[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100632073":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":12,"locations":22,"responsibleParty":36,"collaborators":10,"id":40,"slug":41,"hasResults":42,"nctId":43,"briefTitle":44,"officialTitle":44,"acronym":45,"eligibilityCriteria":46,"healthyVolunteers":42,"sex":47,"minAge":10,"maxAge":10,"enrollmentInfo":48,"targetDuration":10,"studyType":51,"phases":10,"briefSummary":52,"conditions":53,"keywords":55,"overallStatus":60,"whyStopped":10,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":70},{"fullName":5,"class":6},"Sir Run Run Shaw Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"AECOPD group",null,"Hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) identified from historical hospital records who received routine clinical evaluation and management . The cohort includes patients who received one or more respiratory support modalities as part of usual care, including conventional oxygen therapy, high-flow nasal cannula oxygen therapy, noninvasive ventilation, and invasive mechanical ventilation. This is an observational study, and no intervention is assigned by the protocol.",[13,18],{"name":14,"role":15,"phone":16,"phoneExt":10,"email":17},"Huiqing Ge, PhD","CONTACT","+86 13588706787","gehq@zju.edu.cn",{"name":19,"role":15,"phone":20,"phoneExt":10,"email":21},"Mengyun Zhou, MS","+86 13391882759","3325184@zju.edu.cn",[23],{"facility":24,"status":10,"city":25,"state":26,"zip":27,"country":28,"countryCode":29,"cosmosGeoPoint":30,"geoPoint":35,"contacts":10},"Sir Run Run Shaw Hospital Zhejiang University School of Medicine","Hangzhou","Zhejiang","310016","China","CN",{"type":31,"coordinates":32},"Point",[33,34],120.16142,30.29365,{"lat":34,"lon":33},{"type":37,"investigatorFullName":38,"investigatorTitle":39,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Huiqing Ge","Principal Investigator","100632073","decision-making-and-optimization-of-ventilatory-support-for-aecopd-patients-100632073",false,"NCT07508943","Decision-making and Optimization of Ventilatory Support for AECOPD Patients","OPTIVENT-COPD","Inclusion Criteria:\n\n* Hospitalized patients with a documented diagnosis of acute exacerbation of chronic obstructive pulmonary disease.\n* Patients identified retrospectively from hospital records during the predefined study period.\n* Patients who received at least one form of respiratory support during the index hospitalization, including conventional oxygen therapy, high-flow nasal cannula oxygen therapy, noninvasive ventilation, or invasive mechanical ventilation.\n* Patients with available clinical records containing sufficient dynamic physiological, laboratory, and treatment-related data for retrospective analysis.\n\nExclusion Criteria:\n\n• Patients whose hospitalization was not primarily due to acute exacerbation of COPD, even if COPD was documented as a comorbidity.\n\nPatients with stable COPD and no evidence of acute exacerbation during the index hospitalization.\n\n* Patients admitted primarily for other acute conditions, including but not limited to pneumonia without documented AECOPD, acute heart failure, pulmonary embolism, pneumothorax, asthma exacerbation, trauma, or postoperative care.\n* Patients with insufficient documentation to confirm AECOPD as the primary reason for admission.\n* Patients with incomplete clinical records preventing retrospective analysis.\n* Repeated hospitalizations of the same patient during the study period, with only the first eligible admission included.","ALL",{"count":49,"type":50},1000,"ESTIMATED","OBSERVATIONAL","The goal of this retrospective observational study is to learn about how respiratory support is selected and adjusted in hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). The main questions it aims to answer are:\n\n1. How are different respiratory support modalities selected for patients with AECOPD in real-world practice?\n2. What clinical patterns are associated with escalation, de-escalation, switching, or discontinuation of respiratory support during hospitalization? Researchers will review de-identified hospital records of patients admitted with AECOPD and analyze the dynamic use of respiratory support during hospitalization, including conventional oxygen therapy, high-flow nasal cannula oxygen therapy, non-invasive ventilation, and invasive mechanical ventilation.\n\nParticipants will not receive any study-assigned intervention. The study will use existing clinical data collected during routine inpatient care and will not change diagnosis, treatment, or follow-up.",[54],"Acute Exacerbation of Chronic Obstructive Pulmonary Disease",[54,56,57,58,59],"Decision-Making","Real-World Data","Dynamic Programming","Respiratory Support","NOT_YET_RECRUITING","2026-03-27",{"date":63,"type":64},"2026-04-02","ACTUAL",{"date":66,"type":50},"2026-03-18",{"date":68,"type":50},"2029-03-18",{"name":5,"class":6},1]