[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100555026":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":25,"locations":34,"responsibleParty":105,"collaborators":10,"id":107,"slug":108,"hasResults":109,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":113,"eligibilityCriteria":114,"healthyVolunteers":109,"sex":115,"minAge":116,"maxAge":117,"enrollmentInfo":118,"targetDuration":10,"studyType":121,"phases":10,"briefSummary":122,"conditions":123,"keywords":125,"overallStatus":37,"whyStopped":10,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":139,"locationsCount":140},{"fullName":5,"class":6},"University Hospital, Toulouse","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Dental Dyschromia in Hyperbilirubinemia Patients",null,"30 minutes",[13],"Other: Questionnaires",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"Questionnaires","* \" Psychosocial Impact of Dental Aesthetics Questionnaire \" PMID 24280547\n* \" Orofacial Esthetic Scale \" PMID 30856637\n* \" Orofacial Esthetic Scale \" PMID 34231057\n* A photograph of the patient's smile will be sent to 2 dentists who will also assess the presence or absence of dental dyschromia.",[9],[20],"Photograph",[22],{"name":23,"affiliation":5,"role":24},"Nolwen LABORDE, MD","PRINCIPAL_INVESTIGATOR",[26,31],{"name":27,"role":28,"phone":29,"phoneExt":10,"email":30},"Nolwenn LABORDE, MD","CONTACT","05 61 77 96 70","laborde.n@chu-toulouse.fr",{"name":32,"role":28,"phone":10,"phoneExt":10,"email":33},"Romain LOPEZ, PharmD","lopez.ro@chu-toulouse.fr",[35,47,55,63,71,79,87,92,97],{"facility":36,"status":37,"city":38,"state":10,"zip":10,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":10},"University Hospital Bordeaux","RECRUITING","Bordeaux","France","FR",{"type":42,"coordinates":43},"Point",[44,45],-0.58046,44.84124,{"lat":45,"lon":44},{"facility":48,"status":37,"city":49,"state":10,"zip":10,"country":39,"countryCode":40,"cosmosGeoPoint":50,"geoPoint":54,"contacts":10},"University Hosptial Caen","Caen",{"type":42,"coordinates":51},[52,53],-0.35912,49.18585,{"lat":53,"lon":52},{"facility":56,"status":37,"city":57,"state":10,"zip":10,"country":39,"countryCode":40,"cosmosGeoPoint":58,"geoPoint":62,"contacts":10},"University Hospital Lille","Lille",{"type":42,"coordinates":59},[60,61],3.05512,50.63391,{"lat":61,"lon":60},{"facility":64,"status":37,"city":65,"state":10,"zip":10,"country":39,"countryCode":40,"cosmosGeoPoint":66,"geoPoint":70,"contacts":10},"Hospices Civils de Lyon","Lyon",{"type":42,"coordinates":67},[68,69],4.84789,45.74906,{"lat":69,"lon":68},{"facility":72,"status":37,"city":73,"state":10,"zip":10,"country":39,"countryCode":40,"cosmosGeoPoint":74,"geoPoint":78,"contacts":10},"University Hospital Marseille","Marseille",{"type":42,"coordinates":75},[76,77],5.38107,43.29695,{"lat":77,"lon":76},{"facility":80,"status":37,"city":81,"state":10,"zip":10,"country":39,"countryCode":40,"cosmosGeoPoint":82,"geoPoint":86,"contacts":10},"Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, FHU Hépatinov","Paris",{"type":42,"coordinates":83},[84,85],2.3488,48.85341,{"lat":85,"lon":84},{"facility":88,"status":37,"city":81,"state":10,"zip":10,"country":39,"countryCode":40,"cosmosGeoPoint":89,"geoPoint":91,"contacts":10},"Assistance Publique-Hôpitaux de Paris, Hôpital Bretonneau, Paris",{"type":42,"coordinates":90},[84,85],{"lat":85,"lon":84},{"facility":93,"status":37,"city":81,"state":10,"zip":10,"country":39,"countryCode":40,"cosmosGeoPoint":94,"geoPoint":96,"contacts":10},"Assistance Publique-Hôpitaux de Paris, Hôpital Necker",{"type":42,"coordinates":95},[84,85],{"lat":85,"lon":84},{"facility":98,"status":37,"city":99,"state":10,"zip":10,"country":39,"countryCode":40,"cosmosGeoPoint":100,"geoPoint":104,"contacts":10},"University Hospital Rennes","Rennes",{"type":42,"coordinates":101},[102,103],-1.67431,48.11109,{"lat":103,"lon":102},{"type":106,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100555026","dental-dyschromia-and-quality-of-life-in-early-prolonged-hyperbilirubinemia-100555026",false,"NCT06506734","Dental Dyschromia and Quality of Life in Early Prolonged Hyperbilirubinemia","Prevalence of Dental Dyschromia and Impact on the Quality of Life of Participants With Prolonged Hyperbilirubinemia During Their Early Years","SMILE","Inclusion Criteria:\n\n* A patient with biliary atresia, progressive familial intrahepatic cholestasis, or Alagille syndrome\n* Patient or legal representative not opposed to participating in this research.\n\nExclusion Criteria:\n\n* Inability to understand and respond to quality of life questionnaires","ALL","12 Years","18 Years",{"count":119,"type":120},120,"ESTIMATED","OBSERVATIONAL","The main objective of this study is to assess the prevalence of dental discoloration (dental dyschromia) in children who experienced high levels of bilirubin in their blood (hyperbilirubinemia) during their early years. The study will also examine risk factors associated with this condition, such as the duration and severity of hyperbilirubinemia, underlying diseases, and treatments received.\n\nThe researchers hypothesize that the quality of life of individuals with dental dyschromia is lower than that of individuals without dyschromia. The results of this study will be used to discuss coverage for dental care with health insurance for children affected by this condition.",[124],"Dental Diseases",[126,127,128,129,130],"Hyperbilirubinemia","Biliary Atresia","Progressive Familial Intrahepatic Cholestasis (PFIC)","Alagille Syndrome","Tooth Discoloration","2026-05-07",{"date":133,"type":134},"2026-05-12","ACTUAL",{"date":136,"type":134},"2026-04-07",{"date":138,"type":120},"2027-10-07",{"name":5,"class":6},9]