[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100561425":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":10,"centralContacts":19,"locations":25,"responsibleParty":40,"collaborators":10,"id":42,"slug":43,"hasResults":44,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":44,"sex":49,"minAge":50,"maxAge":10,"enrollmentInfo":51,"targetDuration":10,"studyType":54,"phases":10,"briefSummary":55,"conditions":56,"keywords":10,"overallStatus":28,"whyStopped":10,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":67},{"fullName":5,"class":6},"Fondation Ophtalmologique Adolphe de Rothschild","NETWORK",[8],{"label":9,"type":10,"description":10,"interventionNames":11},"patients presenting to the imaging department in the context of inflammatory neuraxial disease",null,[12],"Diagnostic Test: MP2RAGE sequence",[14],{"type":15,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"DIAGNOSTIC_TEST","MP2RAGE sequence","Addition of MRI sequence MP2RAGE",[9],[20],{"name":21,"role":22,"phone":23,"phoneExt":10,"email":24},"Yavchitz","CONTACT","33 + 148036454","ayavchitz@for.paris",[26],{"facility":27,"status":28,"city":29,"state":10,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":32,"geoPoint":37,"contacts":38},"Hopital Fondation Adolphe de Rothschild","RECRUITING","Paris","France","FR",{"type":33,"coordinates":34},"Point",[35,36],2.3488,48.85341,{"lat":36,"lon":35},[39],{"name":21,"role":22,"phone":10,"phoneExt":10,"email":10},{"type":41,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100561425","detection-of-spinal-cord-lesions-using-the-mp2rage-sequence-in-inflammatory-diseases-of-the-neuraxis-100561425",false,"NCT06589999","Detection of Spinal Cord Lesions Using the MP2RAGE Sequence in Inflammatory Diseases of the Neuraxis","SCOUT-MS","Inclusion Criteria:\n\n* Patient aged over 18 years\n* scheduled to undergo 1.5T or 3T MRI of the spinal cord as part of an initial assessment or reassessment of inflammatory neuraxial disease.\n* Express consent to participate in the study\n* Member or beneficiary of a social security scheme\n\nExclusion Criteria:\n\n* Patient benefiting from a legal protection measure\n* Pregnant women\n* Absolute or relative contraindication to 1.5T or 3T MRI","ALL","18 Years",{"count":52,"type":53},196,"ESTIMATED","OBSERVATIONAL","Since the last revision of the MRI guidelines in multiple sclerosis (MS, MAGNIMS) and the McDonald criteria in 2017, all spinal cord lesions must be counted to increase the sensitivity and specificity of the diagnosis of MS. Focal lesions of the spinal cord are more frequently located in the cervical segments than in the lower segments of the spinal cord and occupy the lateral and posterior columns, although the central grey matter may not be spared. Cervical involvement is difficult to study because of the small size of the lesions and the loss of signal in the cervical region. As a result, the detection of cervical lesions on MRI is sub-optimal.\n\nIn this context, standardised acquisition protocols have been proposed.\n\nFor MRI of the spinal cord, at least two of the following sagittal sequences are recommended: T2, STIR, double inversion recovery, T1 with gadolinium injection, and\u002For T2 axial acquisitions.\n\nRecently, our team validated the superiority of 3D PSIR and 3D FGAPSIR sequences, which offer better detection performance than T2 and STIR on 3 Tesla MRI.\n\nOther studies have also shown the contribution of the MP2RAGE sequence to the detection of spinal cord lesions in MS, compared with the set of sequences classically recommended. The MP2RAGE sequence is a T1 sequence, which creates a composite image, limiting field inhomogeneity bias while providing a quantitative T1 map. It has recently been optimised for the spinal cord, and has been only minimally evaluated in the context of MS.\n\nThe aim of this study is to evaluate the effectiveness of the MP2RAGE sequence in comparison with the set of conventional sequences recommended for the detection of spinal cord lesions in MS patients.",[57],"Multiple Sclerosis","2025-12-30",{"date":60,"type":61},"2026-01-05","ACTUAL",{"date":63,"type":61},"2024-07-31",{"date":65,"type":53},"2026-07",{"name":5,"class":6},1]