[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100638155":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":32,"centralContacts":36,"locations":45,"responsibleParty":63,"collaborators":31,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":72,"eligibilityCriteria":73,"healthyVolunteers":68,"sex":74,"minAge":31,"maxAge":31,"enrollmentInfo":75,"targetDuration":31,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":31,"overallStatus":87,"whyStopped":31,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"University of Baghdad","OTHER",[8,14,18,22],{"label":9,"type":10,"description":11,"interventionNames":12},"control group","EXPERIMENTAL","Directly 3D-printed orthodontic aligner resin",[13],"Other: Modified 3D-Printed Orthodontic Aligner Resin",{"label":15,"type":10,"description":16,"interventionNames":17},"DMAHDM group","Directly 3D-printed orthodontic aligner resin with incorporation of dimethylaminohexadecyl methacrylate (DMAHDM)",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"ACP group","Directly 3D-printed orthodontic aligner resin with incorporation of Amorphous calcium phosphate (ACP)",[13],{"label":23,"type":10,"description":24,"interventionNames":25},"DMAHDM + ACP group","Directly 3D-printed orthodontic aligner resin with incorporation both DMAHDM and ACP",[13],[27],{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"Modified 3D-Printed Orthodontic Aligner Resin","Directly 3D-printed orthodontic aligner resin with or without incorporation of antimicrobial (DMAHDM) and remineralizing (ACP) agents.",[19,23,15,9],null,[33],{"name":34,"affiliation":5,"role":35},"Ali I Ibrahim, Prof. Dr","STUDY_CHAIR",[37,42],{"name":38,"role":39,"phone":40,"phoneExt":31,"email":41},"Safaa Saud Abed","CONTACT","009647712375540","safaasaud83@gmail.com",{"name":43,"role":39,"phone":31,"phoneExt":31,"email":44},"Ali I Ibrahim","ali.ibrahim@kcl.ac.uk",[46],{"facility":47,"status":31,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"College of Dentistry, University of Baghdad","Baghdad","Baghdad Governorate","1417","Iraq","IQ",{"type":54,"coordinates":55},"Point",[56,57],44.40088,33.34058,{"lat":57,"lon":56},[60],{"name":61,"role":39,"phone":62,"phoneExt":31,"email":44},"Ali I Ibrahim, professor of orthodontics","00964 7705814633",{"type":64,"investigatorFullName":38,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"PRINCIPAL_INVESTIGATOR","postgraduate\u002FPhD student","100638155","development-of-biofunctional-3d-printed-orthodontic-aligners-with-antimicrobial-and-remineralizing-properties-100638155",false,"NCT07603427","Development of Biofunctional 3D-Printed Orthodontic Aligners With Antimicrobial and Remineralizing Properties","Development of Biofunctional 3D Printed Orthodontic Aligners Enriched With Remineralizing and Anti-microbial Agents","3D-BIOALIGN","Inclusion Criteria:\n\n* Extracted human teeth obtained for reasons unrelated to this study (e.g., orthodontic or periodontal indications).\n* Teeth collected after obtaining ethical approval from the Research Ethics Committee.\n* Teeth free from visible cracks, fractures, restorations, or developmental defects.\n\nExclusion Criteria:\n\n* \\- Teeth with caries, restorations, cracks, fractures, or structural defects.\n* Teeth extracted due to pathological conditions affecting enamel or dentin integrity.\n* Teeth with unknown extraction history","ALL",{"count":76,"type":77},400,"ESTIMATED","INTERVENTIONAL",[80],"NA","Clear orthodontic aligners are widely used due to their esthetics and patient comfort; however, prolonged wear may promote biofilm accumulation and enamel demineralization. This laboratory-based (in vitro) study aims to develop and evaluate a novel directly 3D-printed orthodontic aligner resin modified with antimicrobial and remineralizing agents.\n\nThe study will investigate the incorporation of dimethylaminohexadecyl methacrylate (DMAHDM) as an antibacterial agent and amorphous calcium phosphate (ACP) as a remineralizing component into a 3D-printed aligner resin. Modified and unmodified resin specimens will be fabricated and assessed for antimicrobial activity, ion release, and enamel remineralization potential using extracted human teeth.\n\nIn addition, the mechanical and physical properties of the experimental aligner materials, including shape memory behavior, deflection, tensile strength, translucency, and water sorption, will be evaluated to ensure clinical suitability.\n\nThis study does not involve human participants and is conducted entirely in vitro. The findings are expected to contribute to the development of biofunctional orthodontic aligners that actively inhibit bacterial growth and support enamel health without compromising material performance",[83,84,85,86],"Orthodontic Aligner Material","Enamel Demineralization","Dental Biofilm Formation","Clear Aligner Material Properties","NOT_YET_RECRUITING","2026-05-15",{"date":90,"type":91},"2026-05-22","ACTUAL",{"date":93,"type":77},"2026-06-01",{"date":95,"type":77},"2027-02-01",{"name":5,"class":6},1]