[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100600293":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":26,"centralContacts":31,"locations":41,"responsibleParty":58,"collaborators":60,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":68,"acronym":25,"eligibilityCriteria":69,"healthyVolunteers":70,"sex":71,"minAge":72,"maxAge":25,"enrollmentInfo":73,"targetDuration":25,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":25,"overallStatus":43,"whyStopped":25,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"New York University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Oral Cancer Subjects","EXPERIMENTAL","Oral cancer patients will be tested for pressure and stretch sensitivity. Pressure sensitivity will be evaluated with a digital pressure algometer by applying the probe tip to the site of cancer in oral cancer patients.\n\nStretch sensitivity will be evaluated with visual analog scale recording of pain scores associated with tongue range of motions in oral cancer patients.",[13],"Behavioral: Pressure and stretch sensitivity testing",{"label":15,"type":16,"description":17,"interventionNames":18},"Healthy Subjects","ACTIVE_COMPARATOR","Healthy subjects will be tested for pressure and stretch sensitivity. Pressure sensitivity will be evaluated with a digital pressure algometer by applying the probe tip to the tongues of healthy subjects.\n\nStretch sensitivity will be evaluated with visual analog scale recording of pain scores associated with tongue range of motions in healthy subjects.",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","Pressure and stretch sensitivity testing","We will measure pressure sensitivity by applying gradual pressure (50 kPa\u002Fs) at the site of testing using a digital pressure algometer. In healthy subjects, we will perform these measurements on the lateral tongue on the left and the right side. In cancer patients, we will first test on the unaffected contralateral matched site and then at the site of the cancer. We will define pressure sensitivity as the mean of three threshold measurements.\n\nFor measuring stretch sensitivity, we will use a visual analog scale (VAS) recording of pain scores associated with tongue stretching. Participants will be asked to perform tongue range of motions (ROM): protrusion, elevation, right and left lateralization, and rate sensitivity score on the VAS scale after holding the tongue in position for five seconds. We will define stretch sensitivity as the sum of VAS scores for protrusion, elevation, right and left lateralization.",[15,9],null,[27],{"name":28,"affiliation":29,"role":30},"Brian L Schmidt, DDS","NYU College of Dentistry","PRINCIPAL_INVESTIGATOR",[32,37],{"name":33,"role":34,"phone":35,"phoneExt":25,"email":36},"Yatendra Mulpuri, PhD","CONTACT","424-230-4222","ym2891@nyu.edu",{"name":38,"role":34,"phone":39,"phoneExt":25,"email":40},"Mariana Bucovsky, MHA","212-998-9389","mb10357@nyu.edu",[42],{"facility":29,"status":43,"city":44,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"RECRUITING","New York","10010","United States","US",{"type":49,"coordinates":50},"Point",[51,52],-74.00597,40.71427,{"lat":52,"lon":51},[55,56,57],{"name":33,"role":34,"phone":35,"phoneExt":25,"email":36},{"name":38,"role":34,"phone":39,"phoneExt":25,"email":40},{"name":28,"role":30,"phone":25,"phoneExt":25,"email":25},{"type":59,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR",[61],{"name":62,"class":63},"National Institute of Dental and Craniofacial Research (NIDCR)","NIH","100600293","defining-trpv4-contribution-of-schwann-cells-to-oral-cancer-pain-100600293",false,"NCT07095608","Defining TRPV4 Contribution of Schwann Cells to Oral Cancer Pain","Inclusion Criteria:\n\nFor healthy subjects to be eligible to participate in this study, an individual must meet all of the following criteria:\n\n* Provide signed and dated informed consent form\n* Willing to comply with all study procedures and be available for the duration of the study\n* Male or female, at least 18 years of age\n* In good general health as evidenced by medical history\n\nFor oral cancer patients to be eligible to participate in this study, an individual must meet all of the following criteria:\n\n* Provide signed and dated informed consent form\n* Willing to comply with all study procedures and be available for the duration of the study\n* Male or female, at least 18 years of age\n* Biopsy-proven squamous cell carcinoma (SCC) of the oral cavity that requires surgical resection\n* Lesion is at least 1 cm in greatest surface dimension\n\nExclusion Criteria:\n\n* Healthy subjects who meet any of the following criteria will be excluded from participation in this study:\n\n  * Clinically and\u002For histologically proven oral pre-cancer, oral cancer\n  * Pregnancy or lactation (Female subjects of child-bearing potential will have a rapid urine pregnancy test)\n  * Anything that would place the individual at increased risk or preclude the individual's full compliance with or completion of the study.\n\nOral cancer patients who meet any of the following criteria will be excluded from participation in this study:\n\n* History of prior surgical, chemotherapeutic, or radiation treatment for head and neck cancer\n* Pregnancy or lactation\n* Anything that would place the individual at increased risk or preclude the individual's full compliance with or completion of the study.\n\nFor participants with impaired kidney function (chronic kidney\u002Frenal disease) who wish to participate in the proposed research study, consultation with their primary care provider will be done prior to enrollment to determine safety",true,"ALL","18 Years",{"count":74,"type":75},80,"ESTIMATED","INTERVENTIONAL",[78],"NA","This is a prospective study involving human participants. Pressure and stretch sensitivity measures between oral cancer patients and healthy subjects will be compared. Pain stimulation will be conducted on the site of the cancer in 40 oral cancer patients, and on the tongue in 40 healthy volunteers, using pressure and stretch sensitivity tests.",[81,82],"Oral Cancer","Squamous Cell Carcinoma","2025-11-20",{"date":85,"type":86},"2025-11-21","ACTUAL",{"date":88,"type":86},"2025-09-01",{"date":90,"type":75},"2029-12-30",{"name":5,"class":6},1]