[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100463306":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":31,"centralContacts":36,"locations":45,"responsibleParty":73,"collaborators":75,"id":79,"slug":80,"hasResults":81,"nctId":82,"briefTitle":83,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":86,"sex":87,"minAge":88,"maxAge":22,"enrollmentInfo":89,"targetDuration":22,"studyType":92,"phases":93,"briefSummary":95,"conditions":96,"keywords":98,"overallStatus":66,"whyStopped":22,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":112},{"fullName":5,"class":6},"Institut Pasteur","INDUSTRY",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"people over the age of 18 who agree to participate in the research.","EXPERIMENTAL","They are either people who have a hearing loss about 20 years older than their age and wear a hearing aid (or come in for a hearing aid), or people over the age of 40 with normal hearing for their age.",[13,14,15],"Other: Audiological and vestibular tests","Other: Blood sampling","Other: neurocognitive self-questionnaire",[17,23,27],{"type":18,"name":19,"description":20,"armGroupLabels":21,"otherNames":22},"OTHER","Audiological and vestibular tests","6h of audiological and vestibular tests divide in 3 sessions :\n\n* Session A : objective audiological tests\n* Session B ; subjective audiological tests\n* Session C : balance tests.",[9],null,{"type":18,"name":24,"description":25,"armGroupLabels":26,"otherNames":22},"Blood sampling","A 10 mL blood sample will be collected during the study.",[9],{"type":18,"name":28,"description":29,"armGroupLabels":30,"otherNames":22},"neurocognitive self-questionnaire","Four self-questionnaires to fill out to measure sleep quality, memory and emotional state",[9],[32],{"name":33,"affiliation":34,"role":35},"Paul Avan, MD","CERIAH","PRINCIPAL_INVESTIGATOR",[37,42],{"name":38,"role":39,"phone":40,"phoneExt":22,"email":41},"Celine Quinsac","CONTACT","+33 (0)1 76 53 50 29","celine.quinsac@pasteur.fr",{"name":33,"role":39,"phone":43,"phoneExt":22,"email":44},"+33 (0)1 76 53 50 94","paul.avan@uca.fr",[46,64],{"facility":47,"status":48,"city":49,"state":22,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Laboratoire de correction auditive","NOT_YET_RECRUITING","Paris","75001","France","FR",{"type":54,"coordinates":55},"Point",[56,57],2.3488,48.85341,{"lat":57,"lon":56},[60],{"name":61,"role":39,"phone":62,"phoneExt":22,"email":63},"Arnaud Coez, PharmD","+33 (0)1 42 96 87 70","arnaud.coez.ext@pasteur.fr",{"facility":65,"status":66,"city":49,"state":22,"zip":67,"country":51,"countryCode":52,"cosmosGeoPoint":68,"geoPoint":70,"contacts":71},"CEntre de Recherche et d'Innovation en Audiologie Humaine","RECRUITING","75012",{"type":54,"coordinates":69},[56,57],{"lat":57,"lon":56},[72],{"name":33,"role":39,"phone":43,"phoneExt":22,"email":44},{"type":74,"investigatorFullName":22,"investigatorTitle":22,"investigatorAffiliation":22,"oldNameTitle":22,"oldOrganization":22},"SPONSOR",[76,78],{"name":65,"class":77},"UNKNOWN",{"name":47,"class":77},"100463306","development-of-a-battery-of-audiological-tests-for-the-precision-diagnosis-of-age-related-hearing-loss-100463306",false,"NCT05312983","Development of a Battery of Audiological Tests for the Precision Diagnosis of Age-related Hearing Loss","AUDIOGENAGE","Inclusion Criteria:\n\nFor all participants:\n\n* Be over the age of 18,\n* Be affiliated to a social security system,\n* Have a good command of the French language (oral and written).\n\nFor the group of participants with anticipated presbycusis:\n\n* Over the age of 40, having a hearing aid recipient or coming for a first hearing aid recipient\n* Between 18 and 40, having a hearing aid recipient, coming for a first hearing aid recipient or declare a progressive genetic birth defect\n\nFor healthy volunteers:\n\n\\- Have no known hearing loss.\n\nExclusion Criteria:\n\n* Report having been chronically exposed to loud sounds.\n* Have a history of ototoxic substances,\n* To have sequelae of ear infections and\u002For a history of ENT disease that permanently affects hearing or balance,\n* Have an ethnic origin for which the Pasteur Institute does not have information on the frequency of variants of the genes studied.\n* Have type II diabetes,\n* Have a neurological or psychiatric condition that interferes with comprehension or ability to move,\n* Be under guardianship,\n* Be deprived of liberty by judicial or administrative decision, or be subject to legal protection,\n* Not being subject to a social security system,\n* Taking narcotic substances, alcohol or medication that diminishes cognitive abilities.",true,"ALL","18 Years",{"count":90,"type":91},700,"ESTIMATED","INTERVENTIONAL",[94],"NA","Age-related hearing loss, or presbycusis, is caused by many genetic and environmental factors. Its prevalence poses a public health challenge of early identification and effective hearing aid treatment. However, the lack of screening and of a validated audiological test battery to diagnose an individual's needs and to guide hearing aid adjustments is a major obstacle.\n\nFurthermore, monogenic forms of hearing loss affect only one functional module of hearing. The audiological test(s) dependent on the function of this module are affected, in a progressive manner, but not the others. A previous study showed that in early onset presbycusis patients, a quarter of the subjects tested were affected by monogenic presbycusis.\n\nThe collection of audiological and vestibular tests, carried out on proven monogenic presbycusis patients and compared to that of normal hearing patients, would constitute a battery of tests allowing a precision diagnosis, then developed to all forms of presbycusis in order to study if the identification of abnormal functional modules can usefully guide the diagnosis and the early fitting.",[97],"Presbyacusis",[99,100,101,102],"presbyacusis","aging","audiology","genetic","2025-02-28",{"date":105,"type":106},"2025-03-03","ACTUAL",{"date":108,"type":106},"2022-07-28",{"date":110,"type":91},"2030-12-31",{"name":5,"class":6},2]