[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100625328":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":24,"centralContacts":30,"locations":40,"responsibleParty":56,"collaborators":24,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":68,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":24,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":83,"overallStatus":90,"whyStopped":24,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Afyonkarahisar Health Sciences University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Self-Adhesive Resin Cement Group","EXPERIMENTAL","In this split-mouth clinical study, stainless steel crowns placed on mandibular second primary molars (tooth 75) were cemented using a self-adhesive resin cement (G-Cem ONE™, GC, Japan). Clinical periodontal parameters (plaque index, gingival index, and bleeding on probing) and gingival crevicular fluid levels of interleukin-10 (IL-10), interleukin-12 (IL-12), and interleukin-18 (IL-18) were evaluated before treatment and one week after cementation.",[13],"Device: High-Viscosity Glass Ionomer Cement",{"label":15,"type":16,"description":17,"interventionNames":18},"High-Viscosity Glass Ionomer Cement Group","ACTIVE_COMPARATOR","In the contralateral quadrant of the same patients, stainless steel crowns placed on mandibular second primary molars (tooth 85) were cemented using a high-viscosity glass ionomer restorative material (EQUIA Forte™ HT, GC, Tokyo, Japan). Clinical periodontal parameters and gingival crevicular fluid cytokine levels (IL-10, IL-12, IL-18) were assessed before treatment and one week after cementation for comparison with the resin cement group.",[19],"Other: Self-Adhesive Resin Cement Group",[21,25],{"type":6,"name":9,"description":22,"armGroupLabels":23,"otherNames":24},"Stainless steel crowns were placed on mandibular second primary molars in systemically healthy children aged 6-10 years using a split-mouth design. After standard tooth preparation and crown adaptation, cementation was performed using two different luting materials. In one quadrant, crowns were cemented with a self-adhesive resin cement (G-Cem ONE™, GC, Japan), which provides chemical adhesion without the need for separate etching or bonding procedures. In the contralateral quadrant, crowns were cemented with a high-viscosity glass ionomer restorative material (EQUIA Forte™ HT, GC, Tokyo, Japan), characterized by fluoride release and conventional acid-base bonding properties.\n\nClinical periodontal parameters (plaque index, gingival index, bleeding on probing) and gingival crevicular fluid cytokine levels (IL-10, IL-12, IL-18) were evaluated before treatment and one week after cementation to assess early biological and clinical periodontal responses to the different cementation material",[15],null,{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":24},"DEVICE","High-Viscosity Glass Ionomer Cement","A high-viscosity glass ionomer restorative material (EQUIA Forte™ HT, GC, Tokyo, Japan) was used for cementation of stainless steel crowns according to standard clinical procedures.",[9],[31,36],{"name":32,"role":33,"phone":34,"phoneExt":24,"email":35},"OZGUR DOGAN, Associate Professor","CONTACT","905548714080","ozgurdogan1984@gmail.com",{"name":37,"role":33,"phone":38,"phoneExt":24,"email":39},"HATICE HATIPOGLU, RESEARCHER","+90 534 857 60 20","haticehhatipoglu@gmail.com",[41],{"facility":42,"status":24,"city":43,"state":24,"zip":24,"country":44,"countryCode":24,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Afyonkarahisar Health Science University","Afyonkarahisar","Turkey (Türkiye)",{"type":46,"coordinates":47},"Point",[48,49],30.54333,38.75667,{"lat":49,"lon":48},[52],{"name":53,"role":33,"phone":54,"phoneExt":24,"email":55},"MURAT YEŞİL, Associate Professor","+90 505 442 31 42","drmurat17@hotmail.com",{"type":57,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","Özgür Doğan","Associate Prof.","100625328","determination-of-the-effects-of-stainless-steel-crowns-cemented-with-resin-cements-on-interleukin-10-12-18-levels-in-gingival-crevicular-fluid-100625328",false,"NCT07421206","DETERMINATION OF THE EFFECTS OF STAINLESS STEEL CROWNS CEMENTED WITH RESIN CEMENTS ON INTERLEUKIN-10, 12, 18 LEVELS IN GINGIVAL CREVICULAR FLUID","Determination of the Effects of Stainless Steel Crowns Cemented With Resin Cements on Interleukin-10, Interleukin-12, and Interleukin-18 Levels in Gingival Crevicular Fluid","SSC-CYTO","Inclusion Criteria:\n\nChildren aged 6-10 years\n\nSystemically healthy pediatric patients\n\nPresence of bilateral mandibular second primary molars (teeth 75 and 85) requiring stainless steel crown restoration\n\nAbsence of clinical signs of active periodontal disease\n\nCooperative behavior sufficient to allow dental treatment and gingival crevicular fluid sampling\n\nWritten informed consent obtained from parents or legal guardians\n\nExclusion Criteria:\n\nPresence of systemic diseases or medical conditions affecting periodontal health or immune response\n\nUse of antibiotics, anti-inflammatory drugs, or immunosuppressive medications within the last month\n\nPoor oral hygiene or untreated periodontal disease\n\nTeeth with pulpal pathology, mobility, or advanced root resorption\n\nHistory of allergy to dental materials used in the study\n\nLack of parental consent or inability to complete follow-up examination",true,"ALL","6 Years","10 Years",{"count":73,"type":74},45,"ESTIMATED","INTERVENTIONAL",[77],"NA","This split-mouth clinical study aimed to evaluate the early effects of stainless steel crowns cemented with self-adhesive resin cement and high-viscosity glass ionomer cement on clinical periodontal parameters and interleukin-10 (IL-10), interleukin-12 (IL-12), and interleukin-18 (IL-18) levels in gingival crevicular fluid in pediatric patients. The study included 45 systemically healthy children aged 6-10 years. Stainless steel crowns were placed on the mandibular second primary molars (teeth 75 and 85) in each patient; tooth 75 was cemented with a self-adhesive resin cement (G-Cem ONE™, GC, Japan), while tooth 85 was cemented using a high-viscosity glass ionomer restorative material (EQUIA Forte™ HT, GC, Tokyo, Japan). Plaque index, gingival index, and bleeding on probing were recorded before treatment and one week after cementation. Gingival crevicular fluid samples were collected at the same time points, and IL-10, IL-12, and IL-18 levels were analyzed using the ELISA method. A statistically significant reduction in plaque index values was observed in both cement groups at the one-week follow-up (p\\\u003C0.001), whereas no significant differences were found in gingival index or bleeding on probing values (p\\>0.05). IL-10 and IL-12 levels did not change significantly in either group, whereas IL-18 levels decreased significantly in the resin cement group and were significantly higher in the glass ionomer cement group postoperatively. These findings suggest that although different cementation materials used for stainless steel crowns yield similar short-term clinical periodontal outcomes, material-related differences may exist in gingival biological responses, particularly with respect to IL-18 levels.",[80,81,82],"Dental Caries","Gingival Inflammation","Periodontal Response to Dental Restorative Materials",[84,85,86,87,88,89],"Stabnless steel crown","gingival crevicular fluid","interleukin-10","interleukin-12","interleukin-18","resin cement","NOT_YET_RECRUITING","2026-02-12",{"date":93,"type":94},"2026-02-19","ACTUAL",{"date":96,"type":74},"2026-02-16",{"date":98,"type":74},"2026-05-30",{"name":5,"class":6},1]