[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100548829":3},{"organization":4,"armGroups":7,"interventions":30,"overallOfficials":35,"centralContacts":47,"locations":54,"responsibleParty":67,"collaborators":71,"id":76,"slug":77,"hasResults":78,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":84,"sex":85,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":35,"studyType":91,"phases":92,"briefSummary":94,"conditions":95,"keywords":97,"overallStatus":103,"whyStopped":35,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":113},{"fullName":5,"class":6},"Universidad de Almeria","OTHER",[8,14,20,25],{"label":9,"type":10,"description":11,"interventionNames":12},"Thermoneutral condition","PLACEBO_COMPARATOR","n=10; receiving a thermoneutral exposure 2 hours\u002Fday at 32ºC; 5 days\u002Fweek; Total 4 weeks",[13],"Behavioral: Thermoneutral condition",{"label":15,"type":16,"description":17,"interventionNames":18},"Cold condition","EXPERIMENTAL","n=10; receiving 2 hours\u002Fday at 18ºC; 5 days\u002Fweek; Total 4 weeks",[19],"Behavioral: Cold condition",{"label":21,"type":16,"description":22,"interventionNames":23},"Salbutamol","n=10; salbutamol 12 mg\u002Fday. 7 days week. Total 4 weeks",[24],"Drug: Salbutamol",{"label":26,"type":16,"description":27,"interventionNames":28},"Aerobic exercise","n=10; receiving 5 days\u002Fweek at 65% heart rate reserve for 60 minutes each training session. Total 4 weeks",[29],"Behavioral: Aerobic exercise condition",[31,36,39,43],{"type":32,"name":9,"description":33,"armGroupLabels":34,"otherNames":35},"BEHAVIORAL","Participants will be exposed 2 hours\u002Fday at 32ºC for 5 days\u002Fweek",[9],null,{"type":32,"name":15,"description":37,"armGroupLabels":38,"otherNames":35},"Participants will be exposed 2 hours\u002Fday at 18ºC for 5 days\u002Fweek",[15],{"type":32,"name":40,"description":41,"armGroupLabels":42,"otherNames":35},"Aerobic exercise condition","Participants will perform aerobic exercise training 5 days\u002Fweek at 65% heart rate reserve for 60 minutes each training session",[26],{"type":44,"name":21,"description":45,"armGroupLabels":46,"otherNames":35},"DRUG","Participants will take salbutamol 12 mg\u002Fday. 7 days week",[21],[48],{"name":49,"role":50,"phone":51,"phoneExt":52,"email":53},"Borja Martinez Tellez, PhD","CONTACT","+34 950215334","+34","borjammt@ual.es",[55],{"facility":56,"status":35,"city":57,"state":35,"zip":58,"country":59,"countryCode":60,"cosmosGeoPoint":61,"geoPoint":66,"contacts":35},"Universidad de Almería","Almería","04131","Spain","ES",{"type":62,"coordinates":63},"Point",[64,65],-2.45974,36.83814,{"lat":65,"lon":64},{"type":68,"investigatorFullName":69,"investigatorTitle":70,"investigatorAffiliation":5,"oldNameTitle":35,"oldOrganization":35},"PRINCIPAL_INVESTIGATOR","Borja Martínez Tellez","Principal Investigator",[72,74],{"name":73,"class":6},"Leiden University Medical Center",{"name":75,"class":6},"ETH Zurich (Switzerland)","100548829","deciphering-a-novel-and-unique-brown-adipose-tissue-depot-in-women-100548829",false,"NCT06426082","Deciphering a Novel and Unique Brown Adipose Tissue Depot in Women","Deciphering the Molecular and Secretory Functions of a Novel and Unique Brown Adipose Tissue Depot in Women","DEBATE","Inclusion Criteria:\n\n* 18-22 years of age women.\n* BMI between ≥18 and \\\u003C25 kg\u002Fm2\n* Are willing to be randomized to either of these 4 groups.\n* Must be sedentary (i.e., do not perform exercise or go to the gym).\n* Participants should have regular menstrual cycles.\n* Must be willing to adhere to all study procedures, including attendance at all study visits.\n* Must be willing to have biological samples stored for future research.\n* Must accept the use of the Period Calendar and Google Fit Apps on their mobile phones.\n\nExclusion Criteria:\n\n* Diabetes mellitus (determined based on fasting glucose levels defined by ADA criteria).\n* Any other active endocrine disease (thyroid disease, any signs of Cushing's syndrome, adrenal disease and lipid-associated disorders such as familial hypercholesterolemia).\n* Any cardiac disease (i.e., ischemic cardiac disease, arrhythmias, severe heart failure).\n* Use of medication known to influence glucose and\u002For lipid metabolism or brown fat activity (e.g., beta-blockers, antidepressants, corticosteroids).\n* Use of medication shown to increase risk of hypokalemia after salbutamol administration (e.g., xanthine derivatives, steroids and diuretics).\n* Clinically relevant abnormalities in clinical chemistry or electrocardiogram (ECG) at screening (to be judged by the study physician).\n* A first-degree family member with sudden cardiac death.\n* Any chronic renal or hepatic disease.\n* Any other contra-indications for the use of salbutamol or propranolol.\n* Abuse of alcohol or other substances.\n* Smoking.\n* Current participation in another research projects that may influence the current research project.\n* Use of beta-adrenergic receptor agonists (e.g., asthma).\n* Polycystic ovary syndrome.\n* Diagnosed psychotic conditions.",true,"FEMALE","18 Years","22 Years",{"count":89,"type":90},40,"ESTIMATED","INTERVENTIONAL",[93],"NA","Type of Study: Clinical Trial\n\nGoal: The goal of this clinical trial is to investigate specific brown and beige fat cells in the dorsocervical area of young, lean adult women.\n\nParticipant Population\u002FHealth Conditions: The study will involve 40 young, lean adult women.\n\nMain Questions: The main questions this study aims to answer are:\n\n* Are there active brown or beige adipocytes in the subcutaneous fat of the dorsocervical area (i.e., iBAT)?\n* What is the secretory function of these adipocytes?\n* How do traditional interventions like cold exposure, as well as new approaches like Beta-2 agonist stimulation and exercise, affect the thermogenesis of these fat cells at the cellular and molecular levels?\n\nParticipants Will:\n\nBe randomized into one of four groups: thermoneutral exposure, cold exposure, aerobic exercise, or Beta-2 agonist treatment.\n\nFollow their assigned regimen for 4 weeks. Provide tissue samples from the dorsocervical area and abdomen before and after the 4-week intervention.\n\nUndergo analysis of these samples using advanced techniques to understand the presence and activity of brown and beige fat cells.\n\nComparison Group: Researchers will compare the effects of different interventions (thermoneutral exposure, cold exposure, aerobic exercise, Beta-2 agonist treatment) on the presence and thermogenesis of brown and beige fat cells in the dorsocervical area.",[96],"Cardiometabolic Diseases",[98,99,100,101,102],"brown adipose tissue","cold exposure","hot exposure","dorsocervical fat","exercise","NOT_YET_RECRUITING","2024-05-20",{"date":106,"type":107},"2024-05-23","ACTUAL",{"date":109,"type":90},"2024-11-01",{"date":111,"type":90},"2026-08",{"name":5,"class":6},1]