[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100313186":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":11,"centralContacts":37,"locations":44,"responsibleParty":62,"collaborators":11,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":68,"acronym":69,"eligibilityCriteria":70,"healthyVolunteers":66,"sex":71,"minAge":72,"maxAge":11,"enrollmentInfo":73,"targetDuration":11,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":47,"whyStopped":11,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Central Hospital, Nancy, France","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Recipient","EXPERIMENTAL",null,[13,14],"Biological: Blood Sample","Biological: Bone marrow aspiration",{"label":16,"type":10,"description":11,"interventionNames":17},"Donor",[18,19],"Biological: Blood sample","Biological: Allogeneic hematopoietic stem cell sample",[21,26,30,34],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":11},"BIOLOGICAL","Blood Sample","Additional blood sample before graft, D0, D7, D15, D21, D30, D60, D90, D180, Y1, Y2",[9],{"type":22,"name":27,"description":28,"armGroupLabels":29,"otherNames":11},"Bone marrow aspiration","Additional bone marrow aspiration before graft, D30, D90, Y1",[9],{"type":22,"name":31,"description":32,"armGroupLabels":33,"otherNames":11},"Blood sample","Before donation",[16],{"type":22,"name":35,"description":35,"armGroupLabels":36,"otherNames":11},"Allogeneic hematopoietic stem cell sample",[16],[38],{"name":39,"role":40,"phone":41,"phoneExt":42,"email":43},"Marie-Thérèse RUBIO, PU-PH","CONTACT","0383153257","+33","m.rubio@chru-nancy.fr",[45],{"facility":46,"status":47,"city":48,"state":11,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"CHRU de Nancy","RECRUITING","Vandœuvre-lès-Nancy","54511","France","FR",{"type":53,"coordinates":54},"Point",[55,56],6.17114,48.66115,{"lat":56,"lon":55},[59],{"name":60,"role":40,"phone":61,"phoneExt":11,"email":11},"Marie-Thérèse RUBIO, Pr","0383153030",{"type":63,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100313186","determination-of-factors-involved-in-the-regulation-of-immune-responses-after-allogeneic-hematopoietic-stem-cell-transplantation-100313186",false,"NCT03357172","Determination of Factors Involved in the Regulation of Immune Responses After Allogeneic Hematopoietic Stem Cell Transplantation","REAL-GREFFE","Inclusion Criteria:\n\n* patient of the Nancy CHRU, for whom a CSH allograft is planned. or\n* hematopoietic stem cell donors received at Nancy's CHRU for the duration of the research\n\nExclusion Criteria:\n\n* Positive HIV\n* active hepatitis B or C infection","ALL","18 Years",{"count":74,"type":75},700,"ESTIMATED","INTERVENTIONAL",[78],"NA","The study concerns donors and patients receiving allogeneic stem cell haematopoietic transplantation. The aim of the study is to analyse HSC graft content in immune effector T (naive, memory, activated, exhausted) and immunoregulatory cell subtypes (Tregs, iNKT, MDSC) and correlate the results with post-transplant immune reconstitution of those different cell subtypes and clinical events (graft-versus-host-disease, relapse, infections). An ancillary study will focus on the impact of microbiota dysbiosis on post-transplant immune response and regulatory cell subsets.",[81],"Allogeneic Hematopoietic Stem Cell Transplantation",[83,84,85,86],"Immune recovery","Immunomodulatory cells","GVHD","GVL","2019-10-10",{"date":89,"type":90},"2019-10-14","ACTUAL",{"date":92,"type":90},"2019-10-01",{"date":94,"type":75},"2026-09-30",{"name":5,"class":6},1]