[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100638199":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":17,"centralContacts":27,"locations":35,"responsibleParty":52,"collaborators":54,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":59,"sex":65,"minAge":66,"maxAge":10,"enrollmentInfo":67,"targetDuration":10,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":78,"overallStatus":85,"whyStopped":10,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"King's College London","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"MANOEUVRE therapy",null,[12],"Other: MANOEUVRE therapy",[14],{"type":6,"name":9,"description":15,"armGroupLabels":16,"otherNames":10},"Virtual reality assisted psychological therapy for emotion regulation difficulties",[9],[18,21,24],{"name":19,"affiliation":5,"role":20},"Professor Dame Til Wykes","STUDY_CHAIR",{"name":22,"affiliation":5,"role":23},"Professor Matteo Cella","STUDY_DIRECTOR",{"name":25,"affiliation":5,"role":26},"Dr Caroline Lawlor","PRINCIPAL_INVESTIGATOR",[28,32],{"name":25,"role":29,"phone":30,"phoneExt":10,"email":31},"CONTACT","+44 7388 960630","caroline.lawlor@kcl.ac.uk",{"name":19,"role":29,"phone":33,"phoneExt":10,"email":34},"+44 20 7848 0596","Til.Wkyes@kcl.ac.uk",[36],{"facility":37,"status":10,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Institute of Psychiatry, Psychology & Neuroscience (IoPPN), King's College London","London","Greater London","SE5 8AF","United Kingdom","UK",{"type":44,"coordinates":45},"Point",[46,47],-0.12574,51.50853,{"lat":47,"lon":46},[50],{"name":25,"role":29,"phone":51,"phoneExt":10,"email":31},"+44 7388960630",{"type":53,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[55],{"name":56,"class":6},"South London and Maudsley NHS Foundation Trust","100638199","developing-a-virtual-reality-assisted-intervention-for-emotion-regulation-difficulties-in-psychosis-100638199",false,"NCT07623928","Developing a Virtual Reality-assisted Intervention for Emotion Regulation Difficulties in Psychosis","MANaging emOtions in Everyday Life Using Virtual REality (MANOEUVRE): Developing a VR-assisted Intervention for Emotion Regulation Difficulties in Psychosis","MANOEUVRE","Inclusion Criteria:\n\n* Currently under the care of South London and Maudsley (SLaM) National Health Service (NHS) outpatient services.\n* Clinical diagnosis of psychosis (schizophrenia spectrum disorder) (as assessed by their clinical team)\n* Willing to have the interview audio recorded (if taking part in post therapy interview)\n* Willing and able to provide informed consent to participate in the study (as assessed by their clinical team)\n\nExclusion Criteria:\n\n* Clinical presentation (e.g., immediate serious risk to self) (as assessed by their clinical team)\n* History of photosensitive epilepsy","ALL","18 Years",{"count":68,"type":69},15,"ESTIMATED","INTERVENTIONAL",[72],"NA","Supporting people with psychosis to manage their emotions using virtual reality\n\nMany people who have experienced psychosis feel overwhelmed by their emotions. Emotions get in the way of doing what matters to them. They want support to manage emotions differently. There is evidence that people with psychosis find talking therapies that teach skills for managing emotions helpful. People said it helped them to understand and manage their emotions. However, they also wanted more help to apply skills they learned to their lives.\n\nIt is hard to help people to use therapy skills in real-life situations. Therapists cannot be present when the skills are needed. One solution is to use virtual reality (VR) to bridge the gap between the clinic and real-life. VR involves using a headset to see and hear a very life-like computer-generated simulation of everyday life situations. People with psychosis find VR therapies engaging and helpful. It can feel safer to try things out in VR.\n\nGuided by the feedback of people with psychosis, this research will evaluate a novel therapy to help people with psychosis manage their emotions. Face-to- face therapy will be combined with VR so that people can practice emotion regulation skills safely with \"live\" coaching from a therapist. This should support people to use these skills when they need them.\n\nFifteen people with psychosis will be offered the therapy. Everyone will be asked what they think of it and complete questionnaires before and after therapy to see what impact it had on their lives.\n\nA lived experience advisory group will support all aspects of the research process.",[75,76,77],"Psychosis","SCHIZOPHRENIA 1 (Disorder)","Schizophrenia and Related Disorders",[79,75,80,81,82,83,84],"Emotion regulation","Virtual reality","Schizophrenia spectrum disorders","Virtual reality exposure therapy","Psychotherapy","Dialectical behaviour therapy","NOT_YET_RECRUITING","2026-05-28",{"date":88,"type":89},"2026-06-03","ACTUAL",{"date":91,"type":69},"2027-09-01",{"date":93,"type":69},"2028-11-01",{"name":5,"class":6},1]