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The patient or guardian agrees to the study protocol and the schedule of clinical follow-up, and provides informed, written consent, as approved by the appropriate Institutional Review Board\u002FEthical Committee of the respective clinical site.\n\nExclusion Criteria:\n\n1. Unprotected left main coronary artery disease.\n2. The presence of complex coronary disease anatomy or lesion characteristics or other cardiac condition(s) which leads the participating interventional cardiologist to believe that PCI is not suitable (i.e. the subject should be managed with CABG or medical therapy alone).\n3. Recent ST-elevation myocardial infarction(\\\u003C5 days prior to randomization).\n4. Cardiogenic shock and\u002For need for mechanical\u002Fpharmacologic hemodynamic support.\n5. Severe left ventricular dysfunction (ejection fraction \\\u003C30%).\n6. Requirement for other cardiac or non-cardiac surgical procedure (e.g., valve replacement, aorta surgery, or carotid revascularization). However, a maze procedure or pulmonary vein isolation is allowed.\n7. Contraindication or inability to take aspirin or P2Y12 inhibitors (clopidogrel, ticagrelor, or prasugrel) for at least 6 months.\n8. Prior CABG.\n9. Extremely calcified or tortuous vessels precluding FFR measurement or intracoronary imaging evaluation.\n10. More than one major epicardial vessel which is chronically occluded; enrollment of 1 Chronic total occlusion lesion is allowed.\n11. Subjects requiring or who may require additional surgery (cardiac or noncardiac) within 1 year.\n12. End-stage renal disease requiring renal replacement therapy.\n13. Liver cirrhosis.\n14. Pregnant and\u002For lactating women.\n15. Concurrent medical condition with a limited life expectancy of less than 2 years.\n16. Patients who are actively participating in another drug or device investigational study, which have not completed the primary endpoint follow-up period. However, where at least one or more conditions are satisfied, it could be an exception according to an investigator's discretion;\n\n1\\) Participated in the observational study expected no effect on the safety and\u002For effectiveness evaluation of this trial.\n\n2\\) Screening failed before any interventional factor is involved.\n\n3\\) Participated in academic trials like strategic comparison studies conducted under standard therapy provided that there is no additional risk or a specific procedure to a subject and no interference between this trial and other studies.","ALL","20 Years",{"count":529,"type":530},1500,"ESTIMATED","INTERVENTIONAL",[533],"NA","The objective of this randomized study was to compare outcomes of imaging-and physiology-guided state-of-the-art percutaneous coronary intervention (PCI) to coronary artery bypass grafting (CABG) in patients with diabetes and three-vessel CAD (not involving left main).",[536],"Coronary Artery Stenosis",[538,539,22,15,540],"Multivessel Coronary Artery Disease","state of the art","Diabetes Mellitus","2026-06-23",{"date":543,"type":544},"2026-06-24","ACTUAL",{"date":546,"type":544},"2024-06-14",{"date":548,"type":530},"2029-12-31",{"name":513,"class":6},39]