[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100450791":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":26,"locations":31,"responsibleParty":59,"collaborators":62,"id":73,"slug":74,"hasResults":75,"nctId":76,"briefTitle":77,"officialTitle":77,"acronym":20,"eligibilityCriteria":78,"healthyVolunteers":75,"sex":79,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":20,"studyType":85,"phases":86,"briefSummary":88,"conditions":89,"keywords":20,"overallStatus":34,"whyStopped":20,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"Massachusetts Eye and Ear Infirmary","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Electrophysiological signal data collection","EXPERIMENTAL","Patients diagnosed with dystonia or tremor who are recommended for DBS surgery. Electrophysiological data will be collected at the time of DBS surgery.",[13],"Procedure: Deep Brain Stimulation",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"PROCEDURE","Deep Brain Stimulation","Clinically indicated DBS treatment for dystonia or tremor with simultaneous research electrocorticography (ECoG).",[9],null,[22],{"name":23,"affiliation":24,"role":25},"Kristina Simonyan, MD, PhD","Massachusetts Eye and Ear","STUDY_DIRECTOR",[27],{"name":23,"role":28,"phone":29,"phoneExt":20,"email":30},"CONTACT","617-573-6016","simonyan_lab@meei.harvard.edu",[32],{"facility":33,"status":34,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"Massachusetts General Hospital, University of California San Francisco, University of Utah","RECRUITING","Boston","Massachusetts","02114","United States","US",{"type":41,"coordinates":42},"Point",[43,44],-71.05977,42.35843,{"lat":44,"lon":43},[47,48,51,53,55,57],{"name":23,"role":28,"phone":29,"phoneExt":20,"email":30},{"name":49,"role":50,"phone":20,"phoneExt":20,"email":20},"Julie Barkmeier-Kraemer, PhD","PRINCIPAL_INVESTIGATOR",{"name":52,"role":50,"phone":20,"phoneExt":20,"email":20},"Ian Bledsoe, MD, MS",{"name":54,"role":50,"phone":20,"phoneExt":20,"email":20},"Shervin Rahimpour, MD",{"name":56,"role":50,"phone":20,"phoneExt":20,"email":20},"Jeremy Greenlee, MD",{"name":58,"role":50,"phone":20,"phoneExt":20,"email":20},"Farid Hamzei-Sichani, MD, PhD",{"type":50,"investigatorFullName":60,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"Kristina Simonyan","Professor of Otolaryngology - Head and Neck Surgery",[63,65,67,69,71],{"name":64,"class":6},"Massachusetts General Hospital",{"name":66,"class":6},"University of Utah",{"name":68,"class":6},"University of California, San Francisco",{"name":70,"class":6},"UMass Memorial Health",{"name":72,"class":6},"University of Iowa","100450791","deep-brain-stimulation-in-laryngeal-dystonia-and-voice-tremor-100450791",false,"NCT05150093","Deep Brain Stimulation in Laryngeal Dystonia and Voice Tremor","Inclusion\n\n1. Clinical indications to proceed with DBS implantation, as determined by the clinical multidisciplinary movement disorders board, including: a) definitive diagnosis of essential tremor or dystonia, b) medically refractory disease, c) adequate performance on neuropsychological evaluation as determined by a licensed clinical neuropsychologist.\n2. The ability to comply with test directions, complete pre-operative task training, and provide informed consent.\n3. Age 18-80 years.\n\nExclusion\n\n1\\. Inability to understand or perform the task outlined in the protocol during a pre-surgery training session. 2. Significant hearing loss.\n\n3\\. Cortical venous anatomy that could potentially obstruct ECoG electrode placement, as determined by the surgeon, visualized on pre-op MRI or during surgery.","ALL","18 Years","80 Years",{"count":83,"type":84},120,"ESTIMATED","INTERVENTIONAL",[87],"NA","The goals of this project are 1) to determine the incidence of neurological voice disorders in patients with dystonia and essential tremor undergoing deep brain stimulation (DBS), 2) investigate the neuroimaging and intracranial neurophysiology correlates of voice dysfunction in these subjects, and subsequently 3) determine the effects of DBS on voice function.",[90,91,92,93],"Laryngeal Dystonia","Spasmodic Dysphonia","Tremor","Dystonia","2025-11-24",{"date":96,"type":97},"2025-12-02","ACTUAL",{"date":99,"type":97},"2022-06-21",{"date":101,"type":84},"2027-08-31",{"name":5,"class":6},1]