[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100551759":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":26,"centralContacts":35,"locations":42,"responsibleParty":62,"collaborators":40,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":40,"eligibilityCriteria":70,"healthyVolunteers":66,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":40,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":40,"overallStatus":45,"whyStopped":40,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Egymedicalpedia","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Dexmedetomidine Group","EXPERIMENTAL","This Group about 30 patients will receive a loading dose of 1 μg\u002Fkg dexmedetomidine (Precedex 4 mcg\u002Fml, Pfizer. Inc, New York, USA) diluted in 100 ml 0.9% saline infused over 10 min immediately postoperative, followed by continuous infusion of 0.2-0.7 μg\u002Fkg\u002Fh.",[13],"Drug: Dexmedetomidine",{"label":15,"type":10,"description":16,"interventionNames":17},"Fentanyl Group","This Group about 30 patients will receive an initial bolus dose of fentanyl (fentanyl 50 mcg\u002Fml, hameln; Netherlands) of 1-2 μg\u002Fkg, followed by an infusion at an initial rate of 1 to 2 μg\u002Fkg\u002Fh.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DRUG","Dexmedetomidine","to investigate the postoperative analgesic-sedative effect of dexmedetomidine versus fentanyl-midazolam to achieve fast-track extubation after adult valvular cardiac surgeries.",[9,15],[25],"fentanyl 50 mcg\u002Fml",[27,31],{"name":28,"affiliation":29,"role":30},"Mohammed Ibrahim Mohammed Hashish, Professor","Al-Azhar University, Faculty of medicine","STUDY_CHAIR",{"name":32,"affiliation":33,"role":34},"Mohamed husseiny Mahmoud, Lecturer","Cardio-Thoracic Surgery Department, Al-Azhar University","PRINCIPAL_INVESTIGATOR",[36],{"name":37,"role":38,"phone":39,"phoneExt":40,"email":41},"Ahmed Ramadan Ibrahim, MSC","CONTACT","+201002749797",null,"782014arar@gmail.com",[43],{"facility":44,"status":45,"city":46,"state":40,"zip":40,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Al-Azhar University hospitals","RECRUITING","Cairo","Egypt","EG",{"type":50,"coordinates":51},"Point",[52,53],31.24967,30.06263,{"lat":53,"lon":52},[56,58,60],{"name":57,"role":38,"phone":39,"phoneExt":40,"email":41},"Ahmed Ramadan Ibrahim, M.D",{"name":59,"role":38,"phone":40,"phoneExt":40,"email":40},"Assist.Prof.",{"name":61,"role":34,"phone":40,"phoneExt":40,"email":40},"Ismail Mohamed Abdelgawad, Assist.Prof.",{"type":63,"investigatorFullName":40,"investigatorTitle":40,"investigatorAffiliation":40,"oldNameTitle":40,"oldOrganization":40},"SPONSOR","100551759","dexmedetomidine-versus-midazolam-fentanyl-for-analgesia-and-sedation-100551759",false,"NCT06464263","Dexmedetomidine Versus Midazolam-Fentanyl for Analgesia and Sedation","Comparative Study Between Dexmedetomidine Versus Midazolam-Fentanyl for Analgesia and Sedation After Adult Valvular Cardiac Surgeries; a Prospective Randomized Blinded Clinical Trial","Inclusion Criteria:\n\n\\- This study will include patients undergoing elective adult valvular cardiac surgeries\n\nExclusion Criteria:\n\n* Patient refusal.\n* Emergent valve cardiac surgeries.\n* Patients with known hypersensitivity to study drugs.\n* History of uncontrolled diabetes or hypertension.\n* Impaired kidney or liver functions.\n* Perioperative hemodynamic instability.","ALL","21 Years","50 Years",{"count":75,"type":76},60,"ESTIMATED","INTERVENTIONAL",[79],"NA","Postoperative sedation is an essential component in recovery of the patient undergoing cardiac surgery. It facilitates the patient's unawareness of the environment as well as reduce the discomfort and anxiety caused by surgery, intubation, mechanical ventilation, suction, and physiotherapy.\n\nDespite the advances in anesthesia and surgical techniques, the duration of mechanical ventilation (MV) may be prolonged after cardiac surgery, due to the classic high-dose narcotic-based cardiac anesthesia.",[82],"Valvular Cardiac Surgeries","2024-06-12",{"date":85,"type":86},"2024-06-18","ACTUAL",{"date":88,"type":86},"2024-02-10",{"date":90,"type":76},"2026-02-10",{"name":5,"class":6},1]