[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100586698":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":10,"centralContacts":10,"locations":28,"responsibleParty":59,"collaborators":10,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":67,"eligibilityCriteria":68,"healthyVolunteers":63,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":75,"studyType":76,"phases":10,"briefSummary":77,"conditions":78,"keywords":80,"overallStatus":31,"whyStopped":10,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"King's College Hospital NHS Trust","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Focus group cohort",null,"Patients aged 18-100 with chronic cough including refractory chronic cough and unexplained chronic cough. Exclusions include: current smokers, ACE inhibitor use. Patients will be recruited to form focus groups to inform the creation of a cough control questionnaire. This will take the form of semi-structured interviews with open to closed questions. This same cohort will also engage in cognitive interviews after the preliminary cough control questionnaire has been made, to ensure that the language and wording is clear and appropriate. Recruitment will continue until thematic saturation is achieved.",[13],"Other: Focus group interviews",{"label":15,"type":10,"description":16,"interventionNames":10},"Validation study cohort","Patients aged 18-100 with chronic cough will be recruited. Exclusion criteria include: current smokers, smoking within the last 12 months, use of angiotensin converting enzyme inhibitor (ACEi), respiratory tract infection within the last 4 weeks and limited English.\n\nProspective consecutive patients with chronic cough will complete Cough Control Questionnaire, cough severity assessments and health status assessments. Patients will be invited to undergo objective cough frequency monitoring and cough challenge testing.",[18,21,25],{"type":6,"name":19,"description":20,"armGroupLabels":10,"otherNames":10},"Questionnaires","Completion of new questionnaire in addition to other patient reported outcome measures that measure cough severity and cough-related quality of life.",{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":10},"Focus group interviews","Semi-structured focus group interviews for patients with refractory chronic cough",[9],{"type":6,"name":26,"description":27,"armGroupLabels":10,"otherNames":10},"Objective cough measures","Cough monitoring and cough sensitivity testing.",[29],{"facility":30,"status":31,"city":32,"state":10,"zip":33,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"King's College Hospital","RECRUITING","London","SE5 9RS","United Kingdom","UK",{"type":37,"coordinates":38},"Point",[39,40],-0.12574,51.50853,{"lat":40,"lon":39},[43,49,52,55,57],{"name":44,"role":45,"phone":46,"phoneExt":47,"email":48},"Ewan Mackay, MBBS, BSc, MRCP","CONTACT","02032999000","31096","ewan.mackay@nhs.net",{"name":50,"role":45,"phone":46,"phoneExt":47,"email":51},"Katie Rhatigan, MSc","k.rhatigan@nhs.net",{"name":53,"role":54,"phone":10,"phoneExt":10,"email":10},"Surinder Birring, MB ChB, BSc, MD, MRCP","PRINCIPAL_INVESTIGATOR",{"name":44,"role":56,"phone":10,"phoneExt":10,"email":10},"SUB_INVESTIGATOR",{"name":58,"role":56,"phone":10,"phoneExt":10,"email":10},"Peter Cho, MBBS, PhD, MRCP",{"type":60,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100586698","development-of-a-cough-control-questionnaire-ccq-100586698",false,"NCT06918756","Development of a Cough Control Questionnaire (CCQ)","The Development and Validation of a Cough Control Questionnaire","CCQ","Inclusion Criteria:\n\n* Adult patients aged 18 and over with acute and chronic cough (including refractory chronic cough and unexplained chronic cough) and able to read and write in English. A smaller number (n =20) of healthy volunteers will also be included with no evidence of significant respiratory disease.\n\nExclusion Criteria:\n\n* Current smokers (or smoking within the last 12 months), respiratory tract infection within the last 4 weeks, use of angiotensin converting enzyme inhibitors (ACEi), and pregnancy","ALL","18 Years","100 Years",{"count":73,"type":74},100,"ESTIMATED","7 Years","OBSERVATIONAL","Chronic cough (\\>8 weeks in duration) affects 5-12% of the global population, and is associated with considerable health status impairment and comorbidities. Currently, there are validated severity and impact outcome measures whilst objective measures with cough frequency monitoring is not available in routine clinical practice. Unlike other chronic respiratory diseases, namely asthma, there are no validated dedicated tools to assess the control of cough as a disease.\n\nThis study aims to develop a validated patient-focused tool to assess the control of cough, which may be useful to evaluate the benefit and value of treatments in both clinical and research settings.",[79],"Cough",[81,82,83,84],"patient-reported outcomes","cough","control","questionnaire","2025-04-01",{"date":87,"type":88},"2025-04-09","ACTUAL",{"date":85,"type":88},{"date":91,"type":74},"2031-09-01",{"name":5,"class":6},1]