[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100492054":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":17,"locations":26,"responsibleParty":45,"collaborators":10,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":10,"eligibilityCriteria":52,"healthyVolunteers":49,"sex":53,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":10,"studyType":59,"phases":10,"briefSummary":60,"conditions":61,"keywords":64,"overallStatus":29,"whyStopped":10,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":78},{"fullName":5,"class":6},"National Institutes of Health Clinical Center (CC)","NIH",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Fanconi anemia",null,"A prospective cohort of individuals with Fanconi anemia (FA) at very high risk of squamous cell carcinoma (SCC)",[13],{"name":14,"affiliation":15,"role":16},"Lisa J McReynolds, M.D.","National Cancer Institute (NCI)","PRINCIPAL_INVESTIGATOR",[18,23],{"name":19,"role":20,"phone":21,"phoneExt":10,"email":22},"NCI Family Study Referrals","CONTACT","(800) 518-8474","ncifamilystudyreferrals@mail.nih.gov",{"name":14,"role":20,"phone":24,"phoneExt":10,"email":25},"(240) 276-5047","mcreynoldslj@mail.nih.gov",[27],{"facility":28,"status":29,"city":30,"state":31,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"National Institutes of Health Clinical Center","RECRUITING","Bethesda","Maryland","20892","United States","US",{"type":36,"coordinates":37},"Point",[38,39],-77.10026,38.98067,{"lat":39,"lon":38},[42],{"name":43,"role":20,"phone":44,"phoneExt":10,"email":10},"For more information at the NIH Clinical Center contact National Cancer Institute Referral Office","888-624-1937",{"type":46,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100492054","defining-the-natural-history-of-squamous-cell-carcinoma-in-fanconi-anemia-100492054",false,"NCT05687149","Defining the Natural History of Squamous Cell Carcinoma in Fanconi Anemia","* INCLUSION CRITERIA:\n\n  1. On referral, persons \\>= 12 years with FA primarily from North America will be included. An individual with FA who is 8 - 11 years can also be included if they have a history of persistent OPMLs, dysphagia, or other concerning symptoms.\n  2. Individuals with prior cancer diagnosis are eligible.\n  3. Individuals from other countries are eligible provided they can travel to the USA on their own.\n  4. Ability to understand and\u002For the willingness of the individual, parent, LAR, or minor s legal guardian to provide informed consent.\n\nEXCLUSION CRITERIA:\n\n1. Referred individuals for whom reported diagnosis of FA cannot be verified.\n2. Inability of the individual, parent, LAR, or legal guardian to understand and be willing to sign a written informed consent document.","ALL","8 Years","90 Years",{"count":57,"type":58},200,"ESTIMATED","OBSERVATIONAL","Background:\n\nFanconi anemia (FA) is an inherited disorder. People with FA are more likely to get certain cancers, especially squamous cell carcinoma (SCC). These cancers usually appear first in the mouth, esophagus, and genital and anal areas. Early detection of SCCs may help improve survival rates for people with FA.\n\nObjective:\n\nThis natural history study will regularly screen people with FA for SCC.\n\nEligibility:\n\nPeople aged 12 years and older with FA or a prior cancer diagnosis. Children aged 8 to 11 years with FA may also be eligible.\n\nDesign:\n\nParticipants will receive a comprehensive screening for cancer or early signs of cancer.\n\nParticipants will have a physical exam. They will provide blood and saliva samples. Cells will be collected by rubbing a swab on the inside of the cheeks. A skin sample may be removed from the back, buttocks, or inside of the upper arm.\n\nParticipants will have pictures taken of their mouth. Any mouth sores will be mapped. Cells will be collected from the sores with a small brush.\n\nSpecialists will examine the participant s ears, nose, throat, teeth, and skin.\n\nAdult participants may have a gastrointestinal exam or pelvic exam. Participants may have an endoscopy. A long tube with a camera and a light will be inserted through the mouth and down into the stomach.\n\nParticipants may have a liver ultrasound. A wand will be pressed against their belly to get pictures of the organs inside the body.\n\nParticipants will have screenings every year for up to 10 years. Each visit will last up to 3 days. They will have remote follow-up visits every 6 - 8 months....",[62,63],"Fanconi Anemia","Inherited Bone Marrow Failure Syndrome",[65,63,66,67,68],"Hereditary","Oral Potentially Malignant Lesion","Surveillance","Precancer","2026-06-11",{"date":71,"type":72},"2026-06-12","ACTUAL",{"date":74,"type":72},"2023-03-23",{"date":76,"type":58},"2035-12-31",{"name":15,"class":6},1]