* Smokers\n* Consumes \\> 21 units of alcohol per week\n* History of cardiovascular, respiratory, metabolic, liver or inflammatory diseases\n* Suffers from blood-clotting disorders\n* Allergies or intolerances to foods\n* On a weight reducing dietary regiment\n* Currently taking dietary supplements, including fatty acids and vitamins\n* On long-term medication or have been on antibiotics in the last 3 months\n* Has an infection at present (e.g. cold) or viral infection",true,"ALL","18 Years","40 Years",{"count":67,"type":68},44,"ESTIMATED","INTERVENTIONAL",[71],"NA","The main aim of the current study is to investigate whether consuming grapes rich in flavonoids just before mental stress can protect cerebrovascular and peripheral vascular function, mood and cognition, from the negative effects of mental stress in young healthy adults. A second, exploratory aim, will further address whether quality of habitual diet, microbiome health (composition; metabolites production e.g. Short-chain fatty acids) and levels of cardiorespiratory fitness play a role on the beneficial effects of grapes during mental stress. All participants will receive a high-flavonoid grape intervention (60 g freeze-dried grape powder, equivalent to 300 g fresh grapes) and a low-flavonoid grape intervention (60 g powdere isocaloric-matched control). It is hypothesized that the high-flavonoid grape intervention will improve cortical oxygenation and cognitive function in the context of mental stress, and prevent the stress-induced decline in peripheral endothelial function following stress. Furthermore, it is hypothesized that individuals with poorer diets, cardiorespiratory fitness and a poorer gut microbiome will benefit more from the grape intervention in the context of mental stress.",[74],"Healthy",[76,77,78,79,80,81,82,83,84],"vascular function","flavonoids","cerebral oxygenation","mental stress","cognition","executive function","grape","Flow-mediated dilatation","Functional Near-Infrared Spectroscopy","2025-12-03",{"date":87,"type":88},"2025-12-04","ACTUAL",{"date":90,"type":88},"2025-04-01",{"date":92,"type":68},"2026-03-31",{"name":5,"class":6},1]