[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100592744":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":29,"locations":35,"responsibleParty":50,"collaborators":11,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":11,"eligibilityCriteria":59,"healthyVolunteers":55,"sex":60,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":11,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":11,"overallStatus":37,"whyStopped":11,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"Beijing Tiantan Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Dexamethasone palmitate group","EXPERIMENTAL",null,[13],"Drug: Dexamethasone Palmitate",{"label":15,"type":16,"description":11,"interventionNames":17},"Dexamethasone group","ACTIVE_COMPARATOR",[18],"Drug: Dexamethasone",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"DRUG","Dexamethasone Palmitate","Patients in the dexamethasone palmitate group will be assigned to receive intravenous injection of dexamethasone palmitate 8 mg (contains 5mg dexamethasone) after anesthesia induction and before surgical incision.",[9],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"Dexamethasone","Patients in the dexamethasone group will be assigned to receive intravenous injections of dexamethasone 5 mg after anesthesia induction and before surgical incision.",[15],[30],{"name":31,"role":32,"phone":33,"phoneExt":11,"email":34},"Fang Luo","CONTACT","59976661","13611326978@163.com",[36],{"facility":31,"status":37,"city":38,"state":11,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"RECRUITING","Beijing","100050","China","CN",{"type":43,"coordinates":44},"Point",[45,46],116.39723,39.9075,{"lat":46,"lon":45},[49],{"name":31,"role":32,"phone":33,"phoneExt":11,"email":34},{"type":51,"investigatorFullName":31,"investigatorTitle":52,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Director of Department of Pain Management","100592744","dexamethasone-palmitate-for-ponv-after-open-surgery-100592744",false,"NCT06997419","Dexamethasone Palmitate for PONV After Open Surgery","Intravenous Dexamethasone Palmitate for Prophylaxis of Postoperative Nausea and Vomiting After Open Surgery","Inclusion Criteria:\n\n* Aged 18 to 65 years;\n* Providing written informed consent;\n* Perform elective open surgery (Spinal surgery, open chest surgery, open abdominal surgery) undergoing general anesthesia.\n\nExclusion Criteria:\n\n* Known to be allergic to dexamethasone;\n* Any systemic glucocorticoids within 3 months before trial entry;\n* History of severe heart disease, liver\u002Fkidney failure, or systemic rheumatic diseases (rheumatoid arthritis, ankylosing spondylitis, systemic lupus erythematosus, et al);\n* Cognitive impairment or severe mental illness;\n* Uncontrolled diabetes or infectious diseases;\n* Pregnancy or breastfeeding.","ALL","18 Years","65 Years",{"count":64,"type":65},500,"ESTIMATED","INTERVENTIONAL",[68],"NA","Dexamethasone is almost one of the most commonly used drugs for postoperative nausea and vomiting (PONV) prevention. However, PONV is still a complex problem to be solved; for example, even with preoperative dexamethasone administration, there are still some patients still experience PONV within 24 hours postoperatively. Compared to dexamethasone, dexamethasone palmitate has a long-lasting anti-inflammatory effect, 2-5 times that of traditional water-soluble dexamethasone, with fewer adverse effects. This trial aims to assess the effect and safety of preoperative dexamethasone palmitate on PONV after open surgery.",[71,22,72],"Postoperative Nausea and Vomiting","Open Surgery","2025-09-21",{"date":75,"type":76},"2025-09-23","ACTUAL",{"date":78,"type":76},"2025-07-01",{"date":80,"type":65},"2026-12-31",{"name":5,"class":6},1]