[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100519175":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":25,"centralContacts":29,"locations":34,"responsibleParty":72,"collaborators":75,"id":78,"slug":79,"hasResults":80,"nctId":81,"briefTitle":82,"officialTitle":82,"acronym":24,"eligibilityCriteria":83,"healthyVolunteers":80,"sex":84,"minAge":85,"maxAge":24,"enrollmentInfo":86,"targetDuration":24,"studyType":89,"phases":90,"briefSummary":92,"conditions":93,"keywords":97,"overallStatus":57,"whyStopped":24,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":108},{"fullName":5,"class":6},"Dana-Farber Cancer Institute","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Exercise Group","EXPERIMENTAL","Participants will partake in a 16-week supervised exercise program.",[13],"Behavioral: Supervised Circuit Training",{"label":15,"type":10,"description":16,"interventionNames":17},"Attention Control Group","Participants will continue with their normal daily activities.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"BEHAVIORAL","Supervised Circuit Training","16-week, multicomponent exercise intervention comprised of sessions supervised by certified exercise oncology trainer and home-based, self-directed aerobic exercises. Stationary bike and accelerometer (activity\u002Fheart rate monitor) will be provided.",[15,9],null,[26],{"name":27,"affiliation":5,"role":28},"Christina Dieli-Conwright, MD","PRINCIPAL_INVESTIGATOR",[30],{"name":27,"role":31,"phone":32,"phoneExt":24,"email":33},"CONTACT","617-582-8321","ChristinaM_Dieli-Conwright@dfci.harvard.edu",[35,55,66],{"facility":36,"status":37,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Beth Israel Deaconess Medical Center","NOT_YET_RECRUITING","Boston","Massachusetts","02215","United States","US",{"type":44,"coordinates":45},"Point",[46,47],-71.05977,42.35843,{"lat":47,"lon":46},[50,54],{"name":51,"role":31,"phone":52,"phoneExt":24,"email":53},"David Einstein, MD","617-667-1957","Deinstei@bidmc.harvard.edu",{"name":51,"role":28,"phone":24,"phoneExt":24,"email":24},{"facility":56,"status":57,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":58,"geoPoint":60,"contacts":61},"Brigham and Women's Hospital","RECRUITING",{"type":44,"coordinates":59},[46,47],{"lat":47,"lon":46},[62,65],{"name":63,"role":31,"phone":32,"phoneExt":24,"email":64},"Christina Dieli-Conwright, PhD, MPH","ChristinaM_Dieli-Conwright@DFCI.HARVARD.EDU",{"name":63,"role":28,"phone":24,"phoneExt":24,"email":24},{"facility":5,"status":37,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":67,"geoPoint":69,"contacts":70},{"type":44,"coordinates":68},[46,47],{"lat":47,"lon":46},[71],{"name":27,"role":31,"phone":32,"phoneExt":24,"email":33},{"type":28,"investigatorFullName":73,"investigatorTitle":74,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Christina Dieli-Conwright, PhD","Principle Investigator",[76],{"name":77,"class":6},"Prostate Cancer Foundation","100519175","debunking-the-frailty-sarcopenia-adt-axis-in-metastatic-prostate-cancer-with-multicomponent-exercise-the-fierce-trial-100519175",false,"NCT06040125","Debunking the Frailty-sarcopenIa-ADT Axis in mEtastatic Prostate canceR With multiComponent Exercise: The FIERCE Trial","Inclusion Criteria:\n\n* Ability to understand and the willingness to sign informed consent prior to any study-related procedures.\n* Diagnosed with metastatic prostate cancer.\n* Aged ≥18 years; due to the rarity of the disease in those \\\u003C18 years, this age bracket will not be included.\n* Have been receiving androgen deprivation (either with or without androgen receptor targeted treatment) for at least one month and expect to remain on their treatment for at least 4 months.\n* Are pre-frail or frail as indicated by the FRAIL scale (a score of 1-2 = pre-frail; 3-5 = frail).\n* Have physician's clearance to participate in exercise.\n* Speak English.\n* Participate in less than 2 structured resistance exercise sessions per week over the last 4 months.\n* Participate in less than or equal to 60 minutes of moderate-to-vigorous aerobic exercise per week over the last month.\n* Willing to travel to Dana-Farber Cancer Institute for necessary data collection and exercise sessions.\n\nExclusion Criteria:\n\n* Receiving chemotherapy. This study is exclusively targeting androgen deprivation therapy-related effects.\n* Have unstable bone lesions. In general patients with severely symptomatic\u002Funstable bone lesions due to bone metastases are at a higher risk of fractures.\n* Complete 2 or more structured resistance exercise sessions per week over the last 4 months and participate in more than 60 minutes of moderate-to-vigorous aerobic exercise per week over the last month. Excess additional exercise is a confounding factor in assessing the effect of the current exercise program.\n* Unstable comorbidities that prevent participation in moderate-to-vigorous intensity exercise. Patients with unstable comorbidities likely require supervised exercise for safety, and part of this study involves unsupervised exercise; therefore, for safety reasons, these persons are excluded.\n* Patients receiving treatment for other active malignancies (except basal cell carcinoma). This study is exclusively targeting androgen deprivation therapy-related effects.\n* Subjects who in the opinion of the investigators may not be able to comply with the safety monitoring requirements of the study.","MALE","18 Years",{"count":87,"type":88},80,"ESTIMATED","INTERVENTIONAL",[91],"NA","The purpose of this study is to determine whether a 16-week supervised, clinic-based circuit training intervention utilizing resistance and functional exercises and self-directed aerobic exercise will improve frailty and sarcopenic status and disease progression outcomes among pre-frail\u002Ffrail metastatic prostate cancer patients receiving androgen deprivation therapy (ADT).\n\nThe names of the study intervention involved in this study is:\n\n• Supervised circuit training (aerobic and resistance exercise regimen)",[94,95,96],"PROSTATE CANCER","Metastatic Prostate Cancer","Metastatic Prostate Carcinoma",[98,95,96],"Prostate Cancer","2026-03-10",{"date":101,"type":102},"2026-03-11","ACTUAL",{"date":104,"type":102},"2024-01-01",{"date":106,"type":88},"2027-02-28",{"name":5,"class":6},3]