[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100481333":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":7,"centralContacts":13,"locations":19,"responsibleParty":36,"collaborators":7,"id":38,"slug":39,"hasResults":40,"nctId":41,"briefTitle":42,"officialTitle":42,"acronym":43,"eligibilityCriteria":44,"healthyVolunteers":40,"sex":45,"minAge":46,"maxAge":7,"enrollmentInfo":47,"targetDuration":7,"studyType":50,"phases":7,"briefSummary":51,"conditions":52,"keywords":7,"overallStatus":22,"whyStopped":7,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":63},{"fullName":5,"class":6},"Fondation Ophtalmologique Adolphe de Rothschild","NETWORK",null,[9],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":7},"OTHER","sinusitis screening consultation","Questioning to look for suspicious anamnestic elements such as rhinorrhea, nasal obstruction, smell disorders, facial pain and clinical examination including nasofibroscopy.\n\nPatients with signs of sinusitis will be managed according to current recommendations (diagnostic imaging tests, medical treatment or even surgery if necessary).",[14],{"name":15,"role":16,"phone":17,"phoneExt":7,"email":18},"Amélie Yavchitz","CONTACT","+33148036454","ayavchitz@for.paris",[20],{"facility":21,"status":22,"city":23,"state":7,"zip":24,"country":25,"countryCode":26,"cosmosGeoPoint":27,"geoPoint":32,"contacts":33},"Hôpital Fondation A. de Rothschild","RECRUITING","Paris","75019","France","FR",{"type":28,"coordinates":29},"Point",[30,31],2.3488,48.85341,{"lat":31,"lon":30},[34],{"name":35,"role":16,"phone":7,"phoneExt":7,"email":7},"Raphaël LEJOYEUX",{"type":37,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100481333","detection-and-management-of-sinusitis-in-a-single-center-prospective-cohort-of-patients-with-exudative-amd-sine-100481333",false,"NCT05547633","Detection and Management of Sinusitis in a Single-center Prospective Cohort of Patients With Exudative AMD (SINE)","SINE","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Patient followed and treated for at least 2 years for bilateral neovascular form of age-related macular degeneration (AMD)\n* At least one eye treated with ≥ 6 intravitreal injections during the year preceding preinclusion\n* Express consent to participate in the study\n* Affiliated with or beneficiary of a social security plan\n\nExclusion Criteria:\n\n* Persons referred to in articles L1121-5 to L1121-8 of the CSP (corresponding to all protected persons: pregnant women, parturients, nursing mothers, persons deprived of liberty by judicial or administrative decision, minors, and persons under legal protection: guardianship or curatorship).\n* Severe myopia (\\> 6 diopters)\n* Patient already being treated for acute or chronic sinusitis\n* History of central serous chorioretinopathy or diffuse retinal epitheliopathy","ALL","18 Years",{"count":48,"type":49},200,"ESTIMATED","OBSERVATIONAL","An inflammatory component associated with AMD has been highlighted by genetic associations of predisposition to AMD, as well as by the recently demonstrated link between AMD and periodontitis.\n\nSome patients followed at the Fondation Adolphe de Rothschild Hospital for wet AMD seemed to show an improvement of neovascular activity (less need for intravitreal injections of anti-VEGF) after treatment of their sinusitis.\n\nThe investigators would therefore like to assess the link between AMD and sinusitis, an infection close to the site of AMD.",[53],"AMD","2025-12-03",{"date":56,"type":57},"2025-12-10","ACTUAL",{"date":59,"type":57},"2023-01-20",{"date":61,"type":49},"2028-04",{"name":5,"class":6},1]