[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100630272":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":35,"locations":41,"responsibleParty":51,"collaborators":25,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":25,"eligibilityCriteria":60,"healthyVolunteers":56,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":25,"studyType":67,"phases":68,"briefSummary":70,"conditions":71,"keywords":77,"overallStatus":81,"whyStopped":25,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Menoufia University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"MNMB","ACTIVE_COMPARATOR","rocuronium will be given as 0.2 mg\u002Fkg to maintain a post-tetanic count (PTC) of \\>1, and TOF in the range of",[13],"Drug: Moderate Neuromuscular Blockade",{"label":15,"type":10,"description":16,"interventionNames":17},"DNMB","rocuronium infusion was used to provide 0.48-0.72 mg\u002Fkg\u002Fh to maintain PTC 0-1",[18],"Drug: Deep neuromuscular block",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Moderate Neuromuscular Blockade","A TOF-Watch® SX-acceleromyograph will be applied to the adductor pollicis muscle and calibrated to monitor response and degree of NMB. Anesthesia will be induced with IV propofol (1.5-2.5 mg\u002Fkg) and rocuronium bromide 0.6 mg\u002FKg, and the trachea will be intubated at train-of-four (TOF) 0. Anesthesia will be maintained with 50% air in oxygen and an end-tidal concentration of 2-3% sevoflurane. In the DNMB group, rocuronium infusion was used to provide 0.48-0.72 mg\u002Fkg\u002Fh to maintain PTC 0-1.",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Deep neuromuscular block","For patients in the MNMB group, rocuronium will be given as 0.2 mg\u002Fkg to maintain a post-tetanic count (PTC) of \\>1, and TOF in the range of 0-2.",[15],[31],{"name":32,"affiliation":33,"role":34},"Rabab M Habeeb","Faculty of Medicine Menoufia University","PRINCIPAL_INVESTIGATOR",[36],{"name":37,"role":38,"phone":39,"phoneExt":25,"email":40},"Rabab Habeeb, MD","CONTACT","+201001970973","rabab_habeeb@med.menofia.edu.eg",[42],{"facility":33,"status":25,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":25,"geoPoint":25,"contacts":48},"Menoufia","Eg.mn","32511","Egypt","EG",[49],{"name":37,"role":38,"phone":50,"phoneExt":25,"email":40},"01001970973",{"type":34,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"rabab Mohammad habeeb","Principle investigator","100630272","deep-versus-moderate-neuromuscular-blocking-100630272",false,"NCT07485517","Deep Versus Moderate Neuromuscular Blocking","The Effect of Deep Versus Moderate Neuromuscular Blocking on Patients Undergoing Open Hysterectomy","Inclusion Criteria:\n\n* Women who will be admitted to undergo elective hysterectomy\n\n  ,-ASA grade I or II,\n* Body mass index (BMI) of \\\u003C35 kg\u002Fm2\n\nExclusion Criteria:\n\nhemoglobin concentration of ≤7 gm%,\n\n* the presence of neuromuscular disorders\n* uncontrolled medical diseases\n* autoimmune diseases, maintenance on immunosuppressant therapy for any indication\n* refusal to sign the written consent","FEMALE","18 Years","60 Years",{"count":65,"type":66},88,"ESTIMATED","INTERVENTIONAL",[69],"NA","This study aimed for Determination of the impacts of deep neuromuscular blockade (DNMB) on surgical outcomes, consumption of perioperative opioid analgesia, and serum levels of inflammatory cytokines in comparison to moderate NMB (MNMB).",[72,73,74,75,76],"Change in Serum Levels of the Estimated Inflammatory Cytokines","Total Dose of IO Fentanyl","PO Morphine","Surgeons' Rating","Pain Scores",[78,79,80],"Neuromuscular Blocking","Hysterectomy","cytokines","NOT_YET_RECRUITING","2026-05-29",{"date":84,"type":85},"2026-06-02","ACTUAL",{"date":87,"type":66},"2026-06-01",{"date":89,"type":66},"2026-12-30",{"name":5,"class":6},1]