[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100592923":3},{"organization":4,"armGroups":7,"interventions":30,"overallOfficials":47,"centralContacts":52,"locations":62,"responsibleParty":77,"collaborators":34,"id":79,"slug":80,"hasResults":81,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":34,"eligibilityCriteria":85,"healthyVolunteers":81,"sex":86,"minAge":87,"maxAge":88,"enrollmentInfo":89,"targetDuration":34,"studyType":92,"phases":93,"briefSummary":95,"conditions":96,"keywords":34,"overallStatus":98,"whyStopped":34,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":108},{"fullName":5,"class":6},"National Cheng-Kung University Hospital","OTHER",[8,14,20,25],{"label":9,"type":10,"description":11,"interventionNames":12},"Sleep hygiene education","SHAM_COMPARATOR","Receive monthly sleep hygiene education",[13],"Other: Control",{"label":15,"type":16,"description":17,"interventionNames":18},"Oropharyngeal rehabilitation","EXPERIMENTAL","Receive oropharyngeal rehabilitation training over three months",[19],"Device: Oropharyngeal Exercise",{"label":21,"type":16,"description":22,"interventionNames":23},"Continuous positive airway pressure","Receive continuous positive airway pressure",[24],"Device: Continuous positive airway pressure",{"label":26,"type":16,"description":27,"interventionNames":28},"Continuous positive airway pressure and oropharyngeal rehabilitation","Receive continuous positive airway pressure and oropharyngeal rehabilitation training for three months",[29],"Device: Continuous positive airway pressure and oropharyngeal exercise",[31,35,40,43],{"type":6,"name":32,"description":9,"armGroupLabels":33,"otherNames":34},"Control",[9],null,{"type":36,"name":37,"description":38,"armGroupLabels":39,"otherNames":34},"DEVICE","Oropharyngeal Exercise","Device-monitoring oropharyngeal exercise, 1-5 days a week for three months",[15],{"type":36,"name":21,"description":41,"armGroupLabels":42,"otherNames":34},"Continuous positive airway pressure, 1-5 days a week for three months",[21],{"type":36,"name":44,"description":45,"armGroupLabels":46,"otherNames":34},"Continuous positive airway pressure and oropharyngeal exercise","Continuous positive airway pressure and device-monitoring oropharyngeal exercise, 1-5 days a week for three months",[26],[48],{"name":49,"affiliation":50,"role":51},"Ching-Hsia Hung, PhD","National Cheng Kung University","PRINCIPAL_INVESTIGATOR",[53,58],{"name":54,"role":55,"phone":56,"phoneExt":34,"email":57},"Chieh-Yu Liu, MS","CONTACT","+886-988-613-312","chiehyu0506@gmail.com",{"name":49,"role":55,"phone":59,"phoneExt":60,"email":61},"+886-6-2353535","5939","chhung@mail.ncku.edu.tw",[63],{"facility":64,"status":34,"city":65,"state":34,"zip":66,"country":67,"countryCode":68,"cosmosGeoPoint":69,"geoPoint":74,"contacts":75},"National Cheng Kung University Hospital","Tainan","704","Taiwan","TW",{"type":70,"coordinates":71},"Point",[72,73],120.21333,22.99083,{"lat":73,"lon":72},[76],{"name":49,"role":55,"phone":59,"phoneExt":60,"email":61},{"type":78,"investigatorFullName":34,"investigatorTitle":34,"investigatorAffiliation":34,"oldNameTitle":34,"oldOrganization":34},"SPONSOR","100592923","device-assisted-oropharyngeal-rehabilitation-in-obstructive-sleep-apnea-patients-using-continuous-positive-airway-pressure-100592923",false,"NCT06999746","Device-Assisted Oropharyngeal Rehabilitation in Obstructive Sleep Apnea Patients Using Continuous Positive Airway Pressure","Effectiveness of Using Force Sensing Resistor to Assist Oropharyngeal Rehabilitation in Patients With Obstructive Sleep Apnea Using Continuous Positive Airway Pressure","Inclusion Criteria:\n\n* Adults aged 20 to 68 years\n* Newly diagnosed with mild to severe pure obstructive sleep apnea based on polysomnography\n\nExclusion Criteria:\n\n* Severe allergic rhinitis\n* Sinusitis with nasal polyps\n* Adenoid hypertrophy\n* Bilateral tonsillar hypertrophy (Friedman grade ≥ III)\n* Lingual tonsil hypertrophy (Friedman grade ≥ III)\n* Body Mass Index (BMI) \\> 40\n* Alcohol or drug abuse within the past year\n* Pregnancy\n* Severe obstructive or restrictive pulmonary diseases\n* High-risk cardiovascular diseases during exercise (e.g., angina, myocardial infarction, heart failure, valvular heart disease)\n* History of central or peripheral neurological disorders that interfere with exercise prescription\n* Musculoskeletal or psychological disorders that interfere with exercise prescription\n* Other non-respiratory sleep disorders\n* Sleep disorders with concomitant central sleep apnea","ALL","20 Years","68 Years",{"count":90,"type":91},200,"ESTIMATED","INTERVENTIONAL",[94],"NA","The goal of this clinical trial is to evaluate the effectiveness of device-assisted oropharyngeal rehabilitation (OPR) in improving upper airway muscle function and reducing obstructive sleep apnea (OSA) severity in adult patients diagnosed with OSA who are receiving continuous positive airway pressure (CPAP) therapy.\n\nThe main questions it aims to answer are:\n\n1. Does combining OPR with CPAP increase upper airway space volume compared to using CPAP alone?\n2. Does OPR improve tongue muscle strength, and is this improvement associated with reduced CPAP pressure requirements?\n3. Do patients receiving OPR (alone or combined with CPAP) show greater improvements in OSA severity and clinical symptoms compared to those receiving CPAP alone or no intervention? Researchers will compare four groups-Control, OPR-only, CPAP-only, and CPAP + OPR-to see if device-assisted OPR enhances treatment outcomes beyond CPAP alone.\n\nParticipants will:\n\n1. Be randomly assigned to one of four groups (Control, OPR-only, CPAP-only, CPAP+OPR).\n2. Perform home-based OPR exercises (30-45 minutes\u002Fsession, 1-2 sessions\u002Fday, 3-5 days\u002Fweek for 3 months) in the OPR and CPAP+OPR groups.\n3. Have their exercise monitored using a strength sensor, with intensity adjusted every 2-4 weeks during hospital visits.\n4. Undergo assessments before and after the intervention, including:\n\n(1) Polysomnography for OSA severity, (2) CT and ultrasound for upper airway and tongue muscle structure, (3) Tongue muscle strength\u002Fendurance tests, (4) Sleep quality questionnaires, (5) CPAP usage and pressure reports.",[97],"Obstructive Sleep Apnea","NOT_YET_RECRUITING","2025-05-22",{"date":101,"type":102},"2025-05-31","ACTUAL",{"date":104,"type":91},"2025-06-15",{"date":106,"type":91},"2029-12-31",{"name":5,"class":6},1]