[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100622706":3},{"organization":4,"armGroups":7,"interventions":33,"overallOfficials":52,"centralContacts":57,"locations":66,"responsibleParty":83,"collaborators":39,"id":85,"slug":86,"hasResults":87,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":91,"eligibilityCriteria":92,"healthyVolunteers":93,"sex":94,"minAge":95,"maxAge":39,"enrollmentInfo":96,"targetDuration":39,"studyType":99,"phases":100,"briefSummary":102,"conditions":103,"keywords":108,"overallStatus":69,"whyStopped":39,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":123},{"fullName":5,"class":6},"Heart and Brain Research Group, Germany","OTHER",[8,15,19,23,28],{"label":9,"type":10,"description":11,"interventionNames":12},"VR + Binaural Beats","EXPERIMENTAL","Participants receive a virtual reality-based natural environment combined with binaural auditory stimulation for approximately 30 minutes.",[13,14],"Behavioral: Virtual Reality-Based Natural Environment","Behavioral: Binaural Auditory Stimulation",{"label":16,"type":10,"description":17,"interventionNames":18},"VR Only","Participants receive a virtual reality-based natural environment without binaural auditory stimulation for approximately 30 minutes.",[13],{"label":20,"type":10,"description":21,"interventionNames":22},"Audio + Binaural Beats","Participants receive natural soundscapes combined with binaural auditory stimulation without exposure to virtual reality for approximately 30 minutes.",[14],{"label":24,"type":10,"description":25,"interventionNames":26},"Audio Only","Participants receive natural soundscapes without binaural auditory stimulation and without virtual reality exposure for approximately 30 minutes.",[27],"Behavioral: Auditory Stimulation",{"label":29,"type":10,"description":30,"interventionNames":31},"Control","Participants complete standardized control activities without any relaxation intervention for approximately 30 minutes.",[32],"Behavioral: Control Condition (No Relaxation Intervention)",[34,40,44,48],{"type":35,"name":36,"description":37,"armGroupLabels":38,"otherNames":39},"BEHAVIORAL","Virtual Reality-Based Natural Environment","Participants are exposed to immersive virtual reality-based natural landscapes using a head-mounted display for approximately 30 minutes. The content consists of non-animated 360° natural environments",[9,16],null,{"type":35,"name":41,"description":42,"armGroupLabels":43,"otherNames":39},"Binaural Auditory Stimulation","Participants receive auditory stimulation via headphones consisting of natural soundscapes combined with binaural beats. The binaural beat frequency is gradually reduced from the alpha range (10 Hz) to the delta range (1 Hz) over approximately 30 minutes.",[20,9],{"type":35,"name":45,"description":46,"armGroupLabels":47,"otherNames":39},"Control Condition (No Relaxation Intervention)","Participants complete standardized control tasks without exposure to any relaxation intervention.",[29],{"type":35,"name":49,"description":50,"armGroupLabels":51,"otherNames":39},"Auditory Stimulation","Participants receive auditory stimulation via headphones consisting of natural soundscapes over approximately 30 minutes.",[24],[53],{"name":54,"affiliation":55,"role":56},"Marius Butz, PhD, M.Sc.","Heart&Brain Research Group, Kerckhoff-Clinic, Bad Nauheim, Germany","PRINCIPAL_INVESTIGATOR",[58,62],{"name":54,"role":59,"phone":60,"phoneExt":39,"email":61},"CONTACT","Tel.: +49(0)6032\u002F996 5812","m.butz@kerckhoff-klinik.de",{"name":63,"role":59,"phone":64,"phoneExt":39,"email":65},"Rolf Meyer, M.Sc.","Tel.: +49(0)6032\u002F996 2557","r.meyer@kerckhoff-klinik.de",[67],{"facility":68,"status":69,"city":70,"state":39,"zip":71,"country":72,"countryCode":73,"cosmosGeoPoint":74,"geoPoint":79,"contacts":80},"Kerckhoff-Clinic","RECRUITING","Bad Nauheim","61231","Germany","DE",{"type":75,"coordinates":76},"Point",[77,78],8.73859,50.36463,{"lat":78,"lon":77},[81],{"name":54,"role":59,"phone":82,"phoneExt":39,"email":61},"+49(0)6032\u002F996 5812",{"type":56,"investigatorFullName":54,"investigatorTitle":84,"investigatorAffiliation":5,"oldNameTitle":39,"oldOrganization":39},"Principal Investigator","100622706","decreasing-stress-via-virtual-reality-and-binaural-beats-in-non-clinical-adults-100622706",false,"NCT07387107","Decreasing Stress Via Virtual Reality and Binaural Beats in Non-Clinical Adults","Decreasing Stress Via Virtual Reality and Binaural Beats in Non-Clinical Adults: A Randomized Controlled Study.","DESTUD","Inclusion Criteria:\n\n1\\. Adults aged 18 years or older 2. Ability to understand study procedures and provide written informed consent 3. Sufficient proficiency in the German language to complete questionnaires and follow study instructions 4. Willingness to participate in a single approximately 60-minute study session\n\nExclusion Criteria:\n\n1\\. Current or history of neurological or psychiatric disorders that may interfere with data collection (e.g., dementia, major depressive disorder, stroke, epilepsy) 2. Severe visual or hearing impairments that would limit the use of virtual reality equipment or headphones 3. History of adverse reactions to virtual reality",true,"ALL","18 Years",{"count":97,"type":98},52,"ESTIMATED","INTERVENTIONAL",[101],"NA","This study is a non-clinical substudy conducted within the DESTRESS research program (NCT05036538), which investigates the effects of relaxation interventions on physiological and psychological parameters. While the main DESTRESS trial focuses on cardiac surgical patients, this additional study arm examines the same interventions in a non-clinical adult population under controlled conditions, independent of disease-, surgery-, or medication-related influences.\n\nParticipants are randomly assigned to one of several experimental conditions and take part in a single approximately 30-minute session. Depending on group allocation, the session may include exposure to natural soundscapes, natural soundscapes combined with binaural beats, virtual reality-based natural environments, virtual reality combined with binaural beats, or a control condition without a relaxation intervention.\n\nThe primary aim of the DESTUD-Study is to assess the feasibility and potential stress-reducing effects of these non-pharmacological relaxation approaches in a non-clinical setting and to support the interpretation of findings from the clinical DESTRESS trial. Physiological responses, including heart rate variability and electrodermal activity, as well as self-reported stress measures, are collected before, during and after the conditions.",[104,105,106,107],"Stress","Relaxation","Virtual Reality","Binaural Beats",[106,107,109,110,111,112,113],"Heart Rate Variability","Stress Reduction","Relaxation Intervention","Non-Clinical Population","Electrodermal Activity","2026-03-11",{"date":116,"type":117},"2026-03-13","ACTUAL",{"date":119,"type":117},"2026-03-05",{"date":121,"type":98},"2026-07-15",{"name":5,"class":6},1]