[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100586074":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":30,"centralContacts":37,"locations":43,"responsibleParty":65,"collaborators":30,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":30,"eligibilityCriteria":74,"healthyVolunteers":70,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":30,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":30,"overallStatus":45,"whyStopped":30,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Dexmedetomidine group","EXPERIMENTAL","Patients will receive 1 μg\u002Fkg of intravenous dexmedetomidine over 10 min followed by an intravenous infusion of 0.5 μg\u002Fkg\u002Fh.",[13],"Drug: Dexmedetomidine",{"label":15,"type":10,"description":16,"interventionNames":17},"Lidocaine group","Patients will receive a bolus of intravenous lidocaine 1.5mg\u002Fkg over 10 min followed by a continuous infusion of lidocaine 1.5mg\u002Fkg\u002Fh.",[18],"Drug: Lidocaine",{"label":20,"type":21,"description":22,"interventionNames":23},"Control group","PLACEBO_COMPARATOR","Patients will receive intravenous isotonic saline 0.9% in the same volume and manner as the study drugs.",[24],"Drug: Isotonic saline",[26,31,34],{"type":27,"name":28,"description":11,"armGroupLabels":29,"otherNames":30},"DRUG","Dexmedetomidine",[9],null,{"type":27,"name":32,"description":16,"armGroupLabels":33,"otherNames":30},"Lidocaine",[15],{"type":27,"name":35,"description":22,"armGroupLabels":36,"otherNames":30},"Isotonic saline",[20],[38],{"name":39,"role":40,"phone":41,"phoneExt":30,"email":42},"Mohamed E Abdel Fattah, MD","CONTACT","00201284475792","mohamed-elsaid@cu.edu.eg",[44],{"facility":5,"status":45,"city":46,"state":30,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"RECRUITING","Cairo","12613","Egypt","EG",{"type":51,"coordinates":52},"Point",[53,54],31.24967,30.06263,{"lat":54,"lon":53},[57,58,61,63],{"name":39,"role":40,"phone":41,"phoneExt":30,"email":42},{"name":59,"role":60,"phone":30,"phoneExt":30,"email":30},"Samuel F Samy, MD","PRINCIPAL_INVESTIGATOR",{"name":62,"role":60,"phone":30,"phoneExt":30,"email":30},"Norma O Zayed, MD",{"name":64,"role":60,"phone":30,"phoneExt":30,"email":30},"Mohammed ElSharkawy, MD",{"type":60,"investigatorFullName":66,"investigatorTitle":67,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"Mohamed Elsaid Abdel Fattah","Lecturer of Anesthesia, Surgical ICU and Pain Management, Faculty of Medicine, National Cancer Institute, Cairo University, Egypt.","100586074","dexmedetomidine-versus-lidocaine-infusions-as-adjuvants-to-general-anesthesia-for-chronic-pain-management-after-mastectomy-100586074",false,"NCT06910644","Dexmedetomidine Versus Lidocaine Infusions as Adjuvants to General Anesthesia for Chronic Pain Management After Mastectomy","Dexmedetomidine Versus Lidocaine Infusions as Adjuvants to General Anesthesia for Chronic Pain Management After Mastectomy: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age from 18 to 75 years.\n* American Society of Anesthesiologists (ASA) physical status II.\n* Scheduled for mastectomy with axillary dissection (either modified radical mastectomy with or without latissimus dorsi flap or conservative breast surgery) due to breast cancer.\n\nExclusion Criteria:\n\n* Patient refusal.\n* Known allergy to any of the study drugs.\n* Those with hepatic or renal insufficiency.\n* Patients who are running regularly on B blockers.\n* α2 adrenergic agonists and sedatives.\n* Psychoactive medications.","FEMALE","18 Years","75 Years",{"count":79,"type":80},90,"ESTIMATED","INTERVENTIONAL",[83],"NA","This study aims to compare dexmedetomidine and lidocaine infusions as adjuvants to general anesthesia for chronic pain management after mastectomy.",[28,32,86,87,88,89,90],"Infusion","Adjuvants","General Anesthesia","Chronic Pain","Mastectomy","2025-04-05",{"date":93,"type":94},"2025-04-08","ACTUAL",{"date":91,"type":94},{"date":97,"type":80},"2025-12-01",{"name":5,"class":6},1]