[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100608287":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":25,"responsibleParty":39,"collaborators":25,"id":43,"slug":44,"hasResults":45,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":25,"eligibilityCriteria":49,"healthyVolunteers":45,"sex":50,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":25,"studyType":56,"phases":57,"briefSummary":59,"conditions":60,"keywords":25,"overallStatus":62,"whyStopped":25,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":25},{"fullName":5,"class":6},"Assiut University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Dexmedetomidine","ACTIVE_COMPARATOR","Dexmedetomidine: loading dose 1 µg\u002Fkg IV over 10 min after induction and then maintenance dose 0.2- 0.7 µg\u002Fkg\u002Fhr based on hemodynamic response",[13],"Drug: Dexamedomedine",{"label":15,"type":10,"description":16,"interventionNames":17},"Mgso4","Magnesium Sulfate: Used as an IV loading dose at 20 mg\u002Fkg IV over 17 minutes as an induction agent, followed by maintenance of 10 mg\u002Fkg\u002Fh to skin closure.",[18],"Drug: MgSO4",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Dexamedomedine","Group A (the Dexmedetomidine group):\n\nDexmedetomidine: loading dose 1 µg\u002Fkg IV over 10 min after induction and then maintenance dose 0.2- 0.7 µg\u002Fkg\u002Fhr based on hemodynamic response.",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"MgSO4","Magnesium Sulfate: Used as an IV loading dose at 20 mg\u002Fkg IV over 17 minutes as an induction agent, followed by maintenance of 10 mg\u002Fkg\u002Fh",[15],[31,36],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Hassan mostafa, Assistant lecturer","CONTACT","01060264751","hassan.mostafa9444@gmail.com",{"name":37,"role":33,"phone":25,"phoneExt":25,"email":38},"Ghada Aboalfadl, Professor","ghadafadl77@gmail.com",{"type":40,"investigatorFullName":41,"investigatorTitle":42,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Hassan mostafa abdelbaky ahmed","Assistant lecturer","100608287","dexmedetomidine-versus-magnesium-sulfate-infusion-in-craniotomy-100608287",false,"NCT07199595","Dexmedetomidine Versus Magnesium Sulfate Infusion in Craniotomy","Effect of Dexmedetomidine Versus Magnesium Sulfate Infusion on Intracranial Pressure and Cerebral Perfusion Pressure in Craniotomy Using Lumbar Drain Catheter","Inclusion Criteria:\n\n* Age 18-65 years\n* Elective craniotomy for supratentorial pathology\n* No contraindication to lumbar drain insertion\n* Baseline mental status is stable, allowing for a reliable postoperative neurological evaluation can be done\n* ASA physical status I-III\n\nExclusion Criteria:\n\n* Coagulopathy or current anticoagulation\n* Severe renal or hepatic dysfunction\n* Known allergy to study medications\n* traumatic brain injury","ALL","18 Years","65 Years",{"count":54,"type":55},60,"ESTIMATED","INTERVENTIONAL",[58],"NA","To compare the intraoperative effects of Dexmedetomidine and Magnesium Sulfate infusion on intracranial pressure and cerebral perfusion pressure in adult patients undergoing craniotomy",[61],"Craniotomy Surgery","NOT_YET_RECRUITING","2025-09-22",{"date":65,"type":66},"2025-09-30","ACTUAL",{"date":68,"type":55},"2025-10-20",{"date":70,"type":55},"2026-11-01",{"name":5,"class":6}]