[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100608056":3},{"organization":4,"armGroups":7,"interventions":27,"overallOfficials":11,"centralContacts":11,"locations":11,"responsibleParty":47,"collaborators":51,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":11,"eligibilityCriteria":60,"healthyVolunteers":61,"sex":62,"minAge":63,"maxAge":11,"enrollmentInfo":64,"targetDuration":11,"studyType":67,"phases":68,"briefSummary":70,"conditions":71,"keywords":11,"overallStatus":73,"whyStopped":11,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":11},{"fullName":5,"class":6},"Tongji University","OTHER",[8,14,18,22],{"label":9,"type":10,"description":11,"interventionNames":12},"Olfactory Stimulation Group","EXPERIMENTAL",null,[13],"Behavioral: Olfactory stimulation",{"label":15,"type":10,"description":11,"interventionNames":16},"TI Stimulation Group",[17],"Biological: Temporal Interference,TI",{"label":19,"type":10,"description":11,"interventionNames":20},"Olfactory-TI Stimulation Group",[21],"Combination Product: Olfactory-TI Stimulation",{"label":23,"type":24,"description":11,"interventionNames":25},"Sham Control Group","SHAM_COMPARATOR",[26],"Combination Product: Sham Control",[28,33,38,43],{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":11},"BEHAVIORAL","Olfactory stimulation","Olfactory stimulation were set as follows:\n\nEssential oil types: yuzu, lavender, lemon, and mint. Concentration: 158 μL of essential oil + 50 mL of water. The mixed solution was poured into the test tubes of the olfactory instrument, ensuring that the liquid levels of the four solutions were kept at the same height. Each scent was released for 30 seconds, followed by a 10-second air interval, with each cycle lasting 20 minutes.",[9],{"type":34,"name":35,"description":36,"armGroupLabels":37,"otherNames":11},"BIOLOGICAL","Temporal Interference,TI","During stimulation, the parameters were set as follows:\n\nΔf=40Hz (2000Hz vs. 2040Hz) 2mA Stimulation duration: 20min We fixed the stimulation protocol and used a standard head to simulate stimulation of the entorhinal region.",[15],{"type":39,"name":40,"description":41,"armGroupLabels":42,"otherNames":11},"COMBINATION_PRODUCT","Olfactory-TI Stimulation","During stimulation, the parameters were set as follows:\n\nΔf=40Hz (2000Hz vs. 2040Hz) 2mA Stimulation duration: 20min We fixed the stimulation protocol and used a standard head to simulate stimulation of the entorhinal region.\n\nOlfactory stimulation were set as follows:\n\nEssential oil types: yuzu, lavender, lemon, and mint. Concentration: 158 μL of essential oil + 50 mL of water. The mixed solution was poured into the test tubes of the olfactory instrument, ensuring that the liquid levels of the four solutions were kept at the same height. Each scent was released for 30 seconds, followed by a 10-second air interval, with each cycle lasting 20 minutes.",[19],{"type":39,"name":44,"description":45,"armGroupLabels":46,"otherNames":11},"Sham Control","During stimulation, the parameters were set as follows:\n\nΔf=0Hz (2000Hz vs. 2000Hz) 2mA Stimulation duration: 20min.\n\nOlfactory stimulation were set as follows:\n\nEssential oil types: air. lasting 20 minutes.",[23],{"type":48,"investigatorFullName":49,"investigatorTitle":50,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"SPONSOR_INVESTIGATOR","Yuan Shen","MD., Ph.D.",[52],{"name":53,"class":6},"Shanghai Mental Health Center","100608056","development-of-a-novel-multidimensional-therapeutic-intervention-protocol-for-mci-100608056",false,"NCT07196592","Development of a Novel Multidimensional Therapeutic Intervention Protocol for MCI","AD New Multi-Dimensional Therapy Device Development - Microcurrent Brain Stimulation Device and Virtual Reality Therapy Equipment","Inclusion Criteria:\n\nBaseline screening inclusion criteria: a) Age ≤ 65 years and ≤ 85 years; b) Education duration ≥ 1 year; c) Normal cognitive function at enrollment: MMSE total score: non-illiterate (primary school or below) ≥ 20 points, primary school or above ≥ 24 points; d) Corrected vision and hearing are basically normal, and able to complete cognitive assessment.\n\nExclusion Criteria:\n\nBaseline screening exclusion criteria: a) Neurological\u002Fpsychiatric disorders affecting cognitive function: depression, schizophrenia, mental retardation, Parkinson's disease, etc.; b) Severe physical illnesses: cardiovascular disease, cerebrovascular disease, tumors, diabetes, kidney disease, and hypertension stage III or above; c) Autoimmune inflammatory diseases such as rheumatoid arthritis, lupus erythematosus, osteoarthritis, and multiple sclerosis.",true,"ALL","60 Years",{"count":65,"type":66},300,"ESTIMATED","INTERVENTIONAL",[69],"NA","As populations age, Alzheimer's disease (AD) is increasing while disease-modifying drugs remain elusive, making early diagnosis and intervention essential. Building on advances in neuromodulation and virtual reality (VR), we target amnestic mild cognitive impairment (aMCI)-the prodromal stage of AD-as a key window for prevention. Preliminary evidence shows disrupted theta-delta phase-amplitude coupling in prefrontal and temporal cortices in aMCI, whereas olfactory enrichment can enhance hippocampal synaptic function, improve cognition, and potentially lower AD risk. We will conduct a large-scale clinical cohort study to test the neural mechanisms and clinical efficacy of multi-site, cross-frequency transcranial alternating current stimulation (tACS) combined with multisensory (visual-olfactory-auditory) VR. A comprehensive database spanning demographic, neuropsychological, biochemical, neuroimaging, and neuromodulation parameters will guide optimal protocols and provide objective evidence for non-pharmacological interventions, informing development of a microcurrent brain stimulator and a portable VR device.",[72],"MCI-AD, Early Stage Alzheimer's Disease","NOT_YET_RECRUITING","2025-09-20",{"date":76,"type":77},"2025-09-29","ACTUAL",{"date":79,"type":66},"2025-10-01",{"date":81,"type":66},"2026-12-01",{"name":49,"class":6}]